3,669 research outputs found
Smoking and intention to quit in deprived areas of Glasgow: is it related to housing improvements and neighbourhood regeneration because of improved mental health?
Background: People living in areas of multiple deprivation are more likely to smoke and less likely to quit smoking. This study examines the effect on smoking and intention to quit smoking for those who have experienced housing improvements (HI) in deprived areas of Glasgow, UK, and investigates whether such effects can be explained by improved mental health.
Methods: Quasi-experimental, 2-year longitudinal study, comparing residents’ smoking and intention to quit smoking for HI group (n=545) with non-HI group (n=517), adjusting for baseline (2006) sociodemographic factors and smoking status. SF-12 mental health scores were used to assess mental health, along with self-reported experience of, and General Practitioner (GP) consultations for, anxiety and depression in the last 12 months.
Results: There was no relationship between smoking and HI, adjusting for baseline rates (OR=0.97, 95% CI 0.57 to 1.67, p=0.918). We found an association between intention to quit and HI, which remained significant after adjusting for sociodemographics and previous intention to quit (OR 2.16, 95% CI 1.12 to 4.16, p=0.022). We found no consistent evidence that this association was attenuated by improvement in our three mental health measures.
Conclusions: Providing residents in disadvantaged areas with better housing may prompt them to consider quitting smoking. However, few people actually quit, indicating that residential improvements or changes to the physical environment may not be sufficient drivers of personal behavioural change. It would make sense to link health services to housing regeneration projects to support changes in health behaviours at a time when environmental change appears to make behavioural change more likely
Distribution of contaminants in the environment and wildlife habitat use: a case study with lead and waterfowl on the Upper Texas Coast
The magnitude and distribution of lead contamination remain unknown in wetland systems. Anthropogenic deposition of lead may be contributing to negative population-level effects in waterfowl and other organisms that depend on dynamic wetland habitats, particularly if they are unable to detect and differentiate levels of environmental contamination by lead. Detection of lead and behavioral response to elevated lead levels by waterfowl is poorly understood, but necessary to characterize the risk of lead-contaminated habitats. We measured the relationship between lead contamination of wetland soils and habitat use by mottled ducks (Anas fulvigula) on the Upper Texas Coast, USA. Mottled ducks have historically experienced disproportionate negative effects from lead exposure, and exhibit a unique nonmigratory life history that increases risk of exposure when inhabiting contaminated areas. We used spatial interpolation to estimate lead in wetland soils of the Texas Chenier Plain National Wildlife Refuge Complex. Soil lead levels varied across the refuge complex (0.01–1085.51 ppm), but greater lead concentrations frequently corresponded to areas with high densities of transmittered mottled ducks. We used soil lead concentration data and MaxENT species distribution models to quantify relationships among various habitat factors and locations of mottled ducks. Use of habitats with greater lead concentration increased during years of a major disturbance. Because mottled ducks use habitats with high concentrations of lead during periods of stress, have greater risk of exposure following major disturbance to the coastal marsh system, and no innate mechanism for avoiding the threat of lead exposure, we suggest the potential presence of an ecological trap of quality habitat that warrants further quantification at a population scale for mottled ducks
Differential Privacy and the Fat-Shattering Dimension of Linear Queries
In this paper, we consider the task of answering linear queries under the
constraint of differential privacy. This is a general and well-studied class of
queries that captures other commonly studied classes, including predicate
queries and histogram queries. We show that the accuracy to which a set of
linear queries can be answered is closely related to its fat-shattering
dimension, a property that characterizes the learnability of real-valued
functions in the agnostic-learning setting.Comment: Appears in APPROX 201
Order-Revealing Encryption and the Hardness of Private Learning
An order-revealing encryption scheme gives a public procedure by which two
ciphertexts can be compared to reveal the ordering of their underlying
plaintexts. We show how to use order-revealing encryption to separate
computationally efficient PAC learning from efficient -differentially private PAC learning. That is, we construct a concept
class that is efficiently PAC learnable, but for which every efficient learner
fails to be differentially private. This answers a question of Kasiviswanathan
et al. (FOCS '08, SIAM J. Comput. '11).
