Phonetic Imitation from an Individual-Difference Perspective: Subjective Attitude, Personality and “Autistic” Traits

Numerous studies have documented the phenomenon of phonetic imitation: the process by which the production patterns of an individual become more similar on some phonetic or acoustic dimension to those of her interlocutor. Though social factors have been suggested as a motivator for imitation, few studies has established a tight connection between language-external factors and a speaker’s likelihood to imitate. The present study investigated the phenomenon of phonetic imitation using a within-subject design embedded in an individual-differences framework. Participants were administered a phonetic imitation task, which included two speech production tasks separated by a perceptual learning task, and a battery of measures assessing traits associated with Autism-Spectrum Condition, working memory, and personality. To examine the effects of subjective attitude on phonetic imitation, participants were randomly assigned to four experimental conditions, where the perceived sexual orientation of the narrator (homosexual vs. heterosexual) and the outcome (positive vs. negative) of the story depicted in the exposure materials differed. The extent of phonetic imitation by an individual is significantly modulated by the story outcome, as well as by the participant’s subjective attitude toward the model talker, the participant’s personality trait of openness and the autistic-like trait associated with attention switching.</p

Assessing the conversion of electronic medical record data into antibiotic stewardship indicators.

BACKGROUND Measuring the appropriateness of antibiotic use is crucial for antibiotic stewardship (ABS) programmes to identify targets for interventions. OBJECTIVES To assess the technical feasibility of converting electronic medical record (EMR) data into ABS indicators. METHODS In this observational feasibility study covering a period of 2 years, the EMRs of patients hospitalized at a large non-university hospital network and receiving at least one dose of a systemic antibiotic were included. ABS indicators measuring steps in the process of antibiotic prescription proposed by the literature were collected and rephrased or defined more specifically to be calculable if needed. Algorithms were programmed in R to convert EMR data into ABS indicators. The indicators were visualized in an interactive dashboard and the plausibility of each output value was assessed. RESULTS In total, data from 25 337 hospitalizations from 20 723 individual patients were analysed and visualized in an interactive dashboard. Algorithms could be programmed to compute 89% (25/28) of all pre-selected indicators assessing treatment decisions automatically out of EMR data, with good data quality for 46% (13/28) of these indicators. According to the data quality observed, the most important issues were (i) missing or meaningless information on indication (e.g. 'mild infection') and (ii) data processing issues such as insufficiently categorized metadata. CONCLUSIONS The calculation of indicators assessing treatment decisions from EMRs was feasible. However, better data structure and processing within EMR systems are crucial for improving the validity of the results

Behaviour of adenylic and pyridinic compounds in gingival tissue after a short-term exposure to air

Biochemical variations of adenine and pyridine compounds in human gingival grafts during the period between excision and implantation have been studied. These groups of compounds are considered as «indicators» of the metabolic and energetic status of the living cells. Adenylic compounds such as ATP, ADP and AMP are involved in numerous metabolic processes as «modulators» of allosteric enzymes.NAD+ and NADP+ are involved in the carbohydrate metabolism as co-factors of many reactions of oxydoreduction. The exposure to air of the gingival tissue induces modifications in the energy state of the cells as well as in the ox-reox system. No variation is detectable in the intermediates of the pyridine compounds cycle.Dans des gencives humaines prélevées pour des greffes, ont été étudiées, à certains intervalles de temps entre le prélèvement et la greffe, les variations biochimiques des composés adényliques et pyridiniques, qui sont les «indicateurs» des conditions énergétiques et métaboliques du tissu. Des composés comme l’ATP, l’ADP et l’AMP participent à de nombreux processus métaboliques comme «modulateurs» des enzymes allostériques. NAD+ et NADP + participent au métabolisme des carbohydrates comme co-facteurs de nombreuses réactions d’oxydoréduction. Une brève exposition de la gencive à l’air provoque des changements dans le métabolisme des cellules et du système d’oxydoréduction. Il n’y a pas de variation notable dans les composés intermédiaires du cycle pyridinique

