Diversity, relationships and conservation of Sicilian wild taxa of Brassica: an overview

Although lots of studies have been carried out through various analytical approaches and at different taxonomic levels, this overview reveals that actually a comprehensive biosystematic survey on the Mediterranean wild populations of Brassica oleracea group is still lacking

Inulin for Cancer Therapy: Present and Perspectives

Inulin is an extremely adaptable polysaccharides consisting of glucopyranose end-capped (\u3b2-1,2) fructose repeating units and, as it is, can be classified as an inherently multifunctional polymeric scaffold. It may be further functionalized employing mild conditions to give rise desired biological and physicochemical properties exploitable for targeted anticancer applications (e.g., active targeting toward specific cytotypes, self-assembling behavior, selective cytoxicity and hyperthermia features). In this review, the main chemical features and the inulin derivatives applications in the field of targeted anticancer therapy is reported and discusse

LA COLLEZIONE DI FAGIOLI DELLA BANCA VIVENTE DEL GERMOPLASMA VEGETALE DEI NEBRODI (UCRIA, MESSINA)

Nell\u2019ambito delle attivit\ue0 di promozione della conservazione della biodiversit\ue0 vegetale in Sicilia, l\u2019Orto Botanico di Palermo ha sviluppato una serie di progetti, alcuni dei quali in collaborazione con gli enti gestori di aree protette. Fra di essi rientra la realizzazione di una banca vivente del germoplasma vegetale, organizzata ad Ucria, in provincia di Messina, in collaborazione con il Parco regionale dei Nebrodi. Oltre a una considerevole collezione di fruttiferi anticamente coltivati e reperiti nelle campagne siciliane, il patrimonio di agrobiodiversit\ue0 della Banca, comprende variet\ue0 di piante ortive tra cui emerge la collezione di fagioli, risultato di una attenta esplorazione del territorio. Obbiettivo di questa specifica raccolta \ue8 stato quello di valorizzare il patrimonio agro-alimentare delle comunit\ue0 locali, mediante il recupero di cultivar autoctone o in via di estinzione

Folic acid-functionalized graphene oxide nanosheets via plasma etching as a platform to combine NIR anticancer phototherapy and targeted drug delivery

PEGylated graphene oxide (GO) has shown potential as NIR converting agent to produce local heat useful in breast cancer therapy, since its suitable photothermal conversion, high stability in physiological fluids, biocompatibility and huge specific surface. GO is an appealing nanomaterial for potential clinical applications combining drug delivery and photothermal therapy in a single nano-device capable of specifically targeting breast cancer cells. However, native GO sheets have large dimensions (0.5-5 mu m) such that tumor accumulation after a systemic administration is usually precluded. Herein, we report a step-by-step synthesis of folic acid-functionalized PEGylated GO, henceforth named GO-PEG-Fol, with small size and narrow size distribution (similar to 30 +/- 5 nm), and the ability of efficiently converting NIR light into heat. GO-PEG-Fol consists of a nano-GO sheet, obtained by fragmentation of GO by means of non-equilibrium plasma etching, fully functionalized with folic acid-terminated PEG(2000) chains through amidic coupling and azide-alkyne click cycloaddition, which we showed as active targeting agents to selectively recognize breast cancer cells such as MCF7 and MDA-MB-231. The GO-PEG-Fol incorporated a high amount of doxorubicin hydrochloride (Doxo) (> 33%) and behaves as NIR-light-activated heater capable of triggering sudden Doxo delivery inside cancer cells and localized hyperthermia, thus provoking efficient breast cancer death. The cytotoxic effect was found to be selective for breast cancer cells, being the IC50 up to 12 times lower than that observed for healthy fibroblasts. This work established plasma etching as a cost-effective strategy to get functionalized nano-GO with a smart combination of properties such as small size, good photothermal efficiency and targeted cytotoxic effect, which make it a promising candidate as photothermal agent for the treatment of breast cancer

Plant Conservation Centres in Sicily: The ‘Valle Maria’ Regional Centre (Godrano, Palermo) and the case study of the rare Centaurea erycina (Asteraceae).

