Crystallization and preliminary X-ray diffraction studies of d(ACGTAGCTACGT)2:[actinomycin D, (echinomycin)2] and d(ACGTAGCTACGT)2: [actinomycin D, (triostin A)2] complexes

This is the publisher's version, also available electronically from http://scripts.iucr.org/cgi-bin/paper?S0907444999016790.A DNA-multiple drug complex, d(ACGTAGCTACGT)2:[actinomycin D, (echinomycin)2] has been crystallized. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 85.6, b = 72.8, c = 56.6 Å, [beta] = 101.5° at 93 K and Z = 8. The crystal diffracted to 3.0 Å resolution along the DNA fiber axis and to 3.5 Å resolution in other directions. The Patterson maps indicate that all complexes in the crystal are oriented along their helical axes in the [10\bar 1] direction

Preacher\u27s Magazine Volume 51 Number 11

The Use and Abuse of Language, Editorial The Bankruptcy of Unbelief, Pascal P. Belew Watching the Wicked Succeed, William Goodman Telegrams, Wedding Cakes, and Squares, Albert J. Lown Making Hospital Calls Count, C. D. Hansen The Pastoral Leader in a Mission-oriented Church, John P. Ragsdale True and False Liberation from the “Numbers Game,” Richard S. Taylor Social Security: Cause for Concern, Not Alarm, Dean Wessels Teamwork in Staff Relations, Practical Points A Parade of Preachers’ Wives, Frances Simpson Predestination, Sinlessness, and Imputation, George E. Failing Church Leadership Misfit, Raymond Kratzer Publicize Contacts (Ideas), Betty B. Robertson The Starting Point, C. Neil Strait Seeds for Sermons, Mendell Taylor Gleanings from the Greek, Ralph Earle DEPARTMENTS Preacher’s Wife Wesleyana In the Study Timely Outlines Here and There Among Books Preachers’ Exchangehttps://digitalcommons.olivet.edu/cotn_pm/1592/thumbnail.jp

Preacher\u27s Magazine Volume 51 Number 11

The Use and Abuse of Language, Editorial The Bankruptcy of Unbelief, Pascal P. Belew Watching the Wicked Succeed, William Goodman Telegrams, Wedding Cakes, and Squares, Albert J. Lown Making Hospital Calls Count, C. D. Hansen The Pastoral Leader in a Mission-oriented Church, John P. Ragsdale True and False Liberation from the “Numbers Game,” Richard S. Taylor Social Security: Cause for Concern, Not Alarm, Dean Wessels Teamwork in Staff Relations, Practical Points A Parade of Preachers’ Wives, Frances Simpson Predestination, Sinlessness, and Imputation, George E. Failing Church Leadership Misfit, Raymond Kratzer Publicize Contacts (Ideas), Betty B. Robertson The Starting Point, C. Neil Strait Seeds for Sermons, Mendell Taylor Gleanings from the Greek, Ralph Earle DEPARTMENTS Preacher’s Wife Wesleyana In the Study Timely Outlines Here and There Among Books Preachers’ Exchangehttps://digitalcommons.olivet.edu/cotn_pm/1592/thumbnail.jp

Optical and thermal infrared observations of six near-Earth asteroids in 2002

We present thermal infrared photometry and spectrophotometry of six Near-Earth Asteroids (NEAs) using the 3.8 in United Kingdom Infrared Telescope (UKIRT) together with quasi-simultaneous optical observations of five NEAs taken at the 1.0 m Jacobus Kapteyn Telescope (JKT). For Asteroid (6455) 1992 HE we derive a rotational period P = 2.736 +/- 0.002 h, and an absolute visual magnitude H = 14.32 +/- 0.24. For Asteroid 2002 HK12 we derive H = 18.22 (+0.37 -0.30). The Standard Thermal Model (STM), the Fast Rotating Model (FIRM) and the Near-Earth Asteroid Thermal Model (NEATM) have been fitted to the measured fluxes to derive albedos and effective diameters. The derived geometric albedos and effective diameters are (6455) 1992 HE: p(v) = 0.26 +/- 0.08, D-eff = 3.55 +/- 0.5 km; 1999 HF1: p(v) = 0.18 +/- 0.07, D-eff = 3.73 (+1.0. -0.5) km; 2000 ED104: p(v) = 0.18 +/- 0.05, D-eff = 1.21 +/- 0.2 km: 2002 HK12: p(v) = 0.24 (+0.25. -0.11), D-eff 0.62 +/- 0.2 km: 2002 NX18: p(v) = 0.031 +/- 0.009 D-eff = 2.24 +/- 0.3 km; 2002 QE(15): p(v) = 0.15 (+0.08, -0.06), D-eff = 1.94 +/- 0.4 km. The limitations of using the NEATM to observe NEAs at high phase angles are discussed. (c) 2004 Elsevier Inc. All rights reserved

Loran-C time difference calculations

Some of the simpler mathematical equations which may be used in Loran-C navigation calculations were examined. A technique is presented to allow Loran-C time differences to be predicted at a location. This is useful for receiver performance work, and a tool for more complex calculations, such as position fixing

