159 research outputs found
Respiratory symptoms (COPD Assessment Test and modified Medical Research Council dyspnea scores) and GOLD-ABCD COPD classification: the LASSYC study
Chronic obstructive pulmonary disease; Symptoms; COPDEnfermedad pulmonar obstructiva crĂłnica; SĂntomas; EPOCMalaltia pulmonar obstructiva crĂČnica; SĂmptomes; MPOCObjective
To assess the frequency and severity of 24-hour respiratory symptoms according to COPD GOLD-ABCD classification (2017-version), the distribution of the patients with COPD into GOLD categories using mMRC (â„2) or CAT (â„10) scores, and agreement between these cut-off points.
Methods
In this cross-sectional study (LASSYC study), 24-hour day respiratory symptoms were assessed by the Evaluating Respiratory Symptoms in COPD (E-RS) questionnaire, Nighttime Symptoms of COPD Instrument (NiSCI), Early Morning Symptoms of COPD Instrument (EMSCI), CAT and mMRC scores.
Results
Among the 734 patients with COPD, 61% were male, age 69.6±8.7 years, FEV1% post-BD 49.1±17.5%, mMRC 1.8±1.0 and CAT 15.3±.8.1. By mMRC 33.7% were group-A, 29.2% group-B, 10.2% group-C and 26.9% group-D. By CAT 22.3% were group-A, 41% group-B, 4.8% group-C and 31.9% group-D. Using the mMRC the severity of E-RS, NiSCI and EMSCI scores increased from group A to D. Using the CAT, the groups B and D had the higher scores. Agreement between mMRC and CAT was 89.5% (Kappa statistics=75.7%). For mMRC score of 2, CAT score of â„11 showed the maximum Youdenâs index (1.34). For mMRC score of 1, CAT score of â„9 and â„10 showed the maximum Youdenâs index (1.48).
Conclusion
GOLD COPD classification by CAT seems to better discriminate 24-hour symptoms. Results do not support the equivalent use of CATâ„10 and mMRCâ„2 for assessing symptoms.This observational study was funded by AstraZeneca Latin America. The funder had no input into the study design, analysis, or interpretation of the results
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Socioeconomic position and sedentary behavior in Brazilian adolescents: A life-course approach.
Socioeconomic position (SEP) is a potential correlate of sedentary behavior in adolescents. The aim of this study was to examine the associations between SEP and self-reported and objective measures of sedentary behavior in adolescents, using a life-course approach. Data from the 1993 Pelotas (Brazil) Birth Cohort Study were analyzed (N=5249). Cross-sectional and longitudinal associations between multiple SEP indicators (maternal education, family income, SEP composite, cumulative family income) at birth, 11, 15 and 18years, and five sedentary behavior outcomes (â„4h/day screen time; â„4h/day TV; â„2h/day computer; â„2h/day video game; â„12.7h/day objectively measured sedentary time) at 11, 15 and 18years, were examined. In cross-sectional analyses, higher SEP was positively associated with more screen time at ages 11 and 15years. There was a consistent and positive association between higher SEP with time spent using a computer, and with sedentary time assessed through accelerometry. SEP at birth had a positive and direct effect on screen, computer and total sedentary time at 18years. Participants in the highest cumulative income group had higher odds of high sedentary behavior in screen (OR: 2.40; 95% CI: 1.50-3.54), computer (OR: 7.35; 95% CI: 4.19-12.89) and total sedentary time (OR: 5.40; 95% CI: 3.53-10.35), respectively, compared with their counterparts with lower cumulative income. Our findings showed that SEP is an early determinant of sedentary behavior in adolescents
Adiposity, depression and anxiety: interrelationship and possible mediators
OBJECTIVES: To explore the association between adiposity, major depressive disorder and generalized anxiety disorder, and to assess the role of inflammation, diet quality and physical activity in this association. METHODS: We used data from 2,977 individuals from the 1993 Pelotas Cohort (Brazil) who attended the 18- and 22-year follow-ups. We assessed general obesity using body mass index, fat mass index, and abdominal obesity using waist circumference. Major Depressive Disorder and generalized anxiety disorder were assessed using the mini-international neuropsychiatric interview. C-reactive protein and interleukin-6 (IL-6) levels were used as a measure of inflammation; diet quality was estimated using the revised diet quality index, and physical activity was assessed by the International physical activity questionnaire (IPAQ, min/day). The association between adiposity and major depressive disorder and generalized