Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins

Planar polarity refers to cellular polarity in an orthogonal plane to apicobasal polarity, and is seen across scales from molecular distributions of proteins to tissue patterning. In many contexts it is regulated by the evolutionarily conserved ‘core' planar polarity pathway that is essential for normal organismal development. Core planar polarity pathway components form asymmetric intercellular complexes that communicate polarity between neighbouring cells and direct polarised cell behaviours and the formation of polarised structures. The core planar polarity pathway consists of six structurally different proteins. In the fruitfly Drosophila melanogaster, where the pathway is best characterised, an intercellular homodimer of the seven-pass transmembrane protein Flamingo interacts on one side of the cell junction with the seven-pass transmembrane protein Frizzled, and on the other side with the four-pass transmembrane protein Strabismus. The cytoplasmic proteins Diego and Dishevelled are co-localised with Frizzled, and Prickle co-localises with Strabismus. Between these six components there are myriad possible molecular interactions, which could stabilise or destabilise the intercellular complexes and lead to their sorting into polarised distributions within cells. Post-translational modifications are key regulators of molecular interactions between proteins. Several post-translational modifications of core proteins have been reported to be of functional significance, in particular phosphorylation and ubiquitination. In this review, we discuss the molecular control of planar polarity and the molecular ecology of the core planar polarity intercellular complexes. Furthermore, we highlight the importance of understanding the spatial control of post-translational modifications in the establishment of planar polarity

Limitations of the Digestible Indispensable Amino Acid Score (DIAAS) and choice of statistical reporting. Comment on “A comparison of dietary protein digestibility, based on DIAAS scoring, in vegetarian and non-vegetarian athletes. Nutrients 2019, 11, 3106”

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Fashion micro-enterprises in London, Berlin, Milan

This report provides an account of a series of interviews, observational visits and hosted events with 8-10 fashion designers in three cities: London, Berlin and Milan, carried out from 2012-2016. In some cases we interviewed the same designers two or three times over a period of nearly three years. The research project also entailed documented conversations and meetings with a range of fashion experts, consultants, legal advisors and policy makers in each city. Often these took place within the context of organised events undertaken as part of the research process. The aim was to investigate the kind of start-ups or micro-enterprises which have come into being in the last decade. We were interested in whether these were the outcome of pro-active urban creative economy policies or if they were self-organised initiatives, a reaction to the crisis of the euro-zone of 2008 and the consequent recession. Was it the case that long-term austerity policies and exceptionally high rates of youth and graduate unemployment across Europe had spawned these kinds of seemingly independent economic activities? We were also minded to consider the role of intellectual property (IP) and copyright in fashion as part of the wider UK government agenda for growth and wealth creation within the creative economy as a whole

The impact of self-reported hearing difficulties on memory collaboration in older adults

Cognitive scientists and philosophers recently have highlighted the value of thinking about people at risk of or living with dementia as intertwined parts of broader cognitive systems that involve their spouse, family, friends, or carers. By this view, we rely on people and things around us to “scaffold” mental processes such as memory. In the current study, we identified 39 long-married, older adult couples who are part of the Australian Imaging Biomarkers and Lifestyle (AIBL) Study of Ageing; all were cognitively healthy but half were subjective memory complainers. During two visits to their homes 1 week apart, we assessed husbands’ and wives’ cognitive performance across a range of everyday memory tasks working alone (Week 1) versus together (Week 2), including a Friends Task where they provided first and last names of their friends and acquaintances. As reported elsewhere, elderly couples recalled many more friends’ names working together compared to alone. Couples who remembered successfully together used well-developed, rich, sensitive, and dynamic communication strategies to boost each other’s recall. However, if one or both spouses self-reported mild-to-moderate or severe hearing difficulties (56% of husbands, 31% of wives), couples received less benefit from collaboration. Our findings imply that hearing loss may disrupt collaborative support structures that couples (and other intimate communicative partners) hone over decades together. We discuss the possibility that, cut off from the social world that scaffolds them, hearing loss may place older adults at greater risk of cognitive decline and dementia

