Mobile Power Infrastructure Planning and Operational Management for Smart City Applications

The paper presents new strategies and algorithms for future mobile power infrastructure planning and operational management in smart cities. The efforts have been made to develop a resilient Electric Vehicle (EV) infrastructure for smart city applications. The goal of this work is to maximize the profit of utility and EV owners participating in real-time smart city energy market subjected to numerous techno-economic constraints of the EVs and power distribution system. For effective real-time applications, the knowledge of artificial intelligence and internet of things (IoT) are used in the proposed model. In order to validate the proposed model for smart city applications, IEEE 33-bus radial distribution network is adopted as a small city power network. The simulation results of proposed model are found to be encouraging when it is compared with the case in which conventional strategies are used

Optimal planning of hybrid energy conversion systems for annual energy cost minimization in Indian residential buildings

The increasing interest in renewables has encouraged power system planners to include the concept of hybrid energy systems in modern power industry. Besides, the modern power consumers are becoming more concerned about their energy bills which has led to the concept of hybrid energy management systems (HEMSs) for buildings to monitor, control and optimally manage energy consumptions without any waste. In this study, an optimal planning framework is proposed to determine optimal capacities and sharing of hybrid energy conversion systems (HECS) such as wind turbine, solar photovoltaic, battery energy storage and the utility grid. The objective is to maximize the net present value of the project/system which includes the cost of annual investment, operation and maintenance costs of HEMS expected to have incurred in the planning period. All the costs and parameters are considered in the Indian context, and Genetic Algorithm (GA) is adopted to solve this proposed planning framework. The simulation results obtained are compared with same obtained for conventional houses in India. The comparison shows that the proposed framework effectively reduces the electricity bills while improving its reliability

Short-term non-convex economic hydrothermal scheduling using dynamically controlled particle swarm optimization

Paper presented to the 3rd Southern African Solar Energy Conference, South Africa, 11-13 May, 2015.The aim of this paper is to present short-term hydrothermal scheduling (STHS) of power system. This problem is solved in such a way that utilizes available hydro reserves optimally and thus minimizes the fuel cost of thermal plants. A PSO based method is developed which can efficiently deals with hydro constraints like reservoir storage volume limits, water discharge rate limits, water dynamic balance, initial and final reservoir storage volume limits, etc. for a given time horizon. The operators of the PSO are dynamically controlled. Moreover, the cognitive and social behaviors of the swarm are modified for better exploration and exploitation of the search space. The effectiveness of the proposed method has been investigated on a standard test generating system considering several operational constraints pertaining to hydrothermal systems.dc201

Multi-area environmental economic dispatch with reserve constraints using enhanced particle swarm optimization

In this paper, the multi-area environmental economic dispatch (MAEED) problem with reserve constraints is solved by proposing an enhanced particle swarm optimization (EPSO) method. The objective of MAEED problem is to determine the optimal generating schedule of thermal units and inter-area power transactions in such a way that total fuel cost and emission are simultaneously optimized while satisfying tie-line, reserve, and other operational constraints. The spinning reserve requirements for reserve-sharing provisions are investigated by considering contingency and pooling spinning reserves. The control equation of the particle swarm optimization (PSO) is modified by improving the cognitive component of the particle's velocity using a new concept of a preceding experience. In addition, the operators of PSO are dynamically controlled to maintain a better balance between cognitive and social behavior of the swarm. The effectiveness of the proposed EPSO has been investigated on four areas, 16 generators and four areas, 40 generators test systems. The application results show that EPSO is very promising to solve the MAEED problem.http://www.tandfonline.com/loi/uemp202016-08-31hb2016Electrical, Electronic and Computer Engineerin

Multi-objective optimal DG allocation in distribution networks using bat algorithm

Paper presented to the 3rd Southern African Solar Energy Conference, South Africa, 11-13 May, 2015.The Distributed Generations (DGs) storage may store energy during solar energy peak and use it during peak demand. Proper allocation of DG storage is essential to extract maximum possible benefits. This paper introduces a Bat Algorithm (BA) for optimal allocation of DGs in radial distribution networks. The problem is formulated to maximize annual energy loss reduction and to maintain a better node voltage profile under a piece-wise linear variable load pattern using a penalty factor approach. The proposed method is applied on the benchmark IEEE 33-bus and 69-bus system available in literature and the results obtained are promising.dc201

RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease.