anxiety disorder was assessed using logistic regression, and the natural indirect effect via the mediators was estimated using G-computation. RESULTS: General obesity assessed by body mass index (OR: 2.3; 95% CI:1.13; 4.85), fat mass index (OR: 2.6; 95%CI: 1.37; 4.83), and abdominal obesity (OR: 2.5; 95%CI: 1.18; 5.39) were associated with higher odds of major depressive disorder, whereas major depressive disorder was only associated with obesity assessed by body mass index (OR=1.9; 95% CI: 1.09; 3.46). Obesity and generalized anxiety disorder were not associated. C-reactive protein, diet quality and physical activity did not mediate the effect of obesity on major depressive disorder, and C-reactive protein mediated about 25% of the effect of major depressive disorder on adiposity. CONCLUSIONS: Depression, but not generalized anxiety disorder, is associated with adiposity in both directions, with a stronger evidence for the direction obesity-depression. Inflammation explains part of the effect of major depressive disorder on obesity but not the other way around. Further research should explore other mechanisms that could be involved in the association between obesity and depression
Violence against women, EspĂrito Santo, Brazil
OBJETIVO Estimar a prevalĂȘncia e os fatores associados Ă s violĂȘncias psicolĂłgica, fĂsica e sexual nas mulheres vĂtimas de violĂȘncia perpetrada pelo parceiro Ăntimo atendidas nos serviços de atenção primĂĄria. MĂTODOS Estudo transversal, realizado em 26 unidades de saĂșde do municĂpio de VitĂłria, no EspĂrito Santo, de março a setembro de 2014. Foram entrevistadas 991 usuĂĄrias de 20 a 59 anos. Para classificar as violĂȘncias psicolĂłgica, fĂsica e sexual foi utilizado o instrumento da Organização Mundial de SaĂșde sobre violĂȘncia contra a mulher e um questionĂĄrio foi elaborado para investigar as caracterĂsticas sociodemogrĂĄficas, comportamentais e de histĂłria familiar e de vida da mulher. As anĂĄlises estatĂsticas utilizadas foram: regressĂŁo de Poisson, teste exato de Fisher e Qui-quadrado. RESULTADOS As prevalĂȘncias observadas foram: psicolĂłgica 25,3% (IC95% 22,6â28,2); fĂsica 9,9% (IC95% 8,1â11,9) e sexual 5,7% (IC95% 4,3â7,3). A violĂȘncia psicolĂłgica manteve-se associada Ă escolaridade, situação conjugal, histĂłrico materno de violĂȘncia por parceiro Ăntimo, violĂȘncia sexual na infĂąncia e ter feito uso de drogas, enquanto a agressĂŁo fĂsica esteve relacionada Ă idade, escolaridade, situação conjugal e a histĂłria materna de violĂȘncia por parceiro Ăntimo. A violĂȘncia sexual foi mais frequente nas mulheres de menor renda e que sofreram abuso sexual na infĂąncia. CONCLUSĂES As violĂȘncias psicolĂłgica, fĂsica e sexual apresentaram alta magnitude entre as mulheres usuĂĄrias dos serviços de atenção primĂĄria de saĂșde. Fatores sociodemogrĂĄficos, comportamentais e experiĂȘncias pessoal e materna de violĂȘncia influenciam a ocorrĂȘncia do fenĂŽmeno.OBJECTIVE To estimate the prevalence and factors associated with psychological, physical and sexual violence in women victims of intimate partner violence assisted in the primary care services. METHODS This is a cross-sectional study, conducted in 26 health units in VitĂłria, State of EspĂrito Santo, from March to September 2014. We interviewed 991 women aged 20-59 years. To classify the psychological, physical and sexual violence, the World Health Organization instrument on violence against women was used and a questionnaire to investigate the sociodemographic, behavioral characteristics, and the womenâs family and life history was developed. The statistical analyzes used were Poisson regression, Fisherâs exact test and Chi-square. RESULTS The prevalence we observed were psychological 25.3% (95%CI 22.6â28.2); physical 9.9% (95%CI 8.1â11.9) and sexual 5.7% (95%CI 4.3â7.3). Psychological violence remained associated with education, marital status, maternal history of intimate partner violence, sexual violence in childhood and drug use, while physical assault was related to age, education, marital status and maternal history of intimate partner violence. Sexual violence occurred the most among women with low income, and victims of sexual violence in childhood. CONCLUSIONS Psychological, physical and sexual violence showed highly frequency among women assisted by primary care services. Sociodemographic and behavioral factors, personal experiences, and maternal violence influence the phenomenon
Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults: a cross-sectional analysis nested in a birth cohort.
