13,134 research outputs found
Influence of spinal cord stimulation on evoked potentials by cutaneous electrical stimulation
In the past, limited research has been done to investigate the influence of spinal cord stimulation (SCS) for treatment of chronic pain on evoked potentials (EP). Further insight into the mechanism of SCS may provide explanations for unsatisfactory results with this therapy in certain subpopulations. It also might predict effectiveness of SCS. In previous research MEG responses were measured on median and tibial nerve stimulations in chronic pain patients with and without SCS (1). However, this stimulation method preferentially activates large myelinated proprioceptive fibres, leaving painrelated small fibres unrelated. We expect that the observation of pain processing is impaired by large amounts of non-painrelated activity
The Kata Kolok perfective in child signing: Coordination of manual and non-manual components
Kinship in Kata Kolok and Balinese: Differences between the signed and spoken language of a single village community
Introduction: Demographic, sociocultural, and linguistic variation across rural signing communities
Gene-culture coevolution of a linguistic system in two modalities
Complex communication can take place in a range of modalities such as auditory, visual, and tactile modalities. In a very general way, the modality that individuals use is constrained by their biological biases (humans cannot use magnetic fields directly to communicate to each other). The majority of natural languages have a large audible component. However, since humans can learn sign languages just as easily, it’s not clear to what extent the prevalence of spoken languages is due to biological biases, the social environment or cultural inheritance. This paper suggests that we can explore the relative contribution of these factors by modelling the spontaneous emergence of sign languages that are shared by the deaf and hearing members of relatively isolated communities. Such shared signing communities have arisen in enclaves around the world and may provide useful insights by demonstrating how languages evolve as the deaf proportion of its members has strong biases towards the visual language modality. In this paper we describe a model of cultural evolution in two modalities, combining aspects that are thought to impact the emergence of sign languages in a more general evolutionary framework. The model can be used to explore hypotheses about how sign languages emerge
Normal stresses in semiflexible polymer hydrogels
Biopolymer gels such as fibrin and collagen networks are known to develop
tensile axial stress when subject to torsion. This negative normal stress is
opposite to the classical Poynting effect observed for most elastic solids
including synthetic polymer gels, where torsion provokes a positive normal
stress. As recently shown, this anomalous behavior in fibrin gels depends on
the open, porous network structure of biopolymer gels, which facilitates
interstitial fluid flow during shear and can be described by a phenomenological
two-fluid model with viscous coupling between network and solvent. Here we
extend this model and develop a microscopic model for the individual diagonal
components of the stress tensor that determine the axial response of
semi-flexible polymer hydrogels. This microscopic model predicts that the
magnitude of these stress components depends inversely on the characteristic
strain for the onset of nonlinear shear stress, which we confirm experimentally
by shear rheometry on fibrin gels. Moreover, our model predicts a transient
behavior of the normal stress, which is in excellent agreement with the full
time-dependent normal stress we measure.Comment: 12 pages, 8 figure
Isolation and mapping of a C3'H gene (CYP98A49) from globe artichoke, and its expression upon UV-C stress
Globe artichoke represents a natural source of phenolic compounds with dicaffeoylquinic acids along with their biosynthetic precursor chlorogenic acid (5-caffeoylquinic acid) as the predominant molecules. We report the isolation and characterization of a full-length cDNA and promoter of a globe artichoke p-coumaroyl ester 3¿-hydroxylase (CYP98A49), which is involved in both chlorogenic acid and lignin biosynthesis. Phylogenetic analyses demonstrated that this gene belongs to the CYP98 family. CYP98A49 was also heterologously expressed in yeast, in order to perform an enzymatic assay with p-coumaroylshikimate and p-coumaroylquinate as substrates. Real Time quantitative PCR analysis revealed that CYP98A49 expression is induced upon exposure to UV-C radiation. A single nucleotide polymorphism in the CYP98A49 gene sequence of two globe artichoke varieties used for genetic mapping allowed the localization of this gene to linkage group 10 within the previously developed map
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