Life of Lucius Compton : the mountaineer evangelist

https://place.asburyseminary.edu/firstfruitsheritagematerial/1167/thumbnail.jp

The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

Amyloid plaques are defining histopathologic lesions in the brains of Alzheimer's disease (AD) patients and are composed of the amyloid-beta peptide, which is widely considered to play a critical role in the pathogenesis of AD. The β-secretase, or β-site amyloid precursor protein cleaving enzyme 1 (BACE1; also called Asp2, memapsin 2), is the enzyme that initiates the generation of amyloid beta. Consequently, BACE1 is an attractive drug target for lowering cerebral levels of amyloid beta for the treatment or prevention of AD. Much has been learned about BACE1 since its discovery over 10 years ago. In the present article, we review BACE1 properties and characteristics, cell biology, in vivo validation, substrates, therapeutic potential, and inhibitor drug development. Studies relating to the physiological functions of BACE1 and the promise of BACE1 inhibition for AD will also be discussed. We conclude that therapeutic inhibition of BACE1 should be efficacious for AD, although careful titration of the drug dose may be necessary to limit mechanism-based side effects

Co-Grazing Beef Cattle and Goats in Kentucky

A two season grazing study of mixed (goats and beef cattle) species was conducted in 2006 and 2008 at Sebastian Farms in Breathitt County KY. The objective of this study was to determine if the order of mixed species grazing affected beef cattle and goat weight gain and goat exposure to the barber pole worm (Haemonchus contortus) in a rotational grazing system. In this study, two co-grazing management strategies were tested. In treatment 1, goats and cattle were rotationally grazed together. In treatment 2, goats rotated through pastures as first grazers followed by cattle. Each co-grazing treatment was assigned a set of four pastures similar in size, terrain and plant species composition. The stocking rate for each treatment was approximately 1.2 acres per animal unit (1 animal unit = 1,000 lbs live weight). Animal performance data was collected every 30 days during the grazing season. In 2007, the study was suspended due to extreme drought conditions. In 2006 and 2008 goat weight gain and FAMACHA scores were not affected by grazing treatment. In 2006, cattle weight gain was slightly higher for cows grazing with goats. In contrast, cows following goats in 2008 had the greatest weight gain. Based on field observations, beef cattle and goats were compatible grazers and no herd health issues were related to mixed species grazing during this study

Some NECESSARY AND SUFFICIENT CONDITIONS OF COMULTIPLICATION MODULE

In ring theory, if  and  be ideals of , then the multiplication of  and , which is defined by  is also ideal of . Motivated by the multiplication of two ideals, then can be defined a multiplication module, a special module which every submodule of  can be expressed as the multiplication of an ideal of ring and the module itself, and can simply be written as .  Furthermore, if   the module become a comultiplication module. By the definition, it concludes that every comultiplication module is a multiplication module but the converse is not necessarily applicable. Keywords:  annihilator, ideal, module, comultiplication module, multiplication module, ring, submodule

Crystalline Properties of Cassava (Manihot esculenta Crantz) Starch and Its Associated Biofoam

Making foam using starch as an alternative material to replace a conventional material, polystyrene, is one of the solutions to solve an environmental problem due to the waste of foam made from polystyrene cannot be degraded. This study aims to analyze the crystalline properties of cassava starch and biofoam made from it using X-ray diffraction (XRD) spectroscopy. From the XRD data of cassava starch, the peaks of 2θ were analyzed to determine the type of cassava starch used in this study. The index of crystallinity of both cassava starch and its associated biofoam was calculated from XRD data. XRD data of cassava starch show 4 main peaks of 2θ: 15.0◦ , 17.0◦ , 17.9◦ , and 23.0◦ , and 3 minor peaks at 11.0◦ , 20.0◦ , 26.0◦ . Based on the main peaks from this XRD data, cassava starch can be categorized as an A-type starch. For cassava starch biofoam, there is only 1 main peak of 2θ at 19.7◦ , and 5 minor peaks at 11.0◦ , 15.4◦ , 21.7◦ , 23.0◦ , and 26.4◦ . The decrease in the crystallinity from the starch to the associated biofoam is shown by the decrease in the index of crystallinity, which decreases from 41.0% in starch to 28.3% in biofoam