The therapeutic effects of l-3,4-dihydroxyphenylalanine (l-DOPA) in patients with Parkinson's disease (PD) severely diminishes with the onset of abnormal involuntary movement, l-DOPA-induced dyskinesia (LID). However, the molecular mechanisms that promote LID remain unclear. Here, we demonstrated that RasGRP1 [(guanine nucleotide exchange factor (GEF)] controls the development of LID. l-DOPA treatment rapidly up-regulated RasGRP1 in the striatum of mouse and macaque model of PD. The lack of RasGRP1 in mice (RasGRP1-/- ) dramatically diminished LID without interfering with the therapeutic effects of l-DOPA. Besides acting as a GEF for Ras homolog enriched in the brain (Rheb), the activator of the mammalian target of rapamycin kinase (mTOR), RasGRP1 promotes l-DOPA-induced extracellular signal-regulated kinase (ERK) and the mTOR signaling in the striatum. High-resolution tandem mass spectrometry analysis revealed multiple RasGRP1 downstream targets linked to LID vulnerability. Collectively, the study demonstrated that RasGRP1 is a critical striatal regulator of LID

Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial

AbstractBackgroundApproximately 30,000 people per annum undergo major, emergency abdominal, gastrointestinal surgery, of which 36% (~10,800) are carried out for emergency colorectal pathology. Approximately 14% of all patients requiring emergency surgery undergo laparoscopic surgery. AimsThe aims of the LaCeS feasibility trial (Laparoscopic versus Open Colorectal Surgery in the Acute Setting) were to assess the feasibility, safety and acceptability of performing a large-scale definitive phase III randomised controlled trial with a comparison of emergency laparoscopic with open surgery for acute colorectal pathology. MethodsLaCeS was designed as a prospective, multicentre, single blind, parallel group, pragmatic, randomised controlled feasibility trial with an integrated qualitative study. Randomisation was performed centrally with patients being randomised on a 1:1 basis between laparoscopic or open surgery. ResultsA total of 64 patients were recruited across 5 centres. The overall average steady state recruitment rate was 1.2 patients/month. Baseline compliance for clinical and HrQoL data was 99.8% and 93.8% respectively. The conversion rate from laparoscopic to open surgery was 39.4% (95% CI 22.9% – 57.9%). The 30 day post-operative complication rate was 27.3% (95% CI 13.3- 45.5) in the laparoscopic arm and 41.9% (95% CI 24.6 – 60.9) in the open arm. DiscussionThe LaCeS feasibility trial has demonstrated that it is possible to evaluate laparoscopic surgery in the emergency colorectal setting within the context of a randomised controlled trial. LaCeS has demonstrated that it is possible to recruit to a surgical trial in the emergency setting, with good compliance to trial procedures and processes, and overall acceptability by patients and clinicians. The safety data obtained for laparoscopic emergency colorectal surgery indicate an acceptable safety profile, particularly when considering it to that observed in the open arm.Trial Registration ISRCTN15681041 https://doi.org/10.1186/ISRCTN15681041.Funding body: National Institute of Health Research – Research for Patient Benefi

Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

<p>Abstract</p> <p>Background</p> <p><it>Costus speciosus </it>(Koen ex.Retz.) Sm (Costaceae) is an Indian ornamental plant which has long been used medicinally in traditional systems of medicine. The plant has been found to possess diverse pharmacological activities. Rhizomes are used to treat pneumonia, rheumatism, dropsy, urinary diseases, jaundice, skin diseases and leaves are used<b/>to treat mental disorders.</p> <p>Method</p> <p>Antibacterial and antifungal activities were tested using Disc diffusion method and Minimum Inhibitory <b>Concentration </b>(MIC). Column chromatography was used to isolate compounds from hexane extract. X-ray crystallography technique and GC-MS analysis were used to identify the compounds</p> <p>Results</p> <p>Antibacterial and antifungal activities were observed in hexane, chloroform, ethyl acetate and methanol extracts. Hexane extract of <it>C.speciosus </it>showed good activity against tested fungi also. Two sesquiterpenoid compounds were isolated (costunolide and eremanthin) from the hexane extract. Both the compounds did not inhibit the growth of tested bacteria. But, both the compounds inhibited the tested fungi. The compound costunolide showed significant antifungal activity. The MIC values of costunolide were; 62.5 μg/ml against <it>Trichophyton mentagrophytes</it>, 62. μg/ml against <it>T. simii</it>, 31.25 μg/ml against <it>T. rubrum </it>296, 62.5 μg/ml against <it>T. rubrum </it>57, 125 μg/ml against <it>Epidermophyton floccosum</it>, 250 μg/ml against <it>Scopulariopsis </it>sp, 250 μg/ml against <it>Aspergillus niger</it>, 125 μg/ml against <it>Curvulari lunata</it>, 250 μg/ml against <it>Magnaporthe grisea</it>.</p> <p>Conclusion</p> <p>Hexane extract showed promising antibacterial and antifungal activity. The isolated compound costunolide showed good antifungal activity.</p

