158 research outputs found
Euler hydrodynamics of one-dimensional attractive particle systems
We consider attractive irreducible conservative particle systems on
, without necessarily nearest-neighbor jumps or explicit invariant
measures. We prove that for such systems, the hydrodynamic limit under Euler
time scaling exists and is given by the entropy solution to some scalar
conservation law with Lipschitz-continuous flux. Our approach is a
generalization of Bahadoran et al. [Stochastic Process. Appl. 99 (2002) 1--30],
from which we relax the assumption that the process has explicit invariant
measures.Comment: Published at http://dx.doi.org/10.1214/009117906000000115 in the
Annals of Probability (http://www.imstat.org/aop/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Supercriticality conditions for asymmetric zero-range process with sitewise disorder
We discuss necessary and sufficient conditions for the convergence of
disordered asymmetric zero-range process to the critical invariant measures.Comment: 28 pages. arXiv admin note: text overlap with arXiv:1411.430
Lagrangian phase transitions in nonequilibrium thermodynamic systems
In previous papers we have introduced a natural nonequilibrium free energy by
considering the functional describing the large fluctuations of stationary
nonequilibrium states. While in equilibrium this functional is always convex,
in nonequilibrium this is not necessarily the case. We show that in
nonequilibrium a new type of singularities can appear that are interpreted as
phase transitions. In particular, this phenomenon occurs for the
one-dimensional boundary driven weakly asymmetric exclusion process when the
drift due to the external field is opposite to the one due to the external
reservoirs, and strong enough.Comment: 10 pages, 2 figure
Entropy of non-equilibrium stationary measures of boundary driven TASEP
Prova tipográficaWe examine the entropy of non-equilibrium stationary states of boundary driven totally asymmetric simple exclusion processes. As a consequence, we obtain that the Gibbs-Shannon entropy of the non equilibrium stationary state converges to the Gibbs-Shannon entropy of the local equilibrium state. Moreover, we prove that its fluctuations are Gaussian, except when the mean displacement of particles produced by the bulk dynamics agrees with the particle flux induced by the density reservoirs in the maximal phase regime.FCT, Égid
Why spontaneous symmetry breaking disappears in a bridge system with PDE-friendly boundaries
We consider a driven diffusive system with two types of particles, A and B,
coupled at the ends to reservoirs with fixed particle densities. To define
stochastic dynamics that correspond to boundary reservoirs we introduce
projection measures. The stationary state is shown to be approached dynamically
through an infinite reflection of shocks from the boundaries. We argue that
spontaneous symmetry breaking observed in similar systems is due to placing
effective impurities at the boundaries and therefore does not occur in our
system. Monte-Carlo simulations confirm our results.Comment: 24 pages, 7 figure
Conditioned stochastic particle systems and integrable quantum spin systems
We consider from a microscopic perspective large deviation properties of
several stochastic interacting particle systems, using their mapping to
integrable quantum spin systems. A brief review of recent work is given and
several new results are presented: (i) For the general disordered symmectric
exclusion process (SEP) on some finite lattice conditioned on no jumps into
some absorbing sublattice and with initial Bernoulli product measure with
density we prove that the probability of no absorption event
up to microscopic time can be expressed in terms of the generating function
for the particle number of a SEP with particle injection and empty initial
lattice. Specifically, for the symmetric simple exclusion process on conditioned on no jumps into the origin we obtain the explicit first and
second order expansion in of and also to first order in
the optimal microscopic density profile under this conditioning. For the
disordered ASEP on the finite torus conditioned on a very large current we show
that the effective dynamics that optimally realizes this rare event does not
depend on the disorder, except for the time scale. For annihilating and
coalescing random walkers we obtain the generating function of the number of
annihilated particles up to time , which turns out to exhibit some universal
features.Comment: 25 page
SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells
SIRT1 operates as both a tumor suppressor and oncogenic factor depending on the cell context. Whether SIRT1 plays a role in melanoma biology remained poorly elucidated. Here, we demonstrate that SIRT1 is a critical regulator of melanoma cell proliferation. SIRT1 suppression by genetic or pharmacological approaches induces cell cycle arrest and a senescence-like phenotype. Gain and loss of function experiments show that M-MITF regulates SIRT1 expression, thereby revealing a melanocyte-specific control of SIRT1. SIRT1 over-expression relieves the senescence-like phenotype and the proliferation arrest caused by MITF suppression, demonstrating that SIRT1 is an effector of MITF-induced proliferation in melanoma cells. Interestingly, SIRT1 level and activity are enhanced in the PLX4032-resistant BRAF(V600E)-mutated melanoma cells compared with their sensitive counterpart. SIRT1 inhibition decreases melanoma cell growth and rescues the sensibility to PLX4032 of PLX4032-resistant BRAF(V600E)-mutated melanoma cells. In conclusion, we provide the first evidence that inhibition of SIRT1 warrants consideration as an anti-melanoma therapeutic option
Evaluation of the glycemic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome. a pilot study
Methotrexate (MTX) is a systemic immunosuppressant drug used for the treatment of psoriasis and psoriatic arthritis. Previous studies demonstrated a potential association between psoriasis and diabetes mellitus, obesity, atherosclerosis, hypertension, eventuating into metabolic syndrome. This study aimed at exploring the glycemic effects of MTX in psoriatic arthritis (PsA) patients. In this prospective cross-sectional study, 27 patients with PsA were evaluated. The status of PsA and presence of accompanying metabolic syndrome was determined by standard criteria and indices. Blood indicators including HbA1c, erythrocyte sedimentation rate, fasting blood sugar, total cholesterol, high-density lipoprotein, triglycerides, and C-reactive protein were examined before and 12 weeks after MTX therapy. There were no significant changes between HbA1c levels before and after MTX therapy in both genders (men: P=0.131, women: P=0.803). In addition, HbA1c levels in PsA patients with metabolic syndrome were not different before and after treatment (P=0.250). Finally, HbA1c levels did not change in PsA patients without metabolic syndrome before and after therapy (P=0.506). MTX in PsA patients does not appear to have hyperglycaemic effects in the short-term and can be safely used in patients with metabolic syndrome and diabete
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