Accommodating Maternal Age in CRIB Scale: Quantifying the Effect on the Classification

Receiver operating characteristic (ROC) curves are a well-accepted measure of accuracy of diagnostic tests using in continuous or ordinal markers. Based on the notion of using a threshold to classify subjects as positive (diseased) or negative (no diseased), a ROC curve is a plot of the true positive fraction (TPF) versus the false positive fraction (FPF) for all possible cut points. Thus, it describes the whole range of possible operating characteristic for the test and hence its inherent capacity for distinguish between two status. The clinical severity scale CRIB - Clinical Risk Index for Babies, emerged in 1993 to predict the mortality of newborn at less than 32 weeks of gestation and very low birth weight (< 1500gr) [4]. In previous work of Braga [3] this index was reported as showing a good performance in assessing risk of death for babies with very low birth weight (less than 1500 g weight). However, in some situations, the performance of the diagnostic test, the ROC curve itself and the Area Under the Curve(AUC) can be strongly influenced by the presence of covariates, whether continuous or categorical [5], [32], [33]. The World Health Organization and the Ministry of Health, defined as "late pregnancy" that thus occurs in women over 35 years. In this work, using the conditional ROC curve, we analyze the effect of one covariate, maternal age, on the ROC curve that representing the diagnostic test performance. We chose two age status, less than 35 years old and equal or greater than 35 years old, to verify the effects on the discriminating power of CRIB scale, in the process classification using R and STATA software.info:eu-repo/semantics/publishedVersio

Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling

The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin rhodocytin is abolished in the absence of the tyrosine kinase Syk but is not altered in the absence of the major platelet Src family kinases, Fyn, Lyn, and Src, or the tyrosine phosphatase CD148, which regulates the basal activity of Src family kinases. Further, phosphorylation of CLEC-2 by rhodocytin is not altered in the presence of the Src family kinase inhibitor PP2, even though PLCγ2 phosphorylation and platelet activation are abolished. A similar dependence of phosphorylation of CLEC-2 on Syk is also seen in response to stimulation by an IgG mAb to CLEC-2, although interestingly CLEC-2 phosphorylation is also reduced in the absence of Lyn. These results provide the first definitive evidence that Syk mediates phosphorylation of the CLEC-2 hemITAM receptor with Src family kinases playing a critical role further downstream through the regulation of Syk and other effector proteins, providing a new paradigm in signaling by YXXL-containing receptors

BR-262 no Pantanal: cenário de encontros entre homens e animais silvestres.

A BR-262 no seu trecho entre Aquidauana/Anastácio e Corumbá/Ladário em Mato Grosso do Sul é bastante peculiar, pois percorre áreas de Planalto da Bacia do Alto Paraguai e áreas da Planície de inundação do Pantanal. Nessas últimas áreas, onde ocorre uma fauna diversificada em espécies e abundante em número de indivíduos, a pista de rodagem foi construída em condições especiais sobre um aterro para fugir das inundações durante o período de cheia e com muitas pontes para dar passagem para a água. Atualmente, o fluxo nessa estrada vem aumentando devido à maior comercialização entre Brasil, Bolívia e outros países andinos, transformando-se no ?Corredor Bioceânico?. Concomitantemente, estão ocorrendo obras e benfeitorias na estrada e há uma tendência de aumento no índice de atropelamento de animais silvestres. Neste documento, encontra-se a opinião dos autores que fazem uma reflexão a cerca dos fatores envolvidos nos atropelamentos e apontam alternativas e medidas de mitigação para reduzi-los, propondo uma nova forma de abordar esse tema, isto é, assumir a BR-262 no Pantanal como uma área de uso comum para os homens e os animais. A partir desse ponto de vista, justifica-se usufruí-la, não somente como uma via de transporte e comunicação, mas também como um dos mais privilegiados sítios de observação de aves e animais silvestres do País.bitstream/item/80996/1/DOC111.pd

Manejo das forrageiras dos gêneros Brachiaria e Panicum consorciadas com o milho em sistemas de Integração Lavoura-Pecuária.

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Polymorphic microsatellite loci from the endangered Giant Otter (Pteronura brasiliensis).

We describe the first microsatellite loci isolated from the giant otter (Pteronura brasiliensis), an endangered mustelid endemic to South America. Fourteen di- and trinucleotide polymorphic loci were characterised in fourteen individuals from the Pantanal wetlands, Central Brazil. Number of alleles per locus ranged from 2 to 5, and average observed heterozygosity was 0.577. Two loci were in linkage disequilibrium, and one further locus deviated from Hardy?Weinberg equilibrium, probably due to the presence of null alleles. The transferability of these markers to two other mustelids (Lontra longicaudis and Eira barbara) and to the mephitid Conepatus semistriatus was also evaluated. These loci are useful to study the ecology and evolution of these species

On the observability of the neutrino charge radius

It is shown that the probe-independent charge radius of the neutrino is a physical observable; as such, it may be extracted from experiment, at least in principle. This is accomplished by expressing a set of experimental neutrino-electron cross-sections in terms of the finite charge radius and two additional gauge- and renormalization-group-invariant quantities, corresponding to the electroweak effective charge and mixing angle.Comment: 10 pages, 1 figure; a typo in Eq.1 corrected, some comments adde