Remote sensing of vigor loss in conifers due to dwarf mistletoe

The initial operation of a multiband/multidate tower-tramway test site in northeastern Minnesota for the development of specifications for subsequent multiband aerial photography of more extensive study areas was completed. Multiband/multidate configurations suggested by the tower-tramway studies were and will be flown with local equipment over the Togo test site. This site was photographed by the NASA RB57F aircraft in August and September 1971. It appears that, of all the film/filter combinations attempted to date (including optical recombining of several spectral band images via photo enhancement techniques), Ektachrome infrared film with a Wratten 12 filter is the best for detecting dwarf mistletoe, and other tree diseases as well. Using this film/filter combination, infection centers are easily detectable even on the smallest photo scale (1:100,000) obtained on the Togo site

Sexual Orientation Differences in the Relationship Between Victimization and Hazardous Drinking Among Women in the National Alcohol Survey

This study examined relationships between past experiences of victimization (sexual abuse and physical abuse in childhood, sexual abuse and physical abuse in adulthood, and lifetime victimization) and hazardous drinking among sexual minority women compared to exclusively heterosexual women. Data were from 11,169 women responding to sexual identity and sexual behavior questions from three National Alcohol Survey waves: 2000 (n = 3,880), 2005 (n = 3,464), and 2010 (n = 3,825). A hazardous drinking index was constructed from five dichotomous variables (5+ drinking in the past year, drinking two or more drinks daily, drinking to intoxication in the past year, two or more lifetime dependence symptoms, and two or more lifetime drinking-related negative consequences). Exclusively heterosexual women were compared with three groups of sexual minority women: lesbian, bisexual, and women who identified as heterosexual but reported same-sex partners. Each of the sexual minority groups reported significantly higher rates of lifetime victimization (59.1% lesbians, 76% bisexuals, and 64.4% heterosexual women reporting same-sex partners) than exclusively heterosexual women (42.3%). Odds for hazardous drinking among sexual minority women were attenuated when measures of victimization were included in the regression models. Sexual minority groups had significantly higher odds of hazardous drinking, even after controlling for demographic and victimization variables: lesbian (OR [sub]adj[sub] = 2.0, CI = 1.1–3.9, p \u3c .01; bisexual (OR [sub]adj[sub] = 1.8, CI = 1.0–3.3, p \u3c .05; heterosexual with same-sex partners (ORadj = 2.7; CI = 1.7–4.3, p \u3c .001). Higher rates of victimization likely contribute to, but do not fully explain, higher rates of hazardous drinking among sexual minority women. (PsycINFO Database Record (c) 2013 APA, all rights reserved) (journal abstract)

Survival after chemotherapy and/or radiotherapy versus self-expanding metal stent insertion in the setting of inoperable esophageal cancer: a case-control study

<p>Abstract</p> <p>Background</p> <p>Our aim was to compare survival of the various treatment modality groups of chemotherapy and/or radiotherapy in relation to SEMS (self-expanding metal stents) in a retrospective case-control study. We have made the hypothesis that the administration of combined chemoradiotherapy improves survival in inoperable esophageal cancer patients.</p> <p>Methods</p> <p>All patients were confirmed histologically as having surgically non- resectable esophageal carcinoma. Included were patients with squamous cell carcinoma, undifferentiated carcinoma as well as Siewert type I--but not type II - esophagogastric junctional adenocarcinoma. The decision to proceed with palliative treatments was taken within the context of a multidisciplinary team meeting and full expert review based on patient's wish, co-morbid disease, clinical metastases, distant metastases, M1 nodal metastases, T4-tumor airway, aorta, main stem bronchi, cardiac invasion, and peritoneal disease. Patients not fit enough to tolerate a radical course of definitive chemo- and/or radiation therapy were referred for self-expanding metal stent insertion. Our approach to deal with potential confounders was to match subjects according to their clinical characteristics (contraindications for surgery) and tumor stage according to diagnostic work-up in four groups: SEMS group (A), Chemotherapy group (B), Radiotherapy group (C), and Chemoradiotherapy group (D).</p> <p>Results</p> <p>Esophagectomy was contraindicated in 155 (35.5%) out of 437 patients presenting with esophageal cancer to the Department of General and Abdominal Surgery of the University Hospital of Mainz, Germany, between November 1997 and November 2007. There were 133 males and 22 females with a median age of 64.3 (43-88) years. Out of 155 patients, 123 were assigned to four groups: SEMS group (A) n = 26, Chemotherapy group (B) n = 12, Radiotherapy group (C) n = 23 and Chemoradiotherapy group (D) n = 62. Mean patient survival for the 4 groups was as follows: Group A: 6.92 ± 8.4 months; Group B: 7.75 ± 6.6 months; Group C: 8.56 ± 9.5 months, and Group D: 13.53 ± 14.7 months. Significant differences in overall survival were associated with tumor histology (<it>P </it>= 0.027), tumor localization (<it>P </it>= 0.019), and type of therapy (<it>P </it>= 0.005), respectively, in univariate analysis. Treatment modality (<it>P </it>= 0.043) was the only independent predictor of survival in multivariate analysis. The difference in overall survival between Group A and Group D was highly significant (<it>P </it>< 0.01) and in favor of Group D. As concerns Group D versus Group B and Group D versus Group C there was a trend towards a difference in overall survival in favor of Group D (<it>P </it>= 0.069 and <it>P </it>= 0.059, respectively).</p> <p>Conclusions</p> <p>The prognosis of inoperable esophageal cancer seems to be highly dependent on the suitability of the induction of patient-specific therapeutic measures and is significantly better, when chemoradiotherapy is applied.</p