The axonally secreted protein axonin-1 is a potent substratum for neurite growth

Axonin-1 is a neuronal glycoprotein occurring both as a membrane-bound and a secreted form. Membrane-bound axonin-1 is predominantly located in membranes of developing nerve fiber tracts and has recently been characterized as a cell adhesion molecule; the soluble form is secreted from axons and accumulates in the cerebrospinal fluid and the vitreous fluid of the eye. In the present study, we addressed the question as to whether secreted axonin-1 was released in a functionally competent form and we found that it strongly promotes neurite outgrowth when presented to neurons as an immobilized substratum. Neurite lengths elaborated by embryonic dorsal root ganglia neurons on axonin-1 were similar to those on the established neurite-promoting substrata L1 and laminin. Fab fragments of axonin-1 antibodies completely inhibited neurite growth on axonin-1, but not on other substrata. In soluble form, axonin-1 had an anti-adhesive effect, as revealed by perturbation of neurite fasciculation. In view of their structural similarity, we conclude that secreted and membrane-bound axonin-1 interact with the same growth-promoting neuritic receptor. The fact that secreted axonin-1 is functionally active, together with our previous findings that it is secreted from an internal cellular pool, suggests a functional dualism between membrane-bound and secreted axonin-1 at the site of secretion, which is most likely the growth cone. The secretion of adhesion molecules could represent a powerful and rapidly acting regulatory element of growth cone-neurite interactions in the control of neurite elongation, pathway selection, and possibly target recognition

Predicting users' first impressions of website aesthetics with a quantification of perceived visual complexity and colorfulness

Users make lasting judgments about a website's appeal within a split second of seeing it for the first time. This first impression is influential enough to later affect their opinions of a site's usability and trustworthiness. In this paper, we demonstrate a means to predict the initial impression of aesthetics based on perceptual models of a website's colorfulness and visual complexity. In an online study, we collected ratings of colorfulness, visual complexity, and visual appeal of a set of 450 websites from 548 volunteers. Based on these data, we developed computational models that accurately measure the perceived visual complexity and colorfulness of website screenshots. In combination with demographic variables such as a user's education level and age, these models explain approximately half of the variance in the ratings of aesthetic appeal given after viewing a website for 500ms only.Engineering and Applied Science

The Envelope Thermal Test Unit (ETTU): Full Measurement of WallPerform ance

There are many ways of calculating the dynamic thermal performance of walls and many ways of measuring the performance of walls in the laboratory, relatively few field measurements have been made of the dynamic performance of wall in situ. Measuring the thermal performance of walls in situ poses two separate problems: measuring the heat fluxes and surface temperatures of the wall, and reducing this data set into usable parameters. We have solved the first problem by developing the Envelope Thermal Test Unit (ETTU). ETTU consists of two specially constructed polystyrene blankets, 1.2m square, placed on either side of the test wall that both control and measure the surface fluxes and surface temperatures of the wall. To solve the second problem we have developed a simplified dynamic model that describes the thermal performance of a wall in terms of its steady-state conductance, a time constant, and some storage terms. We have used ETTU in the field to measure the thermal performance of walls, and have applied our simplified analysis to calculate simplified thermal parameters from this data set. In this report, we present the in-situ measurements made to date using ETTU, and the resulting model predictions. The agreement between measured and predicted surface fluxes demonstrates the ability of our test unit and analytic model to describe the dynamic performance of walls in situ

Biosynthesis of Mitochondrial Porin and Insertion into the Outer Mitochondrial Membrane of Neuruspora crassa

Mitochondrial porin, the major protein of the outer mitochondrial membrane is synthesized by free cytoplasmic polysomes. The apparent molecular weight of the porin synthesized in homologous or heterologous cell-free systems is the same as that of the mature porin. Transfer in vitro of mitochondrial porin from the cytosolic fraction into the outer membrane of mitochondria could be demonstrated. Before membrane insertion, mitochondrial porin is highly sensitive to added proteinase; afterwards it is strongly protected. Binding of the precursor form to mitochondria occurs at 4°C and appears to precede insertion into the membrane. Unlike transfer of many precursor proteins into or across the inner mitochondrial membrane, assembly of the porin is not dependent on an electrical potential across the inner membrane

Baryonic Effect on chi_cJ Suppression in Au+Au Collisions at RHIC Energies

We predict that initially produced chi_cJ mesons at low transverse momentum in the central rapidity region are almost dissociated by nucleons and antinucleons in hadronic matter produced in central Au+Au collisions at RHIC energies sqrt {s_{NN}}= 130 and 200 GeV. In calculations the nucleon and antinucleon distributions in hadronic matter are results of evolution from their freeze-out distributions which well fit the experimental p_T spectra of proton and antiproton. Any measured chi_cJ mesons at low p_T are generated from deconfined matter and give an explicit proof of regeneration mechanism (recombination mechanism).Comment: 10 pages, 3 figures, Latex, a discussion added to the referenc