Direct and secondary nuclear excitation with x-ray free-electron lasers

The direct and secondary nuclear excitation produced by an x-ray free electron laser when interacting with a solid-state nuclear target is investigated theoretically. When driven at the resonance energy, the x-ray free electron laser can produce direct photoexcitation. However, the dominant process in that interaction is the photoelectric effect producing a cold and very dense plasma in which also secondary processes such as nuclear excitation by electron capture may occur. We develop a realistic theoretical model to quantify the temporal dynamics of the plasma and the magnitude of the secondary excitation therein. Numerical results show that depending on the nuclear transition energy and the temperature and charge states reached in the plasma, secondary nuclear excitation by electron capture may dominate the direct photoexcitation by several orders of magnitude, as it is the case for the 4.8 keV transition from the isomeric state of $^{93}$Mo, or it can be negligible, as it is the case for the 14.4 keV M\"ossbauer transition in $^{57}\mathrm{Fe}$. These findings are most relevant for future nuclear quantum optics experiments at x-ray free electron laser facilities.Comment: 17 pages, 7 figures; minor corrections made; accepted by Physics of Plasma

Wall Effects in Cavity Flows and their Correction Rules

The wall effects in cavity flows have been long recognized to be more important and more difficult to determine than those in single-phase, nonseparated flows. Earlier theoretical investigations of this problem have been limited largely to simple body forms in plane flows, based on some commonly used cavity-flow models, such as the Riabouchinsky, the reentrant jet, or the linearized flow model, to represent a finite cavity. Although not meant to be exhaustive, references may be made to Cisotti (1922), Birkhoff, Plesset and Simmons (1950, 1952), Gurevich (1953), Cohen et al. (1957, 1958), and Fabula (1964). The wall effects in axisymmetric flows with a finite cavity has been evaluated numerically by Brennen (1969) for a disk and a sphere. Some intricate features of the wall effects have been noted in experimental studies by Morgan (1966) and Dobay (1967). Also, an empirical method for correcting the wall effect has been proposed by Meijer (1967). The presence of lateral flow boundaries in a closed water tunnel introduces the following physical effects: (i) First, in dealing with the part of irrotational flow outside the viscous region, these flow boundaries will impose a condition on the flow direction at the rigid tunnel walls. This "streamline-blocking" effect will produce extraneous forces and modifications of cavity shape. (ii) The boundary layer built up at the tunnel walls may effectively reduce the tunnel cross-sectional area, and generate a longitudinal pressure gradient in the working section, giving rise to an additional drag force known as the "horizontal buoyancy." (iii) The lateral constraint of tunnel walls results in a higher velocity outside the boundary layer, and hence a greater skin friction at the wetted body surface. (iv) The lateral constraint also affects the spreading of the viscous wake behind the cavity, an effect known as the "wake-blocking." (v) It may modify the location of the "smooth detachment" of cavity boundary from a continuously curved body. In the present paper, the aforementioned effect (i) will be investigated for the pure-drag flows so that this primary effect can be clarified first. Two cavity flow models, namely, the Riabouchinsky and the open-wake (the latter has been attributed, independently, to Joukowsky, Roshko, and Eppler) models, are adopted for detailed examination. The asymptotic representations of these theoretical solutions, with the wall effect treated as a small correction to the unbounded-flow limit, have yielded two different wall-correction rules, both of which can be applied very effectively in practice. It is of interest to note that the most critical range for comparison of these results lies in the case when the cavitating body is slender, rather than blunt ones, and when the cavity is short, instead of very long ones in the nearly choked-flow state. Only in this critical range do these flow models deviate significantly from each other, thereby permitting a refined differentiation and a critical examination of the accuracy of these flow models in representing physical flows. A series of experiments carefully planned for this purpose has provided conclusive evidences, which seem to be beyond possible experimental uncertainties, that the Riabouchinsky model gives a very satisfactory agreement with the experimental results, and is superior to other models, even in the most critical range when the wall effects are especially significant and the differences between these theoretical flow models become noticeably large. These outstanding features are effectively demonstrated by the relatively simple case of a symmetric wedge held in a non-lifting flow within a closed tunnel, which we discuss in the sequel

Assessment of the NPP VIIRS RVS for the Thermal Emissive Bands Using the First Pitch Maneuver Observations

