51 research outputs found
La «demitologización» de la imagen de Dios en la encíclica «Deus caritas est» de Benedicto XVI.
En el nihilismo contemporáneo,
o si se prefiere, en la postmodernidad,
se nota drásticamente el
desplazamiento del problema gnoseológico
de Dios. El conocimiento de
Dios, aunque difícil, siempre es posible.
Pero en el ateísmo nos encontramos
con la tesis de la imposibilidad de
conocer a Dios, sencillamente porque
no existe. Para el agnosticismo y el relativismo
contemporáneos la hipótesis
es que de Dios ni se sabe nada ni podrá
saberse nada. Para las ideologías
herederas del ateísmo el obrar fundamental
del hombre se dirige a crear
una nueva civilización fundada en una
economía política autónoma frente a
Dios.
El hombre sin embargo, no puede
olvidar a Dios sin olvidar también su
propia identidad. En el encuentro con
lo cotidiano vive en tensión, en lucha
interna. Busca los sustitutos para las
realidades a las que está ligado, pero
cae en sucedáneos del Absoluto del que había querido liberarse. Lo testimonian
los desarrollos de las llamadas
nuevas religiones, las sectas, la new age
y otros modelos esotéricos que quieren
sustituir a Cristo.
A la busca del hombre moderno,
con la afirmación existencial Dios es
amor, el Papa quiere dar una respuesta
a las dudas suscitadas en nuestra
época por las ideologías y los diversos
sistemas filosóficos. Parece decir abiertamente:
si Dios es amor, significa también
que no está muerto. Lo que está
agotado son las concepciones antropomórficas
y las caricaturescas que hemos
hecho de Él. Dios es amor no es
una de tantas imágenes sino el fundamento
y el criterio absoluto de todas
las imágenes que quieran acercarse al
rostro del Dios vivo.
El Papa actual, proveniente de una
cultura en la que a menudo se postulaba
una demitologización de la Biblia,
de una manera profundamente
serena demitologiza el rostro de Dios
que había deformado nuestra historia.
Adoptando un lenguaje humanista
quiere recordar que Cristo es el amor
revelado de Dios que se ha hecho
hombre por amor al hombre. Es un
Dios-amor en el hombre
Identification of Twinfilin-1 as a key regulator of cholangiocyte biological response to injury: evidence for a possible role of ageing in the progression of cholangiopathies
HDL cholesterol protects from liver injury in mice with intestinal specific LXRα activation
Background and aims: Liver X receptors (LXRs) exert anti-inflammatory effects even though their hepatic activation is associated with hypertriglyceridemia and hepatic steatosis. Selective induction of LXRs in the gut might provide protective signal(s) in the aberrant wound healing response that induces fibrosis during chronic liver injury, without hypertriglyceridemic and steatogenic effects. Methods: Mice with intestinal constitutive LXRα activation (iVP16-LXRα) were exposed to intraperitoneal injection of carbon tetrachloride (CCl4) for 8 weeks, and in vitro cell models were used to evaluate the beneficial effect of high-density lipoproteins (HDL). Results: After CCl4 treatment, the iVP16-LXRα phenotype showed reduced M1 macrophage infiltration, increased expression M2 macrophage markers, and lower expression of hepatic pro-inflammatory genes. This anti-inflammatory effect in the liver was also associated with decreased expression of hepatic oxidative stress genes and reduced expression of fibrosis markers. iVP16-LXRα exhibited increased reverse cholesterol transport in the gut by ABCA1 expression and consequent enhancement of the levels of circulating HDL and their receptor SRB1 in the liver. No hepatic steatosis development was observed in iVP16-LXRα. In vitro, HDL induced a shift from M1 to M2 phenotype of LPS-stimulated Kupffer cells, decreased TNFα-induced oxidative stress in hepatocytes and reduced NF-kB activity in both cells. SRB1 silencing reduced TNFα gene expression in LPS-stimulated KCs, and NOX-1 and IL-6 in HepG2. Conclusions: Intestinal activation of LXRα modulates hepatic response to injury by increasing circulating HDL levels and SRB1 expression in the liver, thus suggesting this circuit as potential actionable pathway for therapy
HCC development is associated to peripheral insulin resistance in a mouse model of NASH
NAFLD is the most common liver disease worldwide but it is the potential evolution to NASH and eventually to hepatocellular carcinoma (HCC), even in the absence of cirrhosis, that makes NAFLD of such clinical importance. Aim: we aimed to create a mouse model reproducing the pathological spectrum of NAFLD and to investigate the role of possible co-factors in promoting HCC. Methods: mice were treated with a choline-deficient L-amino-acid-defined-diet (CDAA) or its control (CSAA diet) and subjected to a low-dose i.p. injection of CCl 4 or vehicle. Insulin resistance was measured by the euglycemic-hyperinsulinemic clamp method. Steatosis, fibrosis and HCC were evaluated by histological and molecular analysis. Results: CDAA-treated mice showed peripheral insulin resistance at 1 month. At 1-3 months, extensive steatosis and fibrosis were observed in CDAA and CDAA+CCl4 groups. At 6 months, equal increase in steatosis and fibrosis was observed between the two groups, together with the appearance of tumor. At 9 months of treatment, the 100% of CDAA+ CCl4 treated mice revealed tumor versus 40% of CDAA mice. Insulin-like Growth Factor-2 (IGF-2) and Osteopontin (SPP-1) were increased in CDAA mice versus CSAA. Furthermore, Immunostaining for p-AKT, p-c-Myc and Glypican-3 revealed increased positivity in the tumors. Conclusions: the CDAA model promotes the development of HCC from NAFLD-NASH in the presence of insulin resistance but in the absence of cirrhosis. Since this condition is increasingly recognized in humans, our study provides a model that may help understanding mechanisms of carcinogenesis in NAFLD. © 2014 De Minicis et al
Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth
BACKGROUND/AIMS:
Incidence of cholangiocarcinoma is increasing worldwide, yet remaining highly aggressive and with poor prognosis. The mechanisms that drive cholangiocyte transition towards malignant phenotype are obscure. Cholangiocyte benign proliferation is subjected to a self-limiting mechanism based on the autocrine release of endogenous opioid peptides. Despite the presence of both, ligands interact with delta opioid receptor (OR), but not with microOR, with the consequent inhibition of cell growth. We aimed to verify whether cholangiocarcinoma growth is associated with failure of opioidergic regulation of growth control.
