THE RELATIONSHIP BETWEEN MUSCULOSKELETAL STRENGTH, PHYSIOLOGICAL CHARACTERISTICS, AND KNEE KINESTHESIA FOLLOWING FATIGUING EXERCISE

Fatiguing exercise may result in impaired functional joint stability and increased risk of unintentional injury. While there are several musculoskeletal and physiological characteristics related to fatigue onset, their relationship with proprioceptive changes following fatigue has not been examined. The purpose of this study was to establish the relationship between musculoskeletal and physiological characteristics and changes in proprioception, measured by threshold to detect passive motion (TTDPM), following fatiguing exercise. Twenty, physically active females participated (age: 28.65 ± 5.6 years, height: 165.6 ± 4.3 cm, weight: 61.8 ± 8.0 kg, BMI: 22.5± 2.3 kg/m2, BF: 23.3 ± 5.4%). During Visit 1, subjects completed an exercise history and 24-hour dietary questionnaire, and body composition, TTDPM familiarization, isokinetic knee strength, and maximal oxygen uptake/lactate threshold assessments. During Visit 2, subjects completed TTDPM and isometric knee strength testing prior to and following a fatiguing exercise protocol. Wilcoxon signed rank tests determined TTDPM and isometric knee strength changes from pre- to post- fatigue. Spearman’s rho correlation coefficients determined the relationship between strength and physiological variables with pre- to post-fatigue changes in TTDPM and with pre-fatigue and post-fatigue TTDPM in extension and flexion (α=0.05). No significant differences were demonstrated from pre-fatigue to post-fatigue TTDPM despite a significant decrease in isometric knee flexion strength (P<0.01) and flexion/extension ratio (P<0.05) following fatigue. No significant correlations were observed between strength or physiological variables and changes in TTDPM from pre- to post-fatigue in extension or flexion. Flexion/extension ratio was significantly correlated with pre-fatigue TTDPM in extension (r=-0.231, P<0.05). Peak oxygen uptake was significantly correlated with pre-fatigue (r=-0.500, P<0.01) and post-fatigue (r=-0.520, P<0.05) TTDPM in extension. No significant relationships were demonstrated between musculoskeletal and physiological characteristics and changes in TTDPM following fatigue. The results suggest that highly trained individuals may have better proprioception, and that the high fitness level of subjects in this investigation may have contributed to absence of TTDPM deficits following fatigue despite reaching a high level of perceptual and physiological fatigue. Future studies should consider various subject populations, other musculoskeletal strength characteristics, and different modalities of proprioception to determine the most important contributions to proprioceptive changes following fatigue

Face Detection with Effective Feature Extraction

There is an abundant literature on face detection due to its important role in many vision applications. Since Viola and Jones proposed the first real-time AdaBoost based face detector, Haar-like features have been adopted as the method of choice for frontal face detection. In this work, we show that simple features other than Haar-like features can also be applied for training an effective face detector. Since, single feature is not discriminative enough to separate faces from difficult non-faces, we further improve the generalization performance of our simple features by introducing feature co-occurrences. We demonstrate that our proposed features yield a performance improvement compared to Haar-like features. In addition, our findings indicate that features play a crucial role in the ability of the system to generalize.Comment: 7 pages. Conference version published in Asian Conf. Comp. Vision 201

Nigrosine staining of wheat endosperm proteolipid patterns on starch gels

We have previously characterized a group of proteolipids from wheat endosperm, designated CM proteins, which are soluble in chloroformmethanol (2:1, v/v) and have a molecular weight lower than 25,000 daltons (1-3). These have been also studied by Redman and Ewart (4). The CM proteins are suitably fractionated into several components by starch gel electrophoresis at pH 3.2 (1). A sensitive staining procedure was required in connection with genetic studies of these proteins because phenotypes had to be ascertained in small endosperm fractions dissected without impairing normal germination and plant development. We report here on Nigrosine staining conditions for CM proteins under which high sensitivity and selectivity are achieve

Accuracy of Recall of Musculoskeletal Injuries in Elite Military Personnel: A Cross-Sectional Study