The Visible Infrared Imaging Radiometer Suite (VIIRS) is a key sensor carried on Suomi NPP (National Polar-orbiting Partnership) satellite (http://npp.gsfc.nasa.gov/viirs.html) (launched in October 2011). VIIRS sensor design draws on heritage instruments including AVHRR, OLS, SeaWiFS and MODIS. It has on-board calibration components including a solar diffuser (SD) and a solar diffuser stability monitor (SDSM) for the reflective solar bands (RSB), a V-groove blackbody for the thermal emissive bands (TEB), and a space view (SV) port for background subtraction. These on-board calibrators are located at fixed scan angles. The VIIRS response versus scan angle (RVS) was characterized prelaunch in lab ambient conditions and is currently used to characterize the on-orbit response for all scan angles relative to the calibrator scan angle (SD for RSB and blackbody for TEB). Since the RVS is vitally important to the quality of calibrated radiance products, several independent studies were performed to analyze the prelaunch RVS measurement data. A spacecraft level pitch maneuver was scheduled during the first three months of intensive Cal/Val. The NPP pitch maneuver provided a rare opportunity for VIIRS to make observations of deep space over the entire range of scan angles, which can be used to characterize the TEB RVS. This study will provide our analysis of the pitch maneuver data and assessment of the derived TEB RVS. A comparison between the RVS determined by the pitch maneuver observations and prelaunch lab tests will be conducted for each band, detector, and half angle mirror (HAM) sid

A current disruption mechanism in the neutral sheet for triggering substorm expansions

Two main areas were addressed in support of an effort to understand mechanism responsible for the broadband electrostatic noise (BEN) observed in the magnetotail. The first area concerns the generation of BEN in the boundary layer region of the magnetotail whereas the second area concerns the occassional presence of BEN in the neutral sheet region. For the generation of BEN in the boundary layer region, a hybrid simulation code was developed to perform reliable longtime, quiet, highly resolved simulations of field aligned electron and ion beam flow. The result of the simulation shows that broadband emissions cannot be generated by beam-plasma instability if realistic values of the ion beam parameters are used. The waves generated from beam-plasma instability are highly discrete and are of high frequencies. For the plasma sheet boundary layer condition, the wave frequencies are in the kHz range, which is incompatible with the observation that the peak power in BEN occur in the 10's of Hz range. It was found that the BEN characteristics are more consistent with lower hybrid drift instability. For the occasional presence of BEN in the neutral sheet region, a linear analysis of the kinetic cross-field streaming instability appropriate to the neutral sheet condition just prior to onset of substorm expansion was performed. By solving numerically the dispersion relation, it was found that the instability has a growth time comparable to the onset time scale of substorm onset. The excited waves have a mixed polarization in the lower hybrid frequency range. The imposed drift driving the instability corresponds to unmagnetized ions undergoing current sheet acceleration in the presence of a cross-tail electric field. The required electric field strength is in the 10 mV/m range which is well within the observed electric field values detected in the neutral sheet during substorms. This finding can potentially account for the disruption of cross-tail current and its diversion to the ionosphere to form the substorm current wedge. Furthermore, a number of features associated with substorm expansion onset can be understood based on this substorm onset scenario

Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression.

Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that drive these epigenetic changes remain unknown. Lymphoid-specific helicase (HELLS) protein is an epigenetic modifier directly regulated by the RB/E2F pathway. In this study, we used novel genetically engineered mouse models to investigate the role of HELLS during retinal development and tumorigenesis. Our results indicate that Hells-null retinal progenitor cells divide, undergo cell-fate specification, and give rise to fully laminated retinae with minor bipolar cells defects, but normal retinal function. Despite the apparent nonessential role of HELLS in retinal development, failure to transcriptionally repress Hells during retinal terminal differentiation due to retinoblastoma (RB) family loss significantly contributes to retinal tumorigenesis. Loss of HELLS drastically reduced ectopic division of differentiating cells in Rb1/p107-null retinae, significantly decreased the incidence of retinoblastoma, delayed tumor progression, and increased overall survival. Despite its role in heterochromatin formation, we found no evidence that Hells loss directly affected chromatin accessibility in the retina but functioned as transcriptional co-activator of E2F3, decreasing expression of cell cycle genes. We propose that HELLS is a critical downstream mediator of E2F-dependent ectopic proliferation in RB-null retinae. Together with the nontoxic effect of HELLS loss in the developing retina, our results suggest that HELLS and its downstream pathways could serve as potential therapeutic targets for retinoblastoma

Studying RFID adoption by SMES in the Taiwanese IT industry

With the advent of Radio Frequency Identification (RFID), organisations have the opportunity to rethink how their organisation will operate and integrate in the supply chain. Especially for Small to Medium Sized Enterprises (SMEs), that they have limited resources adopting such an innovative technology (i.e. RFID) can be daunting. Literature indicates that SMEs that deal with implementation have so far only a few guidelines regarding specific opportunities and risks. This research is therefore trying to fill the gap by employing Exploratory Factor Analysis (EFA) techniques and utilising a questionnaire survey with the aim of exploring the factors that affect SMEs’ RFID adoption in the Taiwan Information Technology (IT) manufacturing industry. In doing so, the adoption factors which are classified into 3 different adopters categories named ready adopter (cost and management), initiator adopter (competitiveness and process efficiency) and unprepared adopter (IT management difficulties, IT implementation difficulties and cost of implementation) using EFA technique. A SMEs RFID adoption model is then proposed. It is anticipated that the findings of this research will not only enhance the research in RFID adoption in SMEs, but can also act as a reference for practitioners in the industry and researchers in the academic field