In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells

BACKGROUND: Lannea schweinfurthii, Zanthoxylum capense, Scadoxus puniceus and Crinum bulbispermum are used traditionally to treat neurological disorders. The aim of this study was to evaluate the cytoprotective potential of the four plants, after induction of toxicity using rotenone, in SH-SY5Y neuroblastoma cells. METHODS: Cytotoxicity of the plant extracts and rotenone was assessed using the sulforhodamine B (SRB) assay. Fluorometry was used to measure intracellular redox state (reactive oxygen species (ROS) and intracellular glutathione content), mitochondrial membrane potential (MMP) and caspase-3 activity, as a marker of apoptotic cell death. RESULTS: Of the tested plants, the methanol extract of Z. capense was the least cytotoxic; LC(50) 121.3 ± 6.97 μg/ml, while S. puniceus methanol extract was the most cytotoxic; LC(50) 20.75 ± 1.47 μg/ml. Rotenone reduced intracellular ROS levels after 24 h exposure. Pre-treating cells with S. puniceus and C. bulbispermum extracts reversed the effects of rotenone on intracellular ROS levels. Rotenone exposure also decreased intracellular glutathione levels, which was counteracted by pre-treatment with any one of the extracts. MMP was reduced by rotenone, which was neutralized by pre-treatment with C. bulbispermum ethyl acetate extract. All extracts inhibited rotenone-induced activation of caspase-3. CONCLUSION: The studied plants demonstrated anti-apoptotic activity and restored intracellular glutathione content following rotenone treatment, suggesting that they may possess neuroprotective properties

Inter-hemispheric asynchrony of the brain during events of apnoea and EEG arousals

Sleep apnoea hypopnea syndrome ( SAHS) is a serious sleep disorder affecting a large percentage of the population. Apnoea/hypopnea and electroencephalographic-arousal ( EEGA) events occur frequently in SAHS patients. These events significantly disturb the sleep architecture, as revealed through nocturnal EEG signals. Even though EEG carries vital information on the state of the brain, its use in clinical SAHS diagnosis is limited mainly to routine sleep staging. In this paper, we address this issue. We propose a novel measure, called the inter-hemispheric asynchrony (psi (a -> b)), to capture EEG-symmetry changes associated with a transition a -> b between the brain states 'a' and 'b'. Our work takes into account macro-states such as the traditional sleep stages, and micro-states such as EEGA and apnoea/hypopnea events. We measured EEG data using electrodes C4-A2 and C3-A1 of the International 10/20 System from 18 subjects undergoing polysomnography ( PSG) testing. These electrode pairs are symmetrical about the brain mid-line and allow us to discern any hemispheric EEG asymmetry. EEG data were segmented and filtered into classical bands delta( 0.5-4 Hz), theta( 4.1-8 Hz), alpha( 8.1-12 Hz) and beta( 12.1-16 Hz). Then they were further categorized according to the particular sleep state of their origin. Spectral correlation coefficients were computed between the EEG data from the two hemispheres and averaged over the overnight EEG recording. This was done for each frequency band and state of interest, and then the measure psi(a -> b) was computed. Results from the 18 subjects showed that psi(a -> b) increased significantly ( p b) changes significantly ( p b) provides a novel insight into the functional asymmetry of the brain during SAHS events