BACKGROUND: Several studies have verified body fat distribution in association with pulmonary function (PF), mainly waist circumference, but few have used measures able to distinguish abdominal fat compartments. The present study aims to verify the association of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with PF measures. METHODS: In 1982, all hospital births occurring in Pelotas, Brazil, were identified and those livebirths have been followed. In 2012-13, the cohort participants were evaluated and VAT and SAT measured using ultrasound; forced expiratory volume in the first second (FEV1) or forced vital capacity (FVC) were patronized in z-scores stratified by sex. The associations were verified using crude and adjusted linear regressions. RESULTS: The present analyses comprised 3438 individuals (1721 women). VAT was inversely associated with spirometric parameters, in both crude and adjusted models. SAT showed inverse associations in the crude analyzes in males and a positive trend after adjustment, except for SAT and FVC in males. To each centimeter of VAT, mean adjusted FEV1 z-scores decreased 0.072 (95% CI -0.107; -0.036) in men and 0.127 (95% CI -0.164; -0.090) in women, and FVC z-scores decreased -0.075 (95% CI -0.111; -0.039) and 0.121 (95% CI -0.158; -0.083), in men and women, respectively. CONCLUSIONS: VAT has a consistent inverse association with FEV1 and FVC in both sexes. On the other hand, SAT showed inconsistent results with PF parameters
Adverse childhood experiences:Prevalence and related factors in adolescents of a Brazilian birth cohort
AbstractAdverse childhood experiences (ACEs) can affect people's health and wellbeing not only at the time the ACE is experienced, but also later in life. The majority of studies on ACEs are carried out in high-income countries and little is known about its prevalence in low and middle-income countries. Thus, the aim of this study was to assess the prevalence of ACEs, associations between ACEs and sociodemographic factors, and the interrelationship between types of ACEs in adolescents of a Brazilian birth cohort. Data from 3,951 adolescents (78.4% of the original cohort) from the 1993 Pelotas Cohort were analyzed. Seven types of ACEs were assessed in those up to 18 years old: physical abuse, sexual abuse, physical neglect, emotional neglect, domestic violence, parental separation and parental death. The most common ACE was parental separation (42%), followed by emotional neglect (19.7%) and domestic violence (10.3%). Approximately 85% of the adolescents experienced at least one ACE, and females reported a higher number of adversities. Several socioeconomic, demographic and family-related characteristics were associated with the occurrence of ACEs, e.g. non-white skin color, low family income, low maternal schooling, absence of mother's partner, maternal smoking, and poor maternal mental health. A strong interrelationship was observed among the ACEs, indicating clustering of risk. These aspects should be considered by health and social care professionals in the prevention and identification of childhood adversities
Physical activity levels objectively measured among older adults: a population-based study in a Southern city of Brazil
Abstract
Background
Low levels of physical activity are currently observed in all age groups around the world. Among older adults physical activity is even lower, potentially influencing quality of life, incidence of diseases and premature mortality. The aim of this study was to describe objectively measured physical activity levels among older adults residents in a Southern city of Brazil.
Methods
A population-based study was carried out including people aged 60+ years living in the urban area of Pelotas. Face-to-face interviews, anthropometric measures and triaxial accelerometry (non-dominant wrist) were used to collect sociodemographic, anthropometric and physical activity, respectively. For descriptive purposes, overall physical activity was expressed as daily averages of acceleration. Time spent in light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) using different bout criteria (non-bouted, and in 1-, 5- and 10-min bouts) were calculated. Crude and adjusted analyses were performed using simple linear regression to examine the association between physical activity and exposure variables.
Results
Overall, 971 individuals provided valid accelerometry data. Women spent on average more time on LPA (136.2 vs. 127.6Â min per day). Men and women respectively accumulated, in average, 64.5 and 56.7Â min per day of non-bouted MVPA, while these daily averages were 14.9 and 9.46Â min using 5-min, and 8.1 and 4.5Â min using 10-min bout MVPA. In adjusted analyses, men aged 80Â years or more spent in average 45Â min less LPA per day when compared to men 60-69 years and, among women, this difference was 65Â min. Considering time in 5-min MVPA bouts, the youngest age group and those with a better self-perceived health accumulated more MVPA. Specifically among men, socioeconomic status was inversely associated with 5-min bout MVPA.
Conclusion
The present study showed low levels of physical activity among Brazilian older adults, even lower in more advanced ages, and a different pattern for physical activity intensity between men and women
A Study of Sawara Marathon at Chiba Normal School
<p>FEV<sub>1</sub>: forced expiratory volume in the first second; BMI: body mass index; WC: waist circumference; FM: fat mass; FFM fat free mass. Adjusted by height, weight and skin color current asset index (quintiles), current achieved schooling, smoking status, wheezing in the last year, physical activity and corticoids use in the last three months, birth weight and maternal smoking during pregnancy. P-values for AâD plots: Waldâs test for heterogeneity; p-values for EâH plots: Waldâs test for linear tendency. First quintile: lowest values; fifth quintile: highest values (anthropometric and body composition variables)</p
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