Two meta-analyses of noncontact healing studies

Reviews of empirical work on the efficacy of noncontact healing have found that interceding on behalf of patients through prayer or by adopting various practices that incorporate an intention to heal can have some positive effect upon their wellbeing. However, reviewers have also raised concerns about study quality and the diversity of healing approaches adopted, which makes the findings difficult to interpret. Some of these concerns can be addressed by adopting a standardised approach based on the double-blind randomised controlled clinical trial, and a recent review restricted to such studies has reported a combined effect size of .40 (p < .001). However, the studies in this review involve human participants for whom there can be no guarantee that control patients are not beneficiaries of healing intentions from friends, family or their own religious groups. We proposed to address this by reviewing healing studies that involved biological systems other than ‘whole’ humans (i.e. to include animal and plant work but also work involving human biological matter such as blood samples or cell cultures), which are less susceptible to placebo and expectancy effects and also allow for more circumscribed outcome measures. Secondly, doubts have been cast concerning the legitimacy of some of the work included in previous reviews so we planned to conduct an updated review that excluded that work. For phase 1, 49 non-whole human studies from 34 papers were eligible for review. The combined effect size weighted by sample size yielded a highly significant r of .258. However the effect sizes in the database were heterogeneous, and outcomes correlated with blind ratings of study quality. When restricted to studies that met minimum quality thresholds, the remaining 22 studies gave a reduced but still significant weighted r of .115. For phase 2, 57 whole human studies across 56 papers were eligible for review. When combined, these studies yielded a small effect size of r = .203 that was also significant. This database was also heterogeneous, and outcomes were correlated with methodological quality ratings. However, when restricted to studies that met threshold quality levels the weighted effect size for the 27 surviving studies increased to r = .224. Taken together these results suggest that subjects in the active condition exhibit a significant improvement in wellbeing relative to control subjects under circumstances that do not seem to be susceptible to placebo and expectancy effects. Findings with the whole human database gave a smaller mean effect size but this was still significant and suggests that the effect is not dependent upon the previous inclusion of suspect studies and is robust enough to accommodate some high profile failures to replicate. Both databases show problems with heterogeneity and with study quality and recommendations are made for necessary standards for future replication attempts

Flow, Liminality, and Eudaimonia: Pagan Ritual Practice as a Gateway to a Life With Meaning

Paganism is a term applied to a number of nature religions based on traditional indigenous practices. Paganism is practiced through rituals designed to facilitate a flow state that allows practitioners to use magic to achieve their aims. Since the introduction of Wicca to mainstream society in the 1950s, many other Pagan traditions have developed. Similarly, the number of people identifying as Pagan has also increased; in 2011, the number of people identifying as Pagan in the U.K. census reached 80,153. Despite this growth, Paganism is a topic that is underresearched in Psychology. This article uses Ryff’s theory of psychological well-being as a frame-work through which to explore the ways in which Paganism may be particularly conducive to eudemonic well-being as a result of the flow experiences inherent in its practice. This theory posits six key dimensions of eudaimonia: personal growth, self-acceptance, positive relation with others, autonomy, environmental mastery, and purpose in life. The ways in which each of these dimensions is elicited through Paganism is elucidated

The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer

Current focus in colorectal cancer management is on reducing overall mortality by increasing the number of early stage cancers diagnosed and treated with curative intent. Despite the success of screening programmes in down-staging colorectal cancer, interval cancer rates are substantial and other strategies are desirable. Sporadic colorectal cancer is largely associated with lifestyle factors including diet. Polyphenols are phytochemicals ingested as part of a normal diet which are abundant in plant foods including fruits/berries and vegetables. These may exert their anti-carcinogenic effects via the modulation of inflammatory pathways. Key signal transduction pathways are fundamental to the association of inflammation and disease progression including those mediated by NF-κB and STAT, PI3K and COX. Our aim was to examine the evidence for the effect of dietary polyphenols intake on tumour and host inflammatory responses to determine if polyphenols may be effective as part of a dietary intervention. There is good epidemiological evidence of a reduction in colorectal cancer risk from case-control and cohort studies assessing polyphenol intake. It would be premature to suggest a major public health intervention to promote their consumption however, dietary change is safe and feasible, emphasising the need for further investigation of polyphenols and colorectal cancer risk