Background Self-reported data are often used in research studies among military populations. Objective The accuracy of self-reported musculoskeletal injury data among elite military personnel was assessed for issues with recall. Design Cross-sectional study. Setting Applied research laboratory at a military installation. Participants A total of 101 subjects participated (age 28.5±5.6 years). Study participants were active duty military personnel, with no conditions that precluded them from full duty. Primary and secondary outcome measures Self-reported and medical record reviewed injuries that occurred during a 1-year period were matched by anatomic location, injury side (for extremity injuries), and injury year and type. The accuracy of recall was estimated as the per cent of medical record reviewed injuries correctly recalled in the self-report. The effect of injury anatomic location, injury type and severity and time since injury, on recall, was also assessed. Injuries were classified as recent (≤4 years since injury) or old injuries (\u3e4 years since injury). Recall proportions were compared using Fisher\u27s exact tests. ResultsA total of 374 injuries were extracted from the subjects\u27 medical records. Recall was generally low (12.0%) and was not different between recent and old injuries (P=0.206). Injury location did not affect recall (P=0.418). Recall was higher for traumatic fractures as compared with less severe non-fracture injuries (P values 0.001 to \u3c0.001). Recall for non-fracture injuries was higher for recent as compared with old injuries (P=0.033). This effect of time since injury on recall was not observed for fractures (P=0.522). Conclusions The results of this study highlight the importance of weighing the advantages and disadvantages of self-reported injury data before their use in research studies in military populations and the need for future research to identify modifiable factors that influence recall

Implications of Lorentz covariance for the guidance equation in two-slit quantum interference

It is known that Lorentz covariance fixes uniquely the current and the associated guidance law in the trajectory interpretation of quantum mechanics for spin particles. In the non-relativistic domain this implies a guidance law for the electron which differs by an additional spin-dependent term from that originally proposed by de Broglie and Bohm. In this paper we explore some of the implications of the modified guidance law. We bring out a property of mutual dependence in the particle coordinates that arises in product states, and show that the quantum potential has scalar and vector components which implies the particle is subject to a Lorentz-like force. The conditions for the classical limit and the limit of negligible spin are given, and the empirical sufficiency of the model is demonstrated. We then present a series of calculations of the trajectories based on two-dimensional Gaussian wave packets which illustrate how the additional spin-dependent term plays a significant role in structuring both the individual trajectories and the ensemble. The single packet corresponds to quantum inertial motion. The distinct features encountered when the wavefunction is a product or a superposition are explored, and the trajectories that model the two-slit experiment are given. The latter paths exhibit several new characteristics compared with the original de Broglie-Bohm ones, such as crossing of the axis of symmetry.Comment: 27 pages including 6 pages of figure

Erlotinib dosing-to-rash: A phase II intrapatient dose escalation and pharmacologic study of erlotinib in previously treated advanced non-small cell lung cancer

Background: To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics (PD) of higher doses of erlotinib. Methods: Patients initially received erlotinib 150 mg per day. The dose was successively increased in each patient to that associated with a TR. Anticancer activity was evaluated. Plasma, skin, and hair were sampled for PK and PD studies. Results: Erlotinib dose escalation to 200-475 mg per day was feasible in 38 (90%) of 42 patients. Twenty-four (57%) patients developed a TR, but 19 (79%) did so at 150 mg per day. Five (12%) patients, all of whom developed a TR, had a partial response. Median progression-free survival (PFS) was 2.3 months (95% CI: 1.61, 4.14); median PFS was 3.5 months and 1.9 months, respectively, for patients who did and did not experience a TR (hazard ratio, 0.51; P0.051). Neither rash severity nor response correlated with erlotinib exposure. Conclusion: Intrapatient dose escalation of erlotinib does not appreciably increase the propensity to experience a maximal level of tolerable skin toxicity, or appear to increase the anticancer activity of erlotinib in NSCLC

Influence of Halides on the Optical Properties of Silicon Quantum Dots

Silicon quantum dots (Si-QDs) have received substantial attention over the last two decades owing to their abundance, biocompatibility, and optical properties. Similar to their group II−VI and III−V quantum dot counterparts, hydride-terminated Si-QDs with diameters smaller than 5 nm can exhibit size-dependent photoluminescence (PL) in the visible spectral region. However, the hydride surface is highly susceptible to oxidation and requires further modification to passivate it and render the QDs soluble in common solvents