The Difference in Physical Health Between High-Income and Low-Income Populations in Tennessee

Good overall physical health can be a protective factor against cognitive decline in aging. A good diet, routine exercise, and mindfulness to personal mental health are three main aspects that help determine one’s overall well-being. Socioeconomic status may play a factor in the ability to have access to resources for all three aspects of overall health previously stated. This data is important because it may impact how future researchers go about finding ways to help underprivileged communities. This study aimed to report significant factors that contribute to physical health in relation to cognitive aging from studying six different counties throughout the state of Tennessee. We obtained this data from mySidewalk which is a platform that helps organize and share data to the general public. This study consisted of residents of the highest and lowest average income counties. The low-income counties consisted of Jackson County, Clay County, and Hancock County while the high-income counties consisted of Williamson County, Davidson County, and Wilson County. We measured three variables in this study which consisted of seniors one-mile urban or ten-miles rural with low access to healthy food in ages 65 and older, poor mental health, and no leisure-time physical activity among adults. We hypothesized people with poor physical health in relation to aging tend to face issues with cognitive functioning and found that our hypothesis was supported. Poor mental health was the only variable that did not show significant difference between the high- and low-income counties. Our analysis revealed that lower income populations may lack in fields including but limited not limited to transportation, lack of stores in the area, and lack of adequate time to go grocery shopping. This contributes to why there is a disparity in cognitive decline in relation to aging between high- and low-income populations in Tennessee

A Current Mode Detector Array for Gamma-Ray Asymmetry Measurements

We have built a CsI(Tl) gamma-ray detector array for the NPDGamma experiment to search for a small parity-violating directional asymmetry in the angular distribution of 2.2 MeV gamma-rays from the capture of polarized cold neutrons by protons with a sensitivity of several ppb. The weak pion-nucleon coupling constant can be determined from this asymmetry. The small size of the asymmetry requires a high cold neutron flux, control of systematic errors at the ppb level, and the use of current mode gamma-ray detection with vacuum photo diodes and low-noise solid-state preamplifiers. The average detector photoelectron yield was determined to be 1300 photoelectrons per MeV. The RMS width seen in the measurement is therefore dominated by the fluctuations in the number of gamma rays absorbed in the detector (counting statistics) rather than the intrinsic detector noise. The detectors were tested for noise performance, sensitivity to magnetic fields, pedestal stability and cosmic background. False asymmetries due to gain changes and electronic pickup in the detector system were measured to be consistent with zero to an accuracy of $10^{-9}$ in a few hours. We report on the design, operating criteria, and the results of measurements performed to test the detector array.Comment: 33 pages, 20 figures, 2 table

Reaching across continents : engaging students through virtual collaborations

Business schools have the responsibility of preparing students for work in multicultural organizations and global markets. This paper examines a situated learning experience for undergraduates through a virtual collaboration between a UK university and a Brazilian university. This facilitated remote communication using social media and smart devices, allowing students from both institutions to enhance their cross-cultural management competencies. A qualitative approach was used for the research, drawing on the reflections of the tutors from both institutions, and feedback received from students in the UK and Brazil. This paper provides empirical observations regarding the use of this innovative pedagogic approach, generating discussion of the implications for teaching, thus contributing to the literature on international collaborations in cross-cultural management education

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anticancer therapy are under way. Here, we performed a genome-wide haploid genetic screen to identify resistance mechanisms to 3-bromopyruvate (3-BrPA), a drug candidate that inhibits glycolysis in a poorly understood fashion. We identified the SLC16A1 gene product, MCT1, as the main determinant of 3-BrPA sensitivity. MCT1 is necessary and sufficient for 3-BrPA uptake by cancer cells. Additionally, SLC16A1 mRNA levels are the best predictor of 3-BrPA sensitivity and are most elevated in glycolytic cancer cells. Furthermore, forced MCT1 expression in 3-BrPA–resistant cancer cells sensitizes tumor xenografts to 3-BrPA treatment in vivo. Our results identify a potential biomarker for 3-BrPA sensitivity and provide proof of concept that the selectivity of cancer-expressed transporters can be exploited for delivering toxic molecules to tumors.National Institutes of Health (U.S.) (NIH CA103866)Jane Coffin Childs Memorial Fund for Medical Research (Fellowship)National Science Foundation (U.S.) (Fellowship)Howard Hughes Medical Institute (Investigator

Measurement of the Parity Violating Asymmetry A

The weak pion-nucleon coupling constant H{sub {pi}}{sup 1} remains poorly determined, despite many years of effort. The recent measurement of the {sup 133}Cs anapole moment has been interpreted to give a value of H{sub {pi}}{sup 1} almost an order of magnitude larger than the limit established in the {sup 18}F parity doublet experiments. A measurement of the gamma ray directional asymmetry A{sub {gamma}} for the capture of polarized neutrons by hydrogen has been proposed at Los Alamos National Laboratory. This experiment will determine H{sub {pi}}{sup 1} independent of nuclear structure effects. However, since the predicted asymmetry is small, A{sub {gamma}} {approximately} 5 x 10{sup {minus}8}, systematic effects must be reduced to < 5 x 10{sup {minus}9}. The design of the experiment will is presented, with an emphasis on the techniques used for controlling systematic errors

