Unordered Canonical Ramsey Numbers

AbstractWe define a weak form of canonical colouring, based on that of P. Erdős and R. Rado (1950, J. London Math. Soc.25, 249–255). This yields a class of unordered canonical Ramsey numbers CR(s, t), again related to the canonical Ramsey numbers ER(2; s) of Erdős and Rado. We present upper and lower bounds (the latter via a construction) for CR(s, t) which are significantly tighter than the best-known corresponding bounds for ER(2; s)

Cell synchronization and dynamic G-banding of equine chromosomes by bromodeoxyurldine

Both dynamic G-banding and cell synchronization produced by bromodeoxyuridine (BrdU), were applied to equine chromosomes. BrdU incorporated during the first half of the S-phase is taken up into the R-bands that are early replicating. These bands, which have incorporated BrdU, cannot contract as usual and remain elongated; only the other regions of the chromosome, i.e., the G-bands, contract normally and are sharply defined. BrdU also can be used for cell synchronization. The addition of BrdU in a high concentration, 15 hours before harvest, and its removal 11 hours later, has two effects: initially the BrdU is incorporated during the first part of the S-phase and then it blocks the cells at mid-S-phase. Within the cell cycle, mid-S-phase appears to be the most vuinerable time to various blocking agents. To differentiate the regions of BrdU incorporation from those that have not been substituted, the fluorescence-photolysis-Glemsa (FPG) technique was applied as modified for horse chromosomes. This dynamic technique, which produces many prometaphase and prophase chromosomes showing very sharp G-bands, is certain to enhance the accuracy of cytogenetic analysis and aid in the standardization of equine chromosome

Phase transitions in a gas of anyons

We continue our numerical Monte Carlo simulation of a gas of closed loops on a 3 dimensional lattice, however now in the presence of a topological term added to the action corresponding to the total linking number between the loops. We compute the linking number using certain notions from knot theory. Adding the topological term converts the particles into anyons. Using the correspondence that the model is an effective theory that describes the 2+1-dimensional Abelian Higgs model in the asymptotic strong coupling regime, the topological linking number simply corresponds to the addition to the action of the Chern-Simons term. We find the following new results. The system continues to exhibit a phase transition as a function of the anyon mass as it becomes small \cite{mnp}, although the phases do not change the manifestation of the symmetry. The Chern-Simons term has no effect on the Wilson loop, but it does affect the {\rm '}t Hooft loop. For a given configuration it adds the linking number of the 't Hooft loop with all of the dynamical vortex loops to the action. We find that both the Wilson loop and the 't Hooft loop exhibit a perimeter law even though there are no massless particles in the theory, which is unexpected.Comment: 6 pages, 5 figure

Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).

BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule. We demonstrate the effectiveness of this schedule in a noncontrolled, multinational drug-utilization study. METHODS: A total of 2020 patients with late-stage HAT were treated with the 10-day melarsoprol schedule in 16 centers in 7 African countries. We assessed outcome on the basis of major adverse events and the cure rate after treatment and during 2 years of follow-up. RESULTS: The cure rate 24 h after treatment was 93.9%; 2 years later, it was 86.2%. However, 49.3% of patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular eruptions was 0.8% and 6.8%, respectively. CONCLUSIONS: The 10-day treatment schedule was well implemented in the field and was effective. It reduces treatment duration, drug amount, and hospitalization costs per patient, and it increases treatment-center capacity. The shorter protocol has been recommended by the International Scientific Council for Trypanosomiasis Research and Control for the treatment of late-stage HAT caused by Trypanosoma brucei gambiense

Deep near-IR observations of the Globular Cluster M4: Hunting for Brown Dwarfs

We present an analysis of deep HST/WFC3 near-IR (NIR) imaging data of the globular cluster M4. The best-photometry NIR colour-magnitude diagram (CMD) clearly shows the main sequence extending towards the expected end of the Hydrogen-burning limit and going beyond this point towards fainter sources. The white dwarf sequence can be identified. As such, this is the deepest NIR CMD of a globular cluster to date. Archival HST optical data were used for proper-motion cleaning of the CMD and for distinguishing the white dwarfs (WDs) from brown dwarf (BD) candidates. Detection limits in the NIR are around F110W approx 26.5 mag and F160W approx27 mag, and in the optical around F775W approx 28 mag. Comparing our observed CMDs with theoretical models, we conclude that we have reached beyond the H-burning limit in our NIR CMD and are probably just above or around this limit in our optical-NIR CMDs. Thus, any faint NIR sources that have no optical counterpart are potential BD candidates, since the optical data are not deep enough to detect them. We visually inspected the positions of NIR sources which are fainter than the H-burning limit in F110W and for which the optical photometry did not return a counterpart. We found in total five sources for which we did not get an optical measurement. For four of these five sources, a faint optical counterpart could be visually identified, and an upper optical magnitude was estimated. Based on these upper optical magnitude limits, we conclude that one source is likely a WD, one source could either be a WD or BD candidate, and the remaining two sources agree with being BD candidates. For only one source no optical counterpart could be detected, which makes this source a good BD candidate. We conclude that we found in total four good BD candidates.Comment: ApJ accepted, 28 pages including 16 figure

