Mapping carcass and meat quality QTL on Sus Scrofa chromosome 2 in commercial finishing pigs

Quantitative trait loci (QTL) affecting carcass and meat quality located on SSC2 were identified using variance component methods. A large number of traits involved in meat and carcass quality was detected in a commercial crossbred population: 1855 pigs sired by 17 boars from a synthetic line, which where homozygous (A/A) for IGF2. Using combined linkage and linkage disequilibrium mapping (LDLA), several QTL significantly affecting loin muscle mass, ham weight and ham muscles (outer ham and knuckle ham) and meat quality traits, such as Minolta-L* and -b*, ultimate pH and Japanese colour score were detected. These results agreed well with previous QTL-studies involving SSC2. Since our study is carried out on crossbreds, different QTL may be segregating in the parental lines. To address this question, we compared models with a single QTL-variance component with models allowing for separate sire and dam QTL-variance components. The same QTL were identified using a single QTL variance component model compared to a model allowing for separate variances with minor differences with respect to QTL location. However, the variance component method made it possible to detect QTL segregating in the paternal line (e.g. HAMB), the maternal lines (e.g. Ham) or in both (e.g. pHu). Combining association and linkage information among haplotypes improved slightly the significance of the QTL compared to an analysis using linkage information only

Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation

BACKGROUND: Increasing robustness via improvement of resistance to pathogens is a major selection objective in livestock breeding. As resistance traits are difficult or impossible to measure directly, potential indirect criteria are measures of immune traits (ITs). Our underlying hypothesis is that levels of ITs with no focus on specific pathogens define an individual's immunocompetence and thus predict response to pathogens in general. Since variation in ITs depends on genetic, environmental and probably epigenetic factors, our aim was to estimate the relative importance of genetics. In this report, we present a large genetic survey of innate and adaptive ITs in pig families bred in the same environment. METHODOLOGY/PRINCIPAL FINDINGS: Fifty four ITs were studied on 443 Large White pigs vaccinated against Mycoplasma hyopneumoniae and analyzed by combining a principal component analysis (PCA) and genetic parameter estimation. ITs include specific and non specific antibodies, seric inflammatory proteins, cell subsets by hemogram and flow cytometry, ex vivo production of cytokines (IFNα, TNFα, IL6, IL8, IL12, IFNγ, IL2, IL4, IL10), phagocytosis and lymphocyte proliferation. While six ITs had heritabilities that were weak or not significantly different from zero, 18 and 30 ITs had moderate (0.1<h2≤0.4) or high (h2>0.4) heritability values, respectively. Phenotypic and genetic correlations between ITs were weak except for a few traits that mostly include cell subsets. PCA revealed no cluster of innate or adaptive ITs. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that variation in many innate and adaptive ITs is genetically controlled in swine, as already reported for a smaller number of traits by other laboratories. A limited redundancy of the traits was also observed confirming the high degree of complementarity between innate and adaptive ITs. Our data provide a genetic framework for choosing ITs to be included as selection criteria in multitrait selection programmes that aim to improve both production and health traits

Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

peer-reviewedH.D.D., A.J.C., P.J.B. and B.J.H. would like to acknowledge the Dairy Futures Cooperative Research Centre for funding. H.P. and R.F. acknowledge funding from the German Federal Ministry of Education and Research (BMBF) within the AgroClustEr ‘Synbreed—Synergistic Plant and Animal Breeding’ (grant 0315527B). H.P., R.F., R.E. and K.-U.G. acknowledge the Arbeitsgemeinschaft Süddeutscher Rinderzüchter, the Arbeitsgemeinschaft Österreichischer Fleckviehzüchter and ZuchtData EDV Dienstleistungen for providing genotype data. A. Bagnato acknowledges the European Union (EU) Collaborative Project LowInputBreeds (grant agreement 222623) for providing Brown Swiss genotypes. Braunvieh Schweiz is acknowledged for providing Brown Swiss phenotypes. H.P. and R.F. acknowledge the German Holstein Association (DHV) and the Confederación de Asociaciones de Frisona Española (CONCAFE) for sharing genotype data. H.P. was financially supported by a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft (DFG) (grant PA 2789/1-1). D.B. and D.C.P. acknowledge funding from the Research Stimulus Fund (11/S/112) and Science Foundation Ireland (14/IA/2576). M.S. and F.S.S. acknowledge the Canadian Dairy Network (CDN) for providing the Holstein genotypes. P.S. acknowledges funding from the Genome Canada project entitled ‘Whole Genome Selection through Genome Wide Imputation in Beef Cattle’ and acknowledges WestGrid and Compute/Calcul Canada for providing computing resources. J.F.T. was supported by the National Institute of Food and Agriculture, US Department of Agriculture, under awards 2013-68004-20364 and 2015-67015-23183. A. Bagnato, F.P., M.D. and J.W. acknowledge EU Collaborative Project Quantomics (grant 516 agreement 222664) for providing Brown Swiss and Finnish Ayrshire sequences and genotypes. A.C.B. and R.F.V. acknowledge funding from the public–private partnership ‘Breed4Food’ (code BO-22.04-011- 001-ASG-LR) and EU FP7 IRSES SEQSEL (grant 317697). A.C.B. and R.F.V. acknowledge CRV (Arnhem, the Netherlands) for providing data on Dutch and New Zealand Holstein and Jersey bulls.Stature is affected by many polymorphisms of small effect in humans1. In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10−8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP–seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals

Valorisation de sédiments fluviaux pollués traités en assises de chaussée

Le dragage des sédiments est nécessaire pour maintenir le transport fluvial mais les sédiments extraits sont souvent pollués. La société Solvay a mis au point un procédé pour les traiter et permettre ainsi d’envisager une valorisation : le procédé Novosol®. Celui-ci permet de fixer les métaux lourds mais aussi de détruire la matière organique. Les principales caractéristiques d’un sédiment traité et sa valorisation en techniques routières sont présentées dans cet article. D’un point de vue mécanique, les mélanges réalisés avec les sédiments sont conformes aux normes routières. Les tests environnementaux sur les matériaux incorporant les sédiments traités montrent que le relargage est similaire à celui sur matériaux témoins. L’ensemble de ces résultats permet d’envisager l’utilisation des sédiments traités Novosol® en techniques routières

De l’incertitude des savoirs aux nouvelles fabriques de l’expertise

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Crossing Professional Habits for more Global. Analysis of Urban Soundscapes

International audienceSoundscape standardisation is an actual question of sound research, specifically in human and social sciences. Some late works have revealed that standardisation of urban soundscapes is or may be a consequence of contemporary space design, specifically when it comes to environmental or commercial design. In this perspective and in order to prevent this possible standardisation, but also to go beyond a negative and curative approach of "noise" and towards a more qualitative and crossed/interdisciplinary approach, the "DIAGPART" research took place. Its goal was double: \n1. Scientific goal: better understand how the multiple stakeholders of urban soundscapes (acousticians, urban designers, applied researchers in human and social sciences, soundmakers, local stakeholders) mobilise soundscape in their everyday activities; highlight the tools, methods, approaches, formalisations mobilized by the different stakeholders of urban soundscapes during a soundscape analysis; and understand if and in which ways they (could) mobilise other approaches and disciplines in their activity.\n2. Operational goal: propose a tool to help on setting up a cross-disciplinary analysis of urban soundscapes, addressed to the different stakeholders (designers, researchers, inhabitants, local stakeholders…). \nIn order to answer these questions, in addition to a recension of the ways in which the different stakeholders approach atmospheres and soundscapes, 6 workshops of discussion and in situ experimentation were carried out, based on the focus group methodology, followed by a transversal seminar . \nThe results of this research are both related to scientific knowledge about the ways and means that urban soundscape analysis is carried out by the soundscape stakeholders, and to a collection of operational tools that the stakeholders can use in order to approach urban soundscapes in a more interdisciplinary and global way

Plant aggregates and fibers in earth construction materials: A review

International audienceEarth as a building material is increasingly being studied for its low environmental impact and its availability. Plant aggregates and fibers have been incorporated into the earth matrix in the aim of enhancing performance for thousands of years but scientific studies began quite recently. The present paper reviews the state of the art of research on the influence of these various natural and renewable resources in unfired earth materials such as compressed earth blocks, plasters, and extruded and stabilized blocks. This review, based on 50 major studies, includes characterization of the particles and treatments, and recapitulative tables of the material compositions, and the physical, mechanical, hygrothermal and durability performances of earth-based materials. A lack of references on hygroscopic and durability properties was observed. Future research orientations are thus suggested to promote and develop this type of sustainable material, which provides a solution for saving energy and natural resources. Highlights Earth-based products with plant aggregates as a sustainable material are reviewed. Physicochemical and mechanical properties of plant aggregates or fibers are reviewed. Mechanical, hygrothermal and durability performances of the composites are reviewed. Further investigations are needed to promote these materials

Croiser habitudes et expérimentations pour un diagnostic partagé du paysage sonore

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Croiser habitudes et expérimentations pour un diagnostic partagé du paysage sonore

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