INFLUENCE OF PREPARATION PROCESS ON PHYSICAL PROPERTIES AND DEVITRIFICATION OF Li2B2O4 (0,9) LiFe5O8 (0,1) GLASSES

Double roller quenching of Li2B2O4(0.9)-LiFe5O8(0.1) has been performed with various melt temperatures and roller speeds. The changes in physical properties or in the devitrification process of the amorphous samples are shown to be related to the LiFe5O8 content variations or to the Fe2+ appearance but not to structural changes of the amorphous state due to preparation processe

Platelet signalling networks: pathways perturbation demonstrates differential sensitivity of ADP secretion and fibinogen binding.

Platelet signalling responses to single agonists have been identified previously. However a model of the total platelet signalling network is still lacking. In order to gain insights into this network, we explored the effects of a range of platelet-function inhibitors in two independent assays of platelet function, namely fibrinogen binding and ADP secretion. In this study, we targeted the intracellular signalling molecules Syk and PI3K, the prostaglandin synthesis enzyme COX, surface receptors for TxA2 and ADP (P2Y1 and P2Y12) and the integrin cell adhesion molecule, aIIbb3. We demonstrate that the platelet responses of fibrinogen binding and secretion can be differentially affected by the individual inhibitors permitting the generation of a model delineating novel regulatory links in the platelet signal network. Importantly, the model illustrates the interconnections among portions that are traditionally studied as separate modules, promoting a more integrated view of the platelet

Ordering intermetallic alloys by ion irradiation: a way to tailor magnetic media

Combining He ion irradiation and thermal mobility below 600K, we both trigger and control the transformation from chemical disorder to order in thin films of an intermetallic ferromagnet (FePd). Kinetic Monte Carlo simulations show how the initial directional short range order determines order propagation. Magnetic ordering perpendicular to the film plane was achieved, promoting the initially weak magnetic anisotropy to the highest values known for FePd films. This post-growth treatment should find applications in ultrahigh density magnetic recording.Comment: 7 pages, 3 Figure

Alpes et Pyrénées : descriptions et curiosités de la Suisse, de la Savoie, de la Navarre, du Béarn, du Bigorre et du Comminges,...

En la port.:"Ascensions de Montagnes, pics et glaciers, traversées de mers de glace,oules, cols et ports, visites de lacs,cascades et vallées, excursions aux ruines, courses a pied,a cheval, en steamers, en poste, en voiturins

Titanium oxo-clusters derivatized from the Ti10O12(cat)8(py)8 complex: structural investigation and spectroscopic studies of light absorption

A series of deep-red colored nano-sized titanium oxo-clusters bearing catecholato ligands is reported. These architectures are produced via post-synthetic modification of the Ti10O12(cat)8(py)8 (cat = catecholato, py = pyridine) complex through quantitative substitution of labile pyridine ligands by three substituted pyridines (pico, 4-Phpy and pyrald). The crystal structure analysis reveals a common Ti10O12(cat)8 backbone for the three isolated molecular architectures. Partial charge analysis indicates two types of titanium atoms within these complexes with one resembling titanium(IV) found in TiO2. These complexes strongly absorb visible light in solution (λmax = 411 nm, ε = 10 800 for Ti10O12(cat)8(py)8 in CHCl3) and in the solid-state. The band gaps estimated from the reflectance spectra are between 1.85 eV and 1.97 eV. The present work also details the HOMO and LUMO representations obtained via DFT calculation for Ti10O12(cat)8(py)8 and a virtual Ti10O12(cat)8 complex as well as the DOS (density of states) plots calculated for those structures. This computational study highlights an impact of the pyridine ligand on the DOS plots

On h h -transforms of one-dimensional diffusions stopped upon hitting zero

For a one-dimensional diffusion on an interval for which 0 is the regular-reflecting left boundary, three kinds of conditionings to avoid zero are studied. The limit processes are $h$-transforms of the process stopped upon hitting zero, where $h$'s are the ground state, the scale function, and the renormalized zero-resolvent. Several properties of the $h$-transforms are investigated

Scaled penalization of Brownian motion with drift and the Brownian ascent

We study a scaled version of a two-parameter Brownian penalization model introduced by Roynette-Vallois-Yor in arXiv:math/0511102. The original model penalizes Brownian motion with drift $h\in\mathbb{R}$ by the weight process ${\big(\exp(\nu S_t):t\geq 0\big)}$ where $\nu\in\mathbb{R}$ and $\big(S_t:t\geq 0\big)$ is the running maximum of the Brownian motion. It was shown there that the resulting penalized process exhibits three distinct phases corresponding to different regions of the $(\nu,h)$-plane. In this paper, we investigate the effect of penalizing the Brownian motion concurrently with scaling and identify the limit process. This extends a result of Roynette-Yor for the ${\nu<0,~h=0}$ case to the whole parameter plane and reveals two additional "critical" phases occurring at the boundaries between the parameter regions. One of these novel phases is Brownian motion conditioned to end at its maximum, a process we call the Brownian ascent. We then relate the Brownian ascent to some well-known Brownian path fragments and to a random scaling transformation of Brownian motion recently studied by Rosenbaum-Yor.Comment: 32 pages; made additions to Section