To prove our result, we give a generic transformation from an order-revealing
encryption scheme into one with strongly correct comparison, which enables the
consistent comparison of ciphertexts that are not obtained as the valid
encryption of any message. We believe this construction may be of independent
interest.Comment: 28 page
The association between long-term conditions and uptake of population-based screening for colorectal cancer: results from two English cohort studies
Introduction: Uptake of screening for colorectal cancer (CRC) can reduce mortality, and population-based screening is offered in England. To date, there is little evidence on the association between having a long-term condition (LTC) and CRC screening uptake. The objective of this study was to examine the association between having an LTC and uptake of CRC screening in England with the guaiac fecal occult blood test, with a particular focus on common mental disorders. Methods: The study was a preregistered secondary analysis of two cohorts: first, a linked data set between the regional Yorkshire Health Study (YHS) and the National Health Service National Bowel Cancer Screening Program (BCSP, years 2006–2014); second, the national English Longitudinal Study of Ageing (ELSA, years 2014–2015). Individuals eligible for BCSP screening who participated in either the YHS (7,142) or ELSA Wave 7 (4,099) were included. Study registration: ClinicalTrials.gov, number NCT02503969. Results: In both the cohorts, diabetes was associated with lower uptake (YHS odds ratio [OR] for non-uptake 1.35, 95% CI 1.03–1.78; ELSA 1.33, 1.03–1.72) and osteoarthritis was associated with increased uptake (YHS 0.75, 0.57–0.99; ELSA 0.76, 0.62–0.93). After controlling for broader determinants of health, there was no evidence of significantly different uptake for individuals with common mental disorders. Conclusion: Two large independent cohorts provided evidence that uptake of CRC screening is lower among individuals with diabetes and higher among individuals with osteoarthritis. Further work should compare barriers and facilitators to screening among individuals with either of these conditions. This study also demonstrates the benefits of data linkage for improving clinical decision-making
Living IoT: A Flying Wireless Platform on Live Insects
Sensor networks with devices capable of moving could enable applications
ranging from precision irrigation to environmental sensing. Using mechanical
drones to move sensors, however, severely limits operation time since flight
time is limited by the energy density of current battery technology. We explore
an alternative, biology-based solution: integrate sensing, computing and
communication functionalities onto live flying insects to create a mobile IoT
platform.
Such an approach takes advantage of these tiny, highly efficient biological
insects which are ubiquitous in many outdoor ecosystems, to essentially provide
mobility for free. Doing so however requires addressing key technical
challenges of power, size, weight and self-localization in order for the
insects to perform location-dependent sensing operations as they carry our IoT
payload through the environment. We develop and deploy our platform on
bumblebees which includes backscatter communication, low-power
self-localization hardware, sensors, and a power source. We show that our
platform is capable of sensing, backscattering data at 1 kbps when the insects
are back at the hive, and localizing itself up to distances of 80 m from the
access points, all within a total weight budget of 102 mg.Comment: Co-primary authors: Vikram Iyer, Rajalakshmi Nandakumar, Anran Wang,
In Proceedings of Mobicom. ACM, New York, NY, USA, 15 pages, 201
Astrophysical Neutrino Telescopes
This review describes telescopes designed to study neutrinos from
astrophysical sources. These sources include the Sun and Supernovae emitting
neutrino energies up to tens of MeV, atmospheric neutrino sources caused by
cosmic ray interactions and other sources generating neutrino energies ranging
up to eV. Measurements with these telescopes also provide
information on neutrino properties including clear evidence for neutrino flavor
change. Telescopes in operation in the past and present are described, along
with plans for future instruments to expand this rapidly growing field of
particle astrophysics.Comment: 28 pages, 31 figures, Invited review article submitted to Review of
Scientific Instruments May 19, 200
Novel therapies for children with acute myeloid leukaemia
Significant improvements in survival for children with acute myeloid leukaemia (AML) have been made over the past three decades, with overall survival rates now approximately 60-70%. However, these gains can be largely attributed to more intensive use of conventional cytotoxics made possible by advances in supportive care, and although over 90% of children achieve remission with frontline therapy, approximately one third in current protocols relapse. Furthermore, late effects of therapy cause significant morbidity for many survivors. Novel therapies are therefore desperately needed. Early-phase paediatric trials of several new agents such as clofarabine, sorafenib and gemtuzumab ozogamicin have shown encouraging results in recent years. Due to the relatively low incidence of AML in childhood, the success of paediatric early-phase clinical trials is largely dependent upon collaborative clinical trial design by international cooperative study groups. Successfully incorporating novel therapies into frontline therapy remains a challenge, but the potential for significant improvement in the duration and quality of survival for children with AML is high
Abstract Learning Frameworks for Synthesis
We develop abstract learning frameworks (ALFs) for synthesis that embody the
principles of CEGIS (counter-example based inductive synthesis) strategies that
have become widely applicable in recent years. Our framework defines a general
abstract framework of iterative learning, based on a hypothesis space that
captures the synthesized objects, a sample space that forms the space on which
induction is performed, and a concept space that abstractly defines the
semantics of the learning process. We show that a variety of synthesis
algorithms in current literature can be embedded in this general framework.
While studying these embeddings, we also generalize some of the synthesis
problems these instances are of, resulting in new ways of looking at synthesis
problems using learning. We also investigate convergence issues for the general
framework, and exhibit three recipes for convergence in finite time. The first
two recipes generalize current techniques for convergence used by existing
synthesis engines. The third technique is a more involved technique of which we
know of no existing instantiation, and we instantiate it to concrete synthesis
problems
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