Bridges in three-dimensional granular packings: experiments and simulations

In this letter, we present the first experimental study of bridge structures in three-dimensional dry granular packings. When bridges are small, they are predominantly 'linear', and have an exponential size distribution. Larger, predominantly 'complex' bridges, are confirmed to follow a power-law size distribution. Our experiments, which use X-ray tomography, are in good agreement with the simulations presented here, for the distribution of sizes, end-to-end lengths, base extensions and orientations of predominantly linear bridges. Quantitative differences between the present experiment and earlier simulations suggest that packing fraction is an important determinant of bridge structure.Comment: 6 pages, 7 figures, accepted by EPL (2013

Discovery and Timing analysis of new pulsars in globular cluster NGC 5024: new observations from FAST

NGC 5024 (M53) is the most distant globular cluster (GC) with known pulsars. In this study, we report the discovery of a new binary millisecond pulsar PSR J1312+1810E (M53E) and present the new timing solutions for M53B to M53E, based on 22 observations from the Five-hundred-meter Aperture Spherical radio Telescope (FAST).These discoveries and timing work benefit from FAST's high sensitivity. We find that M53C is the only isolated millisecond pulsar known in this distant globular cluster, with a spin period of 12.53 ms and spin period derivative of $5.26 \times 10^{-20} \, \rm s \; s^{-1}$. Our results reveal the orbital periods of 47.7, 5.8, and 2.4 days for M53B, D, and E, respectively. The companions, with a mass of 0.25, 0.27, and 0.18 ${\rm M}_\odot$, respectively, are likely to be white dwarf stars; if they are extended objects, they don't eclipse the pulsars. We find no X-ray counterparts for these millisecond pulsars in archival $Chandra$ images in the band of 0.3-8 keV. The characteristics of this pulsar population are similar to the population of millisecond pulsars in the Galactic disk, as expected from the low stellar density of M53.Comment: 10 pages, 4 figures, accepted for publication in ApJ

A multi-arm bandit neighbourhood search for routing and scheduling problems

Abstract Local search based meta-heuristics such as variable neighbourhood search have achieved remarkable success in solving complex combinatorial problems. Local search techniques are becoming increasingly popular and are used in a wide variety of meta-heuristics, such as genetic algorithms. Typically, local search iteratively improves a solution by making a series of small moves. Traditionally these methods do not employ any learning mechanism. We treat the selection of a local search neighbourhood as a dynamic multi- armed bandit (D-MAB) problem where learning techniques for solving the D-MAB can be used to guide the local search process. We present a D-MAB neighbourhood search (D-MABNS) which can be embedded within any meta- heuristic or hyperheuristic framework. Given a set of neighbourhoods, the aim of D-MABNS is to adapt the search sequence, testing promising solutions rst. We demonstrate the eectiveness of D-MABNS on two vehicle routing and scheduling problems, the real-world geographically distributed mainte- nance problem (GDMP) and the periodic vehicle routing problem (PVRP). We present comparisons to benchmark instances and give a detailed analysis of parameters, performance and behaviour. Keywords Meta-heuristic Local search Vehicle routin

Manipulating the fluorescence lifetime at the sub-cellular scale via photo-switchable barcoding

Fluorescent barcoding is a pivotal technique for the investigation of the microscale world, from information storage to the monitoring of dynamic biochemical processes. Using fluorescence lifetime as the readout modality offers more reproducible and quantitative outputs compared to conventional fluorescent barcoding, being independent of sample concentration and measurement methods. However, the use of fluorescence lifetime in this area has been limited by the lack of strategies that provide spatiotemporal manipulation of the coding process. In this study, we design a two-component photo-switchable nanogel that exhibits variable fluorescence lifetime upon photoisomerization-induced energy transfer processes through light irradiation. This remotely manipulated fluorescence lifetime property could be visually mapped using fluorescence lifetime imaging microscopy (FLIM), allowing selective storage and display of information at the microscale. Most importantly, the reversibility of this system further provides a strategy for minimizing the background influence in fluorescence lifetime imaging of live cells and sub-cellular organelles. Using fluorescence lifetime as the readout modality offers more reproducible and quantitative outputs compared to conventional fluorescent barcoding, being independent of sample concentration and measurement methods. Here, the authors design a photo-switchable nanogel exhibiting variable fluorescence lifetime, and demonstrate visual mapping by using fluorescence lifetime imaging microscopy on a sub-cellular scale.This work was supported by the ERC (grant number 615142), EPSRC, and the University of Birmingham, the Ministerio de Economia y Competitividad (MINECO) of Spain (project CTQ2016-80375-P) and the Basque Government (grant IT-324-07). The authors acknowledge the computational and technical and human support provided by DIPC. Y.X. acknowledges Chancellor's International Scholarship (University ofWarwick) for funding. All three reviewers are thanked for their time and contribution to the final version of this paper

Functional nanostructures by NiCCo-PISA of helical poly(aryl isocyanide) copolymers

Herein, we present a straightforward and versatile methodology to achieve functional polymeric nano-objects that contain helical cores. Nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers was..

