Educating law students for rural and regional legal practice: embedding place consciousness in law curricula

As with other professions, the declining rates of recruitment and retention of lawyers in rural and regional Australia is of significant concern. Whilst the causes of this vary between communities, common depictions of the rural and regional lawyer’s role indicate that employment as a lawyer in such areas is characterised by unique personal and professional challenges. Nonetheless, employment as a rural and regional lawyer also offers practitioners rewarding opportunities and lifestyle benefits. Research from other disciplines indicates that the challenges inherent in rural and regional professional practice may be alleviated, and benefits more easily harnessed, via place conscious discipline-specific curriculum that sensitises tertiary students to, and prepares them for, the rural and regional career context.Largely oriented towards substantive content to satisfy external accrediting bodies, undergraduate legal education does not typically acknowledge the ‘places’in which graduates will practice as professionals. This article argues however that there is scope to incorporate place within legal education, and documents an innovative curriculum development project which embeds place consciousness to better prepare law students for employment in rural and regional legal practice.Drawing upon methods from other disciplines, the project team designed a curriculum package which aims to sensitise students to the rural and regional legal practice context, and equip them with the skills to overcome challenges and take advantage of the opportunities available in a rural or regional professional career

Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts

Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori-type RuII catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X-ray crystal structures of the 16-electron OsII catalysts are almost identical to those of RuII. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The OsII catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones

Salt marsh die-off and recovery reveal disparity between the recovery of ecosystem structure and service provision

a b s t r a c t Coastal ecosystems, such as sand dunes, salt marshes, and mangroves, stabilize shorelines and protect coastal populations. In New England, salt marshes have experienced widespread cordgrass (Spartina alterniflora) die-off and habitat loss, and it is unknown how this has affected their ability to provide coastal protection. We quantified wave attenuation and shoreline stability on healthy, die-off and recovered marsh creek banks. We found that coastal protection has been severely compromised by salt marsh die-off, and that to date, S. alterniflora recovery, while superficially impressive, has not returned this ecosystem service to the levels of intact marshes. Climate driven sea-level rise and predicted increases in the frequency and severity of storms over the next century will likely further increase the vulnerability of coastal populations. Therefore, recovery of coastal protection is essential for maintaining the ecological and economic wellbeing of coastal communities. Our results suggest that quantification of the recovery of ecosystem services should be employed in order to successfully measure recovery in degraded ecosystems

Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells

Catalytic anticancer metallodrugs active at low doses could minimise side-effects, introduce novel mechanisms of action which combat resistance, and widen the spectrum of anticancer drug activity. We have used new highly-stable chiral half-sandwich organometallic Os(II) arene sulfonyl diamine complexes, [Os(arene)(TsDPEN)] to achieve highly enantioselective reduction of pyruvate, a key intermediate in metabolic pathways, both in aqueous model systems and in human cancer cells, using non-toxic concentrations of sodium formate as a hydride source. Importantly the catalytic mechanism generates selectivity towards ovarian cancer cells versus non-cancerous fibroblasts (both ovarian and lung), which are commonly used as models of healthy proliferating cells. The formate precursor N-formylmethionine was explored as an alternative to formate in PC3 prostate cancer cells, which are known to over-express a deformylase enzyme. Transfer hydrogenation catalysts generating reductive stress in cancer cells offer a ground-breaking new approach to cancer therapy

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

This work was financially supported by the Leverhulme Trust (RPG-2017-214) and BBSRC (BB/J006467/1 and BB/V014684/1). We thank Prof. Andrew Riches (University of St. Andrews) for provision of materials, and Dr. Elizabeth Bolitho (University of Warwick) for assistance with cell culture experiments.The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.Publisher PDFPeer reviewe

New Approaches to Clover Breeding

White clover (Trifolium repens L.) and red clover (T. pratense) are the major forage legumes of temperate pastures. Breeding efforts have focused on overcoming the constraints to productivity and reliability in this species and thereby optimising their contribution to mixed swards. In recent years there has been an increased emphasis on livestock production and the efficient utilisation of forage material in the rumen. In this paper we report on a shift in the aims of forage legume breeding at IGER, building on a strong agronomic platform but giving greater consideration to the environmental footprint of our varieties and the contribution that they can make to the quality of meat and milk