59 research outputs found
Optical detection of spin transport in non-magnetic metals
We determine the dynamic magnetization induced in non-magnetic metal wedges
composed of silver, copper and platinum by means of Brillouin light scattering
(BLS) microscopy. The magnetization is transferred from a ferromagnetic
Ni80Fe20 layer to the metal wedge via the spin pumping effect. The spin pumping
efficiency can be controlled by adding an insulating but transparent interlayer
between the magnetic and non-magnetic layer. By comparing the experimental
results to a dynamical macroscopic spin-transport model we determine the
transverse relaxation time of the pumped spin current which is much smaller
than the longitudinal relaxation time
Continuous venovenous hemodiafiltration with a low citrate dose regional anticoagulation protocol and a phosphate-containing solution: effects on acid–base status and phosphate supplementation needs
BACKGROUND:
Recent guidelines suggest the adoption of regional citrate anticoagulation (RCA) as first choice CRRT anticoagulation modality in patients without contraindications for citrate. Regardless of the anticoagulation protocol, hypophosphatemia represents a potential drawback of CRRT which could be prevented by the adoption of phosphate-containing CRRT solutions. The aim was to evaluate the effects on acid--base status and phosphate supplementation needs of a new RCA protocol for Continuous Venovenous Hemodiafiltration (CVVHDF) combining the use of citrate with a phosphate-containing CRRT solution.
METHODS:
To refine our routine RCA-CVVH protocol (12 mmol/l citrate, HCO3- 32 mmol/l replacement fluid) (protocol A) and to prevent CRRT-related hypophosphatemia, we introduced a new RCA-CVVHDF protocol (protocol B) combining an 18 mmol/l citrate solution with a phosphate-containing dialysate/replacement fluid (HCO3- 30 mmol/l, Phosphate 1.2). A low citrate dose (2.5--3 mmol/l) and a higher than usual target circuit-Ca2+ (<=0.5 mmol/l) have been adopted.
RESULTS:
Two historical groups of heart surgery patients (n = 40) underwent RCA-CRRT with protocol A (n = 20, 102 circuits, total running time 5283 hours) or protocol B (n = 20, 138 circuits, total running time 7308 hours). Despite higher circuit-Ca2+ in protocol B (0.37 vs 0.42 mmol/l, p < 0.001), circuit life was comparable (51.8 +/- 36.5 vs 53 +/- 32.6 hours). Protocol A required additional bicarbonate supplementation (6 +/- 6.4 mmol/h) in 90% of patients while protocol B ensured appropriate acid--base balance without additional interventions: pH 7.43 (7.40--7.46), Bicarbonate 25.3 (23.8--26.6) mmol/l, BE 0.9 (-0.8 to +2.4); median (IQR). No episodes of clinically relevant metabolic alkalosis, requiring modifications of RCA-CRRT settings, were observed. Phosphate supplementation was needed in all group A patients (3.4 +/- 2.4 g/day) and in only 30% of group B patients (0.5 +/- 1.5 g/day). Hypophosphatemia developed in 75% and 30% of group A and group B patients, respectively. Serum phosphate was significantly higher in protocol B patients (P < 0.001) and, differently to protocol A, appeared to be steadily maintained in near normal range (0.97--1.45 mmol/l, IQR)
Next Generation Sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease. Schultheiss et al
Supplemental Information for Schultheiss et al 2020, Immunity; DOI:https://doi.org/10.1016/j.immuni.2020.06.024THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Studien- und Rekrutierungs-Update: frühe Reperfusion mit intravenöser Alteplase beim nicht-arteriitischen Zentralarterienverschluss der Netzhaut (REVISION-Studie)
Studien- und Rekrutierungs-Update: frühe Reperfusion mit intravenöser Alteplase beim nicht-arteriitischen Zentralarterienverschluss der Netzhaut (REVISION) - eine doppelt-blinde randomisierte placebokontrollierte Studie
Motivation und Persönlichkeit: Von der Analyse von Teilsystemen zur Analyse ihrer Interaktion
Brunstein JC, Maier GW, Schultheiß OC. Motivation und Persönlichkeit: Von der Analyse von Teilsystemen zur Analyse ihrer Interaktion. In: Jerusalem M, Pekrun R, eds. Emotion, Motivation und Leistung. Göttingen: Hogrefe; 1999: 147-167
WNet: A data-driven dual-domain denoising model for sparse-view computed tomography with a trainable reconstruction layer
Deep learning based solutions are being succesfully implemented for a wide
variety of applications. Most notably, clinical use-cases have gained an
increased interest and have been the main driver behind some of the
cutting-edge data-driven algorithms proposed in the last years. For
applications like sparse-view tomographic reconstructions, where the amount of
measurement data is small in order to keep acquisition times short and
radiation dose low, reduction of the streaking artifacts has prompted the
development of data-driven denoising algorithms with the main goal of obtaining
diagnostically viable images with only a subset of a full-scan data. We propose
WNet, a data-driven dual-domain denoising model which contains a trainable
reconstruction layer for sparse-view artifact denoising. Two encoder-decoder
networks perform denoising in both sinogram- and reconstruction-domain
simultaneously, while a third layer implementing the Filtered Backprojection
algorithm is sandwiched between the first two and takes care of the
reconstruction operation. We investigate the performance of the network on
sparse-view chest CT scans, and we highlight the added benefit of having a
trainable reconstruction layer over the more conventional fixed ones. We train
and test our network on two clinically relevant datasets and we compare the
obtained results with three different types of sparse-view CT denoising and
reconstruction algorithms.Comment: First submitted to IEEE TIP in December 2021. Rejected due to
non-matching scope in April 2022. Currently submitted to IEEE TCI since May
202
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