Análisis de co-palabras aplicado a los artículos muy citados en Biblioteconomía y Ciencias de la Información (2007-2017)

Se identifican las relaciones entre los conceptos y las áreas temáticas principales dentro de la categoría Biblioteconomía y Ciencias de la Información de Web of Science, en el periodo 2007-2017, utilizando la herramienta analítica “Essential Science Indicators”. Partiendo de los artículos altamente citados, la metodología consistió en la aplicación de análisis de co-palabras así como técnicas estadísticas de análisis multivariante y visualización a través de un mapa de la ciencia. Los resultados principales mostraron que las áreas de mayor interés para los investigadores fueron los estudios sobre la Web 2.0 basados en la participación colaborativa de los usuarios, la evaluación de las actividades científica, las métricas alternativas, o Altmetrics, desarrolladas en las plataformas sociales y académicas, la seguridad y confianza en los entornos virtuales y, por último, la aplicación de plataformas digitales en el comercio electrónicoThis paper aims to identify the conceptual structure in the category Library and Information Sciences in the Web of Science, in the period 2007-2017, using the analytical tool Essential Science Indicators. Based on highly cited papers, the methodology consisted in the application of co-word analysis and multivariate analysis techniques and visualization through science mapping. The main results showed that the studies on Web 2.0 based on the collaborative participation of the users, the evaluation of scientific activities, as well as the alternative metrics developed in the social and academic platforms, such as Altmetrics, trust in virtual environments, and the application of information technologies in companies and digital e-commerce platforms were the areas of greatest interest to the researchers

Hygienemanagement in Pferdebetrieben – Literaturübersicht

Vor dem Hintergrund der aktuellen Seuchenausbrüche bei Tieren und Menschen in ganz Europa sind Tierhalter nicht nur im Nutztierbereich, sondern auch im Pferdesektor bezüglich des Hygienemanagements zunehmend sensibilisiert und kritisch. Die Bestrebungen, mit einem entsprechenden Hygienemanagement, dem Einschleppen von Infektionskrankheiten in den Bestand entgegenzutreten und im konkreten Fall eines Ausbruchs, die Verbreitung mit geeigneten Maßnahmen bestmöglich zu verhindern, scheinen vorhanden zu sein. In der vorliegenden Arbeit sollte die gegenwärtige Praxis bezüglich des Hygienemanagements in Pferdebetrieben anhand der Empfehlungen aus der aktuellen Literatur beschrieben und kritisch diskutiert werden. Dabei spielen neben der allgemeinen Reinigung und Desinfektion von Stallungen/Boxen/Weiden und Equipment auch die Schädlingsbekämpfung sowie die Regelungen bezüglich des Kontaktes zu stallfremden Pferden (Quarantänemaßnahmen), anderen Tieren (Hunde, Katzen) sowie Entwurmungs- und Impfregime eine wichtige Rolle. Trotz zahlreicher Empfehlungen ist es unwahrscheinlich, dass Pferdebetriebe dies tatsächlich in allen relevanten Belangen auch zielführend in die Realität umsetzen. Hier scheint in vielen Bereichen eine Verbesserung/Optimierung empfehlenswert. Auch das Einführen von einheitlichen Empfehlungen/Leitlinien für das Hygienemanagement in Pferdebetrieben erscheint sinnvoll

Reliability of the VmaxST portable metabolic measurement system

The purpose of this study was to evaluate the reliability of the VmaxST portable metabolic measurement system. Forty-five healthy adults (age = 25.7 ± 5.9 yr; height = 171.8 ± 9.1 cm; weight = 69.6 ± 12.8 kg; VO(2)peak = 40.7 ml/kg/min; percent fat = 21.7 ± 11.0) performed two separate and identical exercise routines on different days consisting of treadmill walking at 2.0 mph (53.6 m/min), 3.0 mph (80.5 m/min), and 4.0 mph (107.3 m/min) and running at 6.0 mph (160.9 m/min). V(E) and gas exchange were measured continuously breath-to-breath. A random effects model on log-transformed data yielded coefficients of variation (CV) and intraclass correlation coefficients (ICC) for VO(2) and V(E) of 5.2–7.6%, and 0.77–0.92, respectively, for all walking and running trials. For VCO(2), CVs were higher (10–12%) and ICCs lower (0.70–0.81). Ordinary least squares regression between the individual difference scores and the individual mean scores for V(E), VO(2) and VCO(2), respectively, indicated no systematic bias (all p > 0.05). Bland-Altman analysis also illustrated no systematic bias between repeated measurements. The VmaxST provides reliable measurements of VO(2) and V(E) duringduring walking and running eliciting V(E) and VO(2) at least up to ~56 and 2.2 l/min, respectively. The system appears to be less reliable for measuring VCO(2)