Octet Quark Contents from SU(3) Flavor Symmetry

With the parametrization of parton distribution functions (PDFs) of the proton by Soffer \textit{et al.}, we extend the valence quark contents to other octet baryons by utilizing SU(3) flavor symmetry. We find the method practically useful. Fragmentation functions (FFs) are further obtained through the phenomenological Gribov-Lipatov relation at the $x \to 1$ region. Our results are compared with different models, and these different predictions can be discriminated by upcoming experiments.Comment: 6 pages, 5 figures, final version for journal publicatio

Highly Efficient and Selective Photocatalytic Nonoxidative Coupling of Methane to Ethylene over Pd-Zn Synergistic Catalytic Sites

Photocatalytic nonoxidative coupling of CH4 to multicarbon (C2+) hydrocarbons (e.g., C2H4) and H2 under ambient conditions provides a promising energy-conserving approach for utilization of carbon resource. However, as the methyl intermediates prefer to undergo self-coupling to produce ethane, it is a challenging task to control the selective conversion of CH4 to higher value-added C2H4. Herein, we adopt a synergistic catalysis strategy by integrating Pd-Zn active sites on visible light-responsive defective WO3 nanosheets for synergizing the adsorption, activation, and dehydrogenation processes in CH4 to C2H4 conversion. Benefiting from the synergy, our model catalyst achieves a remarkable C2+ compounds yield of 31.85 mu mol center dot g-1 center dot h-1 with an exceptionally high C2H4 selectivity of 75.3% and a stoichiometric H2 evolution. In situ spectroscopic studies reveal that the Zn sites promote the adsorption and activation of CH4 molecules to generate methyl and methoxy intermediates with the assistance of lattice oxygen, while the Pd sites facilitate the dehydrogenation of methoxy to methylene radicals for producing C2H4 and suppress overoxidation. This work demonstrates a strategy for designing efficient photocatalysts toward selective coupling of CH4 to higher value-added chemicals and highlights the importance of synergistic active sites to the synergy of key steps in catalytic reactions.Peer reviewe

2D Hierarchical Microbarcodes with Expanded Storage Capacity for Optical Multiplex and Information Encryption

The design of nanosegregated fluorescent tags/barcodes by geometrical patterning with precise dimensions and hierarchies could integrate multilevel optical information within one carrier and enhance microsized barcoding techniques for ultrahigh-density optical data storage and encryption. However, precise control of the spatial distribution in micro/nanosized matrices intrinsically limits the accessible barcoding applications in terms of material design and construction. Here, crystallization forces are leveraged to enable a rapid, programmable molecular packing and rapid epitaxial growth of fluorescent units in 2D via crystallization-driven self-assembly. The fluorescence encoding density, scalability, information storage capacity, and decoding techniques of the robust 2D polymeric barcoding platform are explored systematically. These results provide both a theoretical and an experimental foundation for expanding the fluorescence storage capacity, which is a longstanding challenge in state-of-the-art microbarcoding techniques and establish a generalized and adaptable coding platform for high-throughput analysis and optical multiplexing

Childhood Adversity Is Associated With Increased KITLG Methylation in Healthy Individuals but Not in Bipolar Disorder Patients

Background: Childhood adversity increases the risk of a range of mental disorders including bipolar disorder, but the underlying mechanisms are still unknown. Previous studies identified DNA methylation levels at the cg27512205 locus on the KIT Ligand (KITLG) gene as a mediator between childhood adversity and stress responsivity. This raises the question whether this locus also plays a role in stress related disorders such as bipolar disorder. Therefore, the current study aims to compare the level of KITLG (cg27512205) methylation between bipolar patients and healthy individuals and its relation to childhood adversity.Methods:KITLG (cg27512205) methylation was measured in 50 bipolar disorder patients and 91 healthy control participants using the HumanMethylation450K BeadChip platform. Childhood adversity in each individual was assessed using the Childhood Trauma Questionnaire. Analyses of the association of KITLG methylation with bipolar disorder, the association of childhood adversity with bipolar disorder as well as the association of KITLG methylation with childhood adversity in bipolar patients and controls were conducted using linear regression with age, gender, childhood adversity, smoking, and cell-type composition estimates as covariates.Results:KITLG (cg27512205) methylation level was significantly lower in bipolar disorder patients (β = −0.351, t = −6.316 p < 0.001). Childhood adversity levels were significantly higher in the bipolar disorder group (β = 4.903, t = 2.99, p = 0.003). In the bipolar disorder patients KITLG methylation was not associated with childhood adversity (β = 0.004, t = 1.039, p = 0.304) in contrast to the healthy controls (β = 0.012, t = 3.15, p = 0.002).Conclusions:KITLG methylation was lower in bipolar disorder despite high levels of childhood adversity, whereas childhood adversity was associated with higher KITLG methylation in healthy controls. In addition to lower methylation at this locus there is an indication that failure to adjust KITLG methylation to high levels of childhood adversity is a risk factor for bipolar disorder