The role of the ‘Valle Maria’ Regional Centre and its activity in plant conservation thank to the collaboration with the University of Palermo, Dept. STEBICEF is discussed. The case study on propagation of Centaurea erycina, a narrow Sicilian endemic is presented

Modified montmorillonite as drug delivery agent for enhancing antibiotic therapy

The appealing properties of surfactant‐intercalated Montmorillonites (Organo-montmorillonite, OMt) were successfully investigated to propose an effective drug delivery system for metronidazole (MNE) antibiotic therapy. This represents a serious pharmaceutical concern due to the adverse drug reactions and the low targeting ability of MNE. The non‐ionic surfactant Tween 20 was used to functionalize montmorillonite, thus accomplishing the two‐fold objective of enhancing the stability of clay dispersion and better controlling drug uptake and release. The adsorption process was performed under different experimental conditions and investigated by constructing the adsorption isotherms through high‐performance liquid chromatography (HPLC) measurements. Powder X‐ray diffraction (XRD) measurements were performed to characterize the MNE/OMt compounds. The gathered results revealed that the uptake of the drug occurs preferentially in the clay interlayer, and it is governed by positive cooperative processes. The presence of surfactant drives the adsorption into clay interlayer and hampers the adsorption onto external lamella faces. The good performances of the prepared OMt in the controlled release of the MNE were proved by investigating the release profiles under physiological conditions, simulating oral drug administration. Cytotoxicity measurements demonstrated the biocompatibility of the complexes and evidenced that, under specific experimental conditions, nanodevices are more biocompatible than a free drug

Factors Affecting Consumers’ Purchase Intention of Eco-friendly Food in China: The Evidence from Respondents in Beijing

The purpose aims to examine the key factors influencing Chinese consumer’s purchasing behaviour of eco-friendly food in China giving its context as an emerging economy and its rapidly rising importance in the world eco-friendly food market. This paper adopts and extends the Responsible Environmental Behaviour (REB) theory by empirically testing key psycho-social factors influencing the purchase intention of eco-friendly food and the moderating effects of consumers’ demographic characteristics on the relationship between the key psycho-social factors and the purchase intention.  A number of hypotheses are proposed. A questionnaire was designed and distributed via online survey in Beijing, China.  A total of 239 valid responses were received. The empirical data was used to test the research hypotheses using the hierarchical multiple regression analysis. The research finds that the personality factors in the REB model (i.e., pro-environmental attitudes, the internal locus of control and personal responsibly) have significant positive effects on the consumers’ eco-friendly food purchase intention. Such effect is stable across consumers with different income levels. On the other hand, the knowledge-skill factors in the REB model do not have significant effect on the purchase intention of consumers. This study contributes to a better understanding of factors affecting eco-friendly food consumption intention in China and the behavioural characteristics of consumers in developing countries. Moreover, the findings also shed light on the applicability of the REB theory in emerging economies and a specific industrial context

Antibody response elicited by the SARS-CoV-2 vaccine booster in patients with multiple sclerosis: Who gains from it?

Background and purpose: Although two doses of COVID-19 vaccine elicited a protective humoral response in most persons with multiple sclerosis (pwMS), a significant group of them treated with immunosuppressive disease-modifying therapies (DMTs) showed less efficient responses. Methods: This prospective multicenter observational study evaluates differences in immune response after a third vaccine dose in pwMS. Results: Four hundred seventy-three pwMS were analyzed. Compared to untreated patients, there was a 50-fold decrease (95% confidence interval [CI] = 14.3–100.0, p < 0.001) in serum SARS-CoV-2 antibody levels in those on rituximab, a 20-fold decrease (95% CI = 8.3–50.0, p < 0.001) in those on ocrelizumab, and a 2.3-fold decrease (95% CI = 1.2–4.6, p = 0.015) in those on fingolimod. As compared to the antibody levels after the second vaccine dose, patients on the anti-CD20 drugs rituximab and ocrelizumab showed a 2.3-fold lower gain (95% CI = 1.4–3.8, p = 0.001), whereas those on fingolimod showed a 1.7-fold higher gain (95% CI = 1.1–2.7, p = 0.012), compared to patients treated with other DMTs. Conclusions: All pwMS increased their serum SARS-CoV-2 antibody levels after the third vaccine dose. The mean antibody values of patients treated with ocrelizumab/rituximab remained well below the empirical "protective threshold" for risk of infection identified in the CovaXiMS study (>659 binding antibody units/mL), whereas for patients treated with fingolimod this value was significantly closer to the cutoff

iCollections – Digitising the British and Irish Butterflies in the Natural History Museum, London

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.NHM Repositor