DAYA DUKUNG DAN INDEKS DAYA DUKUNG HIJAUAN ALAMI DI AREAL PERKEBUNAN KELAPA DALAM SEBAGAI PAKAN TERNAK RUMINANSIA DI KECAMATAN TANIWEL KABUPATEN SERAM BAGIAN BARAT

The purpose of this study was to determine carrying capacity and carrying capacity index of natural forage as ruminant feed, and to determine botanical compositions and forage production in the coconut plantation area, District of Taniwel, Western Seram Regency. Primary and secondary data were collected, and data collection was conducted by using purposive sampling method. Variables measured included botanical composition, forage production, forage carrying capacity, and carrying capacity index of natural forage. The results showed that 64,81% of forage botanical composition was grass, 26,47% was weeds, and 10,52% was legumes. The carrying capacity of native forage in the coconut plantation area was 1.515 ruminants for fresh forage and 1.177 for forage dry matter, while carrying capacity index of native forage was 2 indicating unsafety level of forage available for ruminant feeding

Further Constraints and Uncertainties on the Deep Seismic Structure of the Moon

The Apollo Passive Seismic Experiment (APSE) consisted of four 3-component seismometers deployed between 1969 and 1972, that continuously recorded lunar ground motion until late 1977. The APSE data provide a unique opportunity for investigating the interior of a planet other than Earth, generating the most direct constraints on the elastic structure, and hence the thermal and compositional evolution of the Moon. Owing to the lack of far side moonquakes, past seismic models of the lunar interior were unable to constrain the lowermost 500 km of the interior. Recently, array methodologies aimed at detecting deep lunar seismic reflections found evidence for a lunar core, providing an elastic model of the deepest lunar interior consistent with geodetic parameters. Here we study the uncertainties in these models associated with the double array stacking of deep moonquakes for imaging deep reflectors in the Moon. We investigate the dependency of the array stacking results on a suite of parameters, including amplitude normalization assumptions, polarization filters, assumed velocity structure, and seismic phases that interfere with our desired target phases. These efforts are facilitated by the generation of synthetic seismograms at high frequencies (approx. 1Hz), allowing us to directly study the trade-offs between different parameters. We also investigate expected amplitudes of deep reflections relative to direct P and S arrivals, including predictions from arbitrarily oriented focal mechanisms in our synthetics. Results from separate versus combined station stacking help to establish the robustness of stacks. Synthetics for every path geometry of data were processed identically to that done with data. Different experiments were aimed at examining various processing assumptions, such as adding random noise to synthetics and mixing 3 components to some degree. The principal stacked energy peaks put forth in recent work persist, but their amplitude (which maps into reflector impedance contrast) and timing (which maps into reflector depth) depend on factors that are not well constrained -- most notably, the velocity structure of the overlying lunar interior. Thus, while evidence for the lunar core remains strong, the depths of imaged reflectors have associated uncertainties that will require new seismic data and observations to constrain. These results strongly advocate further investigations on the Moon to better resolve the interior (e.g., Selene missions), for the Moon apparently has a rich history of construction and evolution that is inextricably tied to that of Earth

Experimental study of frost detectability on planetary surfaces using multicolor photometry and polarimetry

When the temperature and pressure conditions allow it, water ice can deposit as frost on the regolith of planetary surfaces. Frost is an important indicator of the surface physical conditions, and may trigger geological processes by its deposition and sublimation. This works aims to explore, experimentally, the possibility of detecting early stages of frost formation and to characterize its spectrophotometric and spectropolarimetric signatures in visible reflected light. We deposit ice on top of different regolith simulants, measuring the dust temperature, the thickness, and the morphology of the frost through a microscope, while measuring the reflected light at phase angles of 50° and 61°, and the linear polarization at phase angles of 5° and 16°, at three different wavelengths (450, 550, and 750 nm). We show that both the spectral slope (in particular between 450–550 nm), and the difference of polarization between 450 and 750 nm are efficient methods to detect frost layers with thicknesses as low as 10 to 20 μm. Furthermore, we find that the linear polarization at 16° relates to the temperature of the regolith i.e. the type of the deposited ice crystalline structure