Simulations of core convection in rotating A-type stars: Differential rotation and overshooting

We present the results of 3--D simulations of core convection within A-type stars of 2 solar masses, at a range of rotation rates. We consider the inner 30% by radius of such stars, thereby encompassing the convective core and some of the surrounding radiative envelope. We utilize our anelastic spherical harmonic (ASH) code, which solves the compressible Navier-Stokes equations in the anelastic approximation, to examine highly nonlinear flows that can span multiple scale heights. The cores of these stars are found to rotate differentially, with central cylindrical regions of strikingly slow rotation achieved in our simulations of stars whose convective Rossby number (R_{oc}) is less than unity. Such differential rotation results from the redistribution of angular momentum by the nonlinear convection that strongly senses the overall rotation of the star. Penetrative convective motions extend into the overlying radiative zone, yielding a prolate shape (aligned with the rotation axis) to the central region in which nearly adiabatic stratification is achieved. This is further surrounded by a region of overshooting motions, the extent of which is greater at the equator than at the poles, yielding an overall spherical shape to the domain experiencing at least some convective mixing. We assess the overshooting achieved as the stability of the radiative exterior is varied, and the weak circulations that result in that exterior. The convective plumes serve to excite gravity waves in the radiative envelope, ranging from localized ripples of many scales to some remarkable global resonances.Comment: 48 pages, 16 figures, some color. Accepted to Astrophys. J. Color figures compressed with appreciable loss of quality; a PDF of the paper with better figures is available at http://lcd-www.colorado.edu/~brownim/core_convectsep24.pd

The psychology and phenomenology of spiritualist mental mediumship

Although mediums report a range of experiences that share some similarities with symptom checklists for persons with mental health problems, relatively little systematic research has been undertaken to characterise the mental health and personalities of practising mediums, and none has been conducted in the UK. Previous research in other countries suggests that dissociation, fantasy-proneness and boundary-thinness might distinguish mediums from those who share a similar belief system but do not report mediumistic experiences. To address this, standardised measures were selected and combined in a questionnaire that was distributed to a sample of mediums and non-mediums as part of a nationwide survey. Mediums (N=80) scored significantly higher than non-mediums (N=79) on psychological wellbeing (p <.001), had lower psychological distress (p <.001), higher extraversion (p <.05), higher neuroticism (p <.001), and higher openness to experience (p <.01). No significant differences were found on dissociation, boundary-thinness, fantasy-proneness, conscientiousness or agreeableness. Results suggest that mediumship is not associated with a high level of dissociative experiences or pathology. Findings are discussed in relation to previous research, which proposes that the mediumship role may serve a therapeutic function for both mediums and those who consult them. The survey also included an open-ended Mediumship Activity Questionnaire (MAQ), which was designed to map the range and incidence of mediums' experiences. A content analysis of responses found mediums reported childhood anomalous experiences, family experiences and socialization as contributing factors in the development of their ability. Findings also increased our understanding of the process and nature of mediumship, and the spirit guide phenomenon. However, in order to explore the phenomenology of mediumship, it was clear that an approach would be necessary that could capture the "lived experience" of mediums. Thus, in-depth semi-structured interviews were conducted with ten mediums to explore their understanding of the mediumship process and were analysed using interpretative phenomenological analysis (IPA; Smith, 1996). Six superordinate themes were identified that illuminate key aspects of the mediumship phenomena, such as the various pathways to mediumship and how mediumistic experiences are interpreted and incorporated into a personal experiential framework: "A search for meaning: Normalisation of mediumship", "Progression of mediumship", "Relationship with spirit", "Spirit guides as transcendental", "Explanatory systems of mediumship", and "Mediumship as counselling", One of the main conclusions of this study was that the pathways to mediumship are embedded in a cultural context that provides an important environment in which mediumistic experiences are normalised and validated. Findings are discussed in relation to their clinical implications, in particular the need for mental health professionals to be aware of alternate models and beliefs