METHODS:
We evaluated the effects of OR selective agonists on cholangiocarcinoma cell proliferation, migration and apoptosis. Intracellular signals were also characterised.
RESULTS:
Activation of microOR, but not deltaOR, increases cholangiocarcinoma cell growth. Such an effect is mediated by ERK1/2, PI3K and Ca(2+)-CamKIIalpha cascades, but not by cAMP/PKA and PKCalpha. microOR activation also enhances cholangiocarcinoma cell migration and reduces death by apoptosis. The anti-apoptotic effect of microOR was PI3K dependent.
CONCLUSIONS:
Our data indicate that cholangiocarcinoma growth is associated with altered opioidergic regulation of cholangiocyte biology, thus opening new scenarios for future surveillance or early diagnostic strategies for cholangiocarcinoma
La «demitologización» de la imagen de Dios en la encíclica «Deus caritas est» de Benedicto XVI.
En el nihilismo contemporáneo,
o si se prefiere, en la postmodernidad,
se nota drásticamente el
desplazamiento del problema gnoseológico
de Dios. El conocimiento de
Dios, aunque difícil, siempre es posible.
Pero en el ateísmo nos encontramos
con la tesis de la imposibilidad de
conocer a Dios, sencillamente porque
no existe. Para el agnosticismo y el relativismo
contemporáneos la hipótesis
es que de Dios ni se sabe nada ni podrá
saberse nada. Para las ideologías
herederas del ateísmo el obrar fundamental
del hombre se dirige a crear
una nueva civilización fundada en una
economía política autónoma frente a
Dios.
El hombre sin embargo, no puede
olvidar a Dios sin olvidar también su
propia identidad. En el encuentro con
lo cotidiano vive en tensión, en lucha
interna. Busca los sustitutos para las
realidades a las que está ligado, pero
cae en sucedáneos del Absoluto del que había querido liberarse. Lo testimonian
los desarrollos de las llamadas
nuevas religiones, las sectas, la new age
y otros modelos esotéricos que quieren
sustituir a Cristo.
A la busca del hombre moderno,
con la afirmación existencial Dios es
amor, el Papa quiere dar una respuesta
a las dudas suscitadas en nuestra
época por las ideologías y los diversos
sistemas filosóficos. Parece decir abiertamente:
si Dios es amor, significa también
que no está muerto. Lo que está
agotado son las concepciones antropomórficas
y las caricaturescas que hemos
hecho de Él. Dios es amor no es
una de tantas imágenes sino el fundamento
y el criterio absoluto de todas
las imágenes que quieran acercarse al
rostro del Dios vivo.
El Papa actual, proveniente de una
cultura en la que a menudo se postulaba
una demitologización de la Biblia,
de una manera profundamente
serena demitologiza el rostro de Dios
que había deformado nuestra historia.
Adoptando un lenguaje humanista
quiere recordar que Cristo es el amor
revelado de Dios que se ha hecho
hombre por amor al hombre. Es un
Dios-amor en el hombre
Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients
Spondylodiscitis after lumbar microdiscectomy: effectiveness of two protocols of intraoperative antibiotic prophylaxis in 1167 cases.
Outcome dopo stimolazione vagale in soggetti con crisi di caduta e ritardo mentale
We evaluated the seizure outcome in 39 children and adolescents VNS implanted for intractable epilepsy with drop attacks and mental retardation. Twenty five patients suffered from severe partial epilepsy, 14 were affected by Lennox-Gastaut syndrome.We have been used a novel classification for outcome wich includes assessment of both seizure frequency and severity (Class I-VII). At the follow up date 8 patients were in Class I-III (seizure free or > 50% seizure reduction) . Eight patients were in Class IV (seizure number unchanged after VNS but significant reduction in seizure severity and duration).VNS has little efficacy on drop attacks, therefore callosotomy would be a better surgical option for this kind of seizures
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