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and accordingly treatment with GABA-A antagonists can efficiently restore cognitive functions of Ts65Dn mice, a genetic model for DS. However, GABA-A antagonists are also convulsant which preclude their use for therapeutic intervention in DS individuals. Here, we have evaluated safer strategies to release GABAergic inhibition using a GABA-A-benzodiazepine receptor inverse agonist selective for the α5-subtype (α5IA). We demonstrate that α5IA restores learning and memory functions of Ts65Dn mice in the novel-object recognition and in the Morris water maze tasks. Furthermore, we show that following behavioural stimulation, α5IA enhances learning-evoked immediate early gene products in specific brain regions involved in cognition. Importantly, acute and chronic treatments with α5IA do not induce any convulsant or anxiogenic effects that are associated with GABA-A antagonists or non-selective inverse agonists of the GABA-A-benzodiazepine receptors. Finally, chronic treatment with α5IA did not induce histological alterations in the brain, liver and kidney of mice. Our results suggest that non-convulsant α5-selective GABA-A inverse agonists could improve learning and memory deficits in DS individuals

Aquaporin gene expression and apoplastic water flow in bur oak (Quercus macrocarpa) leaves in relation to the light response of leaf hydraulic conductance

It has previously been shown that hydraulic conductance in bur oak leaves (Quercus macrocarpa Michx.), measured with the high pressure flow meter technique (HPFM), can significantly increase within 30 min following exposure to high irradiance. The present study investigated whether this increase could be explained by an increase in the cell-to-cell pathway and whether the response is linked to changes in the transcript level corresponding to aquaporin genes. Four cDNA sequences showing high similarity to members of the aquaporin gene family from other plant species were characterized from bur oak leaves and the expression levels of these cDNA sequences were examined in leaves by quantitative real-time PCR (QRT-PCR). No change was found in the relative transcript abundance corresponding to these four putative aquaporin genes in leaves with light-induced high hydraulic conductance (exposed to high irradiance) compared to leaves with low hydraulic conductance (exposed to low irradiance). However, in sun leaves that were exposed to different light levels prior to leaf collection (full sunlight, shade, and covered with aluminium foil for 16 h), the relative transcript levels of two of the putative aquaporin genes increased several-fold in shaded leaves compared to the sun-exposed or covered leaves. When the leaves were pressure-infiltrated with the apoplastic tracer dye trisodium 3-hydroxy-5,8,10-pyrenetrisulphonate (PTS3, 0.02%), there was no change in the PTS3 concentration of leaf exudates collected in ambient light or in high irradiance, but there was a small apoplastic acidification. There was also no change in PTS3 concentration between the leaves infiltrated under high irradiance with 0.02% PTS3 or with 0.1 mM HgCl2 in 0.02% PTS3. The results suggest that the putative aquaporin genes that were identified in the present study probably do not play a role in the light responses of hydraulic conductance at the transcript level, but they may function in regulating water homeostasis in leaves adapted to different light conditions. In addition, it is shown that high irradiance induced changes in the pH of the apoplast and that there does not appear to be a significant shift to the cell-to-cell mediated water transport in bur oak leaves exposed to high irradiance as measured by the apoplastic tracer dye

Localisation de réseau de drainage agricole par tomographie de résistivité électrique en mode de suivi temporel

9ème colloque GEOFCAN, Orsay, FRA, 13-/11/2014 - 14/11/2014International audienceLa pose d'un réseau de drain dans un sol agricole permet la maîtrise du risque d'engorgement des terres en eau lors de période de pluies importantes. Cependant le positionnement de ce réseau est très souvent perdu. Dans le but de réaliser un protocole permettant la localisation de drain agricole à faible diamètre, des profils de tomographie de résistivité électrique (ERT) 3D en mode de suivi temporel ont été réalisés. Associés à une expérimentation d'injection d'eau par l'aval d'un réseau de drains ils ont permis de suivre la réhumectation et l'infiltration provoquées par cette injection. La modélisation au cours du temps de ces zones d'infiltration a permis la localisation et l'évaluation du système de drain