The Mersey Estuary : sediment geochemistry

This report describes a study of the geochemistry of the Mersey estuary carried out between April 2000 and December 2002. The study was the first in a new programme of surveys of the geochemistry of major British estuaries aimed at enhancing our knowledge and understanding of the distribution of contaminants in estuarine sediments. The report first summarises the physical setting, historical development, geology, hydrography and bathymetry of the Mersey estuary and its catchment. Details of the sampling and analytical programmes are then given followed by a discussion of the sedimentology and geochemistry. The chemistry of the water column and suspended particulate matter have not been studied, the chief concern being with the geochemistry of the surface and near-surface sediments of the Mersey estuary and an examination of their likely sources and present state of contamination

Accelerator measurements of magnetically-induced radio emission from particle cascades with applications to cosmic-ray air showers

For fifty years, cosmic-ray air showers have been detected by their radio emission. We present the first laboratory measurements that validate electrodynamics simulations used in air shower modeling. An experiment at SLAC provides a beam test of radio-frequency (RF) radiation from charged particle cascades in the presence of a magnetic field, a model system of a cosmic-ray air shower. This experiment provides a suite of controlled laboratory measurements to compare to particle-level simulations of RF emission, which are relied upon in ultra-high-energy cosmic-ray air shower detection. We compare simulations to data for intensity, linearity with magnetic field, angular distribution, polarization, and spectral content. In particular, we confirm modern predictions that the magnetically induced emission in a dielectric forms a cone that peaks at the Cherenkov angle and show that the simulations reproduce the data within systematic uncertainties.Comment: 5 pages, 7 figure

Configuration Management for Distributed Software Services

The paper describes the SysMan approach to interactive configuration management of distributed software components (objects). Domains are used to group objects to apply policy and for convenient naming of objects. Configuration Management involves using a domain browser to locate relevant objects within the domain service; creating new objects which form a distributed service; allocating these objects to physical nodes in the system and binding the interfaces of the objects to each other and to existing services. Dynamic reconfiguration of the objects forming a service can be accomplished using this tool. Authorisation policies specify which domains are accessible by which managers and which interfaces can be bound together. Keywords Domains, object creation, object binding, object allocation, graphical management interface. 1 INTRODUCTION The object-oriented approach brings considerable benefits to the design and implementation of software for distributed systems (Kramer 1992). Con..

Growth in densely populated Asia: implications for primary product exporters

Economic growth and integration in Asia is rapidly increasing the global economic importance of the region. To the extent that this growth continues and is strongest in natural resource-poor Asian economies, it will add to global demand for imports of primary products, to the benefit of (especially nearby) resource-abundant countries. How will global production, consumption and trade patterns change by 2030 in the course of such economic developments and structural changes? We address this question using the GTAP model and Version 8.1 of the 2007 GTAP database, together with supplementary data from a range of sources, to support projections of the global economy from 2007 to 2030 under various scenarios. Factor endowments and real gross domestic product are assumed to grow at exogenous rates, and trade-related policies are kept unchanged to generate a core baseline, which is compared with an alternative slower growth scenario. We also consider the impact of several policy changes aimed at increasing China's agricultural self-sufficiency relative to the 2030 baseline. Policy implications for countries of the Asia-Pacific region are drawn out in the final section

A Maturity Model for IT Dependability in Emergency Management

In many organisations a gap exists between IT management and emergency managemement. This paper illustrates how process improvement based on a maturity model can be used to help organisations to evaluate and improve the way they include IT dependability information in their emergency management. This paper presents the IDEM3 (IT Dependability in Emergency Management Maturity Model) process improvement framework which focuses especially on the cooperation between IT personnel, emergency managers, and users, to proactively prevent IT dependability problems when the IT systems are most critical in emergency situations. This paper describes the details of the framework, how the framework was developed and its relation to other maturity models in related fields

Gaussian random waves in elastic media

Similar to the Berry conjecture of quantum chaos we consider elastic analogue which incorporates longitudinal and transverse elastic displacements with corresponding wave vectors. Based on that we derive the correlation functions for amplitudes and intensities of elastic displacements. Comparison to numerics in a quarter Bunimovich stadium demonstrates excellent agreement.Comment: 4 pages, 4 figure