Quantification of myocardial perfusion based on signal intensity of flow sensitized MRI

A new method to quantify myocardial perfusion was developed based on slice select (M S) and non-select (MG) inversion recovery acquisitions at a single inversion time. A modified Bloch equation was solved to obtain an analytical expression for perfusion (P) in terms of ΔM SG =M S-M G The average myocardial perfusion of healthy C57BL/6 mice measured using this technique (P=5.7±0.4 ml/g/min) agreed with that measured using traditional techniques and it had a high reproducibility with mean standard deviation of 3.6 % between repeated measures. Perfusion maps of ischemia-reperfusion mice showed significantly low perfusion (P=1.6±0.3 ml/g/min)intheinfarctedregionscomparedtothatof remote regions (P=4.1±0.3 ml/g/min,p=0.004). Backgroun

Isochrones and Luminosity Functions for Old White Dwarfs

Using a new grid of models of cooling white dwarfs, we calculate isochrones and luminosity functions in the Johnson-Kron/Cousins and HST filter sets for systems containing old white dwarfs. These new models incorporate a non-grey atmosphere which is necessary to properly describe the effects of molecular opacity at the cool temperatures of old white dwarfs. The various functions calculated and extensively tabulated and plotted are meant to be as utilitarian as possible for observers so all results are listed in quantities that observers will obtain. The tables and plots developed should eventually prove critical in interpreting the results of HST's Advanced Camera observations of the oldest white dwarfs in nearby globular clusters, in understanding the results of searches for old white dwarfs in the Galactic halo, and in determining ages for star clusters of all ages using white dwarfs. As a practical application we demonstrate the use of these results by deriving the white dwarf cooling age of the old Galactic cluster M67.Comment: 7 pages, 8 tables, accepted for publication in the Astrophysical Journa

Probing Dark Matter

Recent novel observations have probed the baryonic fraction of the galactic dark matter that has eluded astronomers for decades. Late in 1993, the MACHO and EROS collaborations announced in this journal the detection of transient and achromatic brightenings of a handful of stars in the Large Magellanic Cloud that are best interpreted as gravitational microlensing by low-mass foreground objects (MACHOS). This tantalized astronomers, for it implied that the population of cool, compact objects these lenses represent could be the elusive dark matter of our galactic halo. A year later in 1994, Sackett et al. reported the discovery of a red halo in the galaxy NGC 5907 that seems to follow the inferred radial distribution of its dark matter. This suggested that dwarf stars could constitute its missing component. Since NGC 5907 is similar to the Milky Way in type and radius, some surmised that the solution of the galactic dark matter problem was an abundance of ordinary low-mass stars. Now Bahcall et al., using the Wide-Field Camera of the recently repaired Hubble Space Telescope, have dashed this hope.Comment: 3 pages, Plain TeX, no figures, published as a News and Views in Nature 373, 191 (1995

ALMA Capabilities for Observations of Spectral Line Emission

The Atacama Large Millimeter/submillimeter Array (ALMA) combines large collecting area and location on a high dry site to provide it with unparalleled potential for sensitive millimeter/submillimeter spectral line observations. Its wide frequency coverage, superb receivers and flexible spectrometer will ensure that its potential is met. Since the 1999 meeting on ALMA Science\cite{RefA}, the ALMA team has substantially enhanced its capability for line observations. ALMA's sensitivity increased when Japan joined the project, bringing the 16 antennas of the Atacama Compcat Array (ACA), equivalent to eight additional 12m telescopes. The first four receiver cartridges for the baseline ALMA (Japan's entry has brought two additional bands to ALMA's receiver retinue) have been accepted, with performance above the already-challenging specifications. ALMA's flexibility has increased with the enhancement of the baseline correlator with additional channels and flexibility, and with the addition of a separate correlator for the ACA. As an example of the increased flexibility, ALMA is now capable of multi-spectral-region and multi-resolution modes. With the former, one might observe e.g. four separate transitions anywhere within a 2 GHz band with a high resolution bandwidth. With the latter, one might simultaneously observe with low spectral resolution over a wide bandwidth and with high spectral resolution over a narrow bandwidth; this mode could be useful for observations of pressure-broadened lines with narrow cores, for example. Several science examples illustrate ALMA's potential for transforming millimeter and submillimeter astronomy.Comment: 6 pages, for the Proceedings of Science with ALMA: a new era for Astrophysics: International Conference, 2006 held 13 - 17 November 2006 in Madrid, Spai