The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer

Background: Both preoperative cardiopulmonary exercise test (CPET)-derived measures of fitness and postoperative C-reactive protein (CRP) concentrations are associated with complications following surgery for colorectal cancer. The aim of the present pilot study was to examine the relationship between CPET and postoperative CRP concentrations in this patient group. Methods: Patients who had undergone CPET prior to elective surgery for histologically confirmed colorectal cancer in a single centre between September 2008 and April 2017 were included. Preoperative VO2 at the anaerobic threshold (AT) and peak exercise were recorded, along with preoperative modified Glasgow Prognostic Score (mGPS) and CRP on each postoperative day. Results: Thirty-eight patients were included. The majority were male (30, 79%), over 65 years old (30, 79%), with colonic cancer (23, 61%) and node-negative disease (24, 63%). Fourteen patients (37%) had open surgery and 24 (63%) had a laparoscopic resection. A progressive reduction in VO2 at peak exercise was significantly associated with both increasing American Society of Anesthesiology (ASA) grade (median, ml/kg/min: ASA 1 = 22, ASA 2 = 19, ASA 3 = 15, ASA 4 = 12, p = 0.014) and increasing mGPS (median, ml/kg/min: mGPS 0 = 18, mGPS 1 = 16, mGPS 2 = 14, p = 0.039) There was no significant association between either VO2 at the AT or peak exercise and postoperative CRP. Conclusions: The present pilot study reports a possible association between preoperative CPET-derived measures of exercise tolerance, and the preoperative systemic inflammatory response, but not postoperative CRP in patients undergoing surgery for colorectal cancer

The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer

Background: The magnitude of the postoperative systemic inflammatory response (SIR), as evidenced by C-reactive protein (CRP), is associated with both short- and long-term outcomes following surgery for colorectal cancer. The present study examined the impact of preoperative dexamethasone on the postoperative SIR and complications following elective surgery for colorectal cancer. Methods: Patients who underwent elective surgery, with curative intent, for colorectal cancer at a single center between 2008 and 2016 were included (n = 556) in this study. Data on the use of preoperative dexamethasone were obtained from anesthetic records, and its impact on CRP on postoperative days (PODs) 3 and 4, as well as postoperative complications, was assessed using propensity score matching (n = 276). Results: In the propensity score-matched cohort, preoperative dexamethasone was associated with fewer patients exceeding the established CRP threshold of 150 mg/L on POD 3 (odds ratio [OR] 0.42, 95% confidence interval [CI] 0.26–0.70, p &#60; 0.001) and fewer postoperative complications (OR 0.53, 95% CI 0.33–0.86, p = 0.009). Similar results for both POD 3 CRP and complications were observed when using propensity score-adjusted regression (OR 0.40, 95% CI 0.28–0.57 and OR 0.57, 95% CI 0.41–0.80, respectively) and propensity score stratification (OR 0.41, 95% CI 0.25–0.57 and OR 0.53, 95% CI 0.33–0.86, respectively). Conclusions: Preoperative dexamethasone was associated with a lower postoperative SIR and fewer complications following elective surgery for colorectal cancer

Exploring the meaning in meaningful coincidences: an interpretative phenomenological analysis of synchronicity in therapy

Synchronicity experiences (SEs) are defined as psychologically meaningful connections between inner events (e.g., thought, dream or vision) and one or more external events occurring simultaneously or at a future point in time. There has been limited systematic research that has investigated the phenomenology of SEs in therapy. This study aimed to redress this by exploring the process and nature of such experiences from the perspective of the practitioner. Interpretative phenomenological analysis (IPA; Smith, Flowers, & Larkin, 2009) was used to interview a purposive sample of nine practitioners who reported SEs in their therapeutic sessions. Semi-structured face-to-face interviews were conducted with three counsellors, three psychologists and three psychotherapists, and focused on how participants make sense of their experiences of synchronicity in therapy. Three superordinate themes were identified: Sense of connectedness, therapeutic process, and professional issues. Findings suggest that SEs can serve to strengthen the therapeutic relationship and are perceived as useful harbingers of information about the therapeutic process, as well as being a means of overcoming communication difficulties, as they are seen to provide insights into the client’s experiencing of themselves and others, regardless of whether or not the SE is acknowledged by the client or disclosed by the therapist

In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study"

No abstract available