Data Dissemination Performance in Large-Scale Sensor Networks

As the use of wireless sensor networks increases, the need for (energy-)efficient and reliable broadcasting algorithms grows. Ideally, a broadcasting algorithm should have the ability to quickly disseminate data, while keeping the number of transmissions low. In this paper we develop a model describing the message count in large-scale wireless sensor networks. We focus our attention on the popular Trickle algorithm, which has been proposed as a suitable communication protocol for code maintenance and propagation in wireless sensor networks. Besides providing a mathematical analysis of the algorithm, we propose a generalized version of Trickle, with an additional parameter defining the length of a listen-only period. This generalization proves to be useful for optimizing the design and usage of the algorithm. For single-cell networks we show how the message count increases with the size of the network and how this depends on the Trickle parameters. Furthermore, we derive distributions of inter-broadcasting times and investigate their asymptotic behavior. Our results prove conjectures made in the literature concerning the effect of a listen-only period. Additionally, we develop an approximation for the expected number of transmissions in multi-cell networks. All results are validated by simulations

Queues with random back-offs

We consider a broad class of queueing models with random state-dependent vacation periods, which arise in the analysis of queue-based back-off algorithms in wireless random-access networks. In contrast to conventional models, the vacation periods may be initiated after each service completion, and can be randomly terminated with certain probabilities that depend on the queue length. We examine the scaled queue length and delay in a heavy-traffic regime, and demonstrate a sharp trichotomy, depending on how the activation rate and vacation probability behave as function of the queue length. In particular, the effect of the vacation periods may either (i) completely vanish in heavy-traffic conditions, (ii) contribute an additional term to the queue lengths and delays of similar magnitude, or even (iii) give rise to an order-of-magnitude increase. The heavy-traffic asymptotics are obtained by combining stochastic lower and upper bounds with exact results for some specific cases. The heavy-traffic trichotomy provides valuable insight in the impact of the back-off algorithms on the delay performance in wireless random-access networks

MR/GR Signaling in the Brain during the Stress Response

This contribution is about mineralocorticoid receptors (MRs) in their capacity as mediators of glucocorticoid action in the brain. This paradox has evolved because MRs are promiscuous and bind with high-affinity cortisol and corticosterone as well as aldosterone, deoxycorticosterone, and progesterone. The MRs “see,” however, predominantly glucocorticoids, because of their 100–1000-fold excess over aldosterone; bioavailability is further enhanced because of local regeneration of glucocorticoids by 11βOH-steroid dehydrogenase (HSD-1). In contrast to these glucocorticoid-preferring MR, the evolutionary later appearance of aldosterone-selective MR in epithelial cells depends on co-localization with the oxidase 11β-hydroxysteroid-dehydrogenase type 2 (HSD-2) in a few hundred neurons in the nucleus tractus solitarii (NTS), which innervate frontal brain regions to regulate cognitive, emotional, and motivational aspects of salt appetite. The glucocorticoid-MRs and classical glucocorticoid receptors (GRs) mediate in a complementary manner the glucocorticoid coordination of circadian events and mediate the regulation of stress coping and adaptation. If an individual is exposed to a threat, MRs are crucial for the selection of a particular coping style, which is via GR activation subsequently stored in the memory for future use. Our contribution is concluded with the notion that an imbalance in MR- and GR-mediated actions increases susceptibility to stress-related disorders

Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples

Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment. We subsequently examined potential use of dried blood spots as sample procedure for TDM. TDM was found to be an important component of clinical care for many (but not all) pulmonary infections. For gentamicin, linezolid, voriconazole and posaconazole dried blood spot methods and their use in TDM were already evident in literature. For glycopeptides, beta-lactam antibiotics and fluoroquinolones it was determined that development of a dried blood spot (DBS) method could be useful. This review identifies specific antibiotics for which development of DBS methods could support the optimization of treatment of pulmonary infections

Structural investigation and strain analysis of a polyphase flower structure in the Lower Saxony Basin, Germany

The Lower Saxony Basin (LSB) is a part of the post-Variscan Central European Basin System. We used a 3-D reflection seismic dataset in the northern LSB, provided by RWE-DEA AG, Hamburg (c.f. Lohr et al. submitted) for our investigation, which is concerned with the detailed structural and kinematic analysis of a flower structure within Mesozoic strata. This data is used in turn to determine input parameters for further 3-D geometrical retro-deformation. The retro-deformation verifies our assumptions about the structure and tectonic processes, and gives further information about sub-seismic strain distribution with respect to the branch faults of the flower structure.conferenc

Measurement and prediction of the centering effect of a profiled roll on steel strips

In a steel continuous processing line, the strip passes over an important number of rolls and strip walking can occur due to strip defects, roll profile or roll misalignment. Since decades, two solutions are used in order to keep a strip centered in the line : deflection rolls are profiled (with crowned or tapered shapes) and steering rolls are implemented, in different part of the lines.As in other industries, the constant challenge for a line manager in the steel industry is to increase the productivity of the line and to adapt the lines to new products.To achieve these goals on pickling lines or continuous annealing lines, it is necessary in some cases to know precisely about the centering effect of profiled rolls on the strip. This data can be used either to improve the strip centering by increasing the roll profile or to avoid other defects as wrinkles, by reducing the crown without increasing strip walking.In order to quantify the centering efficiency of a roll, Irsid and Sollac developed a theoretical model for calculating the strip position after a profiled roll and compared it to experimental data measured on two pilot lines

Kinematics and Convergent Tectonics of the Northwestern South American Plate During the Cenozoic

The interaction of the northern Nazca and southwestern Caribbean oceanic plates with northwestern South America (NWSA) and the collision of the Panama-Choco arc (PCA) have significant implications on the evolution of the northern Andes. Based on a quantitative kinematic reconstruction of the Caribbean and Farallon/Farallon-derived plates, we reconstructed the subducting geometries beneath NWSA and the PCA accretion to the continent. The persistent northeastward migration of the Caribbean plate relative to NWSA in Cenozoic time caused the continuous northward advance of the Farallon-Caribbean plate boundary, which in turn resulted in its progressive concave trench bending against NWSA. The increasing complexity during the Paleogene included the onset of Caribbean shallow subduction, the PCA approaching the continent, and the forced shallow Farallon subduction that ended in the fragmentation of the Farallon Plate into the Nazca and Cocos plates and the Coiba and Malpelo microplates by the late Oligocene. The convergence tectonics after late Oligocene comprised the accretional process of the PCA to NWSA, which evolved from subduction erosion of the forearc to collisional tectonics by the middle Miocene, as well as changes of convergence angle and slab dip of the Farallon-derived plates, and the attachment of the Coiba and Malpelo microplates to the Nazca plate around 9 Ma, resulting in a change of convergence directions. During the Pliocene, the Nazca slab broke at 5.5°N, shaping the modern configuration. Overall, the proposed reconstruction is supported by geophysical data and is well correlated with the magmatic and deformation history of the northern Andes