A physical model for seismic noise generation from sediment transport in rivers

Measuring sediment flux in rivers remains a significant problem in studies of landscape evolution. Recent studies suggest that observations of seismic noise near rivers can help provide such measurements, but the lack of models linking observed seismic quantities to sediment flux has prevented the method from being used. Here, we develop a forward model to describe the seismic noise induced by the transport of sediment in rivers. The model provides an expression for the power spectral density (PSD) of the Rayleigh waves generated by impulsive impacts from saltating particles which scales linearly with the number of particles of a given size and the square of the linear momentum. After incorporating expressions for the impact velocity and rate of impacts for fluvially transported sediment, we observe that the seismic noise PSD is strongly dependent on the sediment size, such that good constraints on grain size distribution are needed for reliable estimates of sediment flux based on seismic noise observations. The model predictions for the PSD are consistent with recent measurements and, based on these data, a first attempt at inverting seismic noise for the sediment flux is provided

Tidal modulation of ice shelf buttressing stresses

Ocean tides influence the flow of marine-terminating glaciers. Observations indicate that the large fortnightly variations in ice flow at Rutford Ice Stream in West Antarctica originate in the floating ice shelf. We show that nonlinear variations in ice shelf buttressing driven by tides can produce such fortnightly variations in ice flow. These nonlinearities in the tidal modulation of buttressing stresses can be caused by asymmetries in the contact stress from migration of the grounding line and bathymetric pinning points beneath the ice shelf. Using a simple viscoelastic model, we demonstrate that a combination of buttressing and hydrostatic stress variations can explain a diverse range of tidal variations in ice shelf flow, including the period, phase and amplitude of flow variations observed at Rutford and Bindschadler Ice Streams

Isometric Skeletal Muscle Contractile Properties in Common Strains of Male Laboratory Mice

Assessing contractile function of skeletal muscle in murine models is a commonly employed laboratory technique that investigators utilize to measure the impact of genetic manipulations, drug efficacy, or other therapeutic interventions. Often overlooked is the potential for the strain of the mouse to influence the functional properties of the skeletal muscle. Thus, we sought to characterize commonly assessed isometric force measures in the hindlimb muscles across a variety of mouse strains. Using 6-8-week-old male mice, we measured isometric force, fatigue susceptibility, relaxation kinetics, muscle mass, myofiber cross-sectional area, and fiber type composition of the extensor digitorum longus (EDL) and soleus muscles in C57BL/6NJ, BALB/cJ, FVB/NJ, C57BL/6J, and C57BL/10 mice. The data demonstrate both unique differences and a number of similarities between both muscles in the various genetic backgrounds of mice. Soleus muscle specific force (i.e., force per unit size) exhibited higher variation across strains while specific force of the EDL muscle exhibited minimal variation. In contrast, absolute force differed only in a few mouse strains whereas analysis of muscle morphology revealed many distinctions when compared across all the groups. Collectively, the data suggest that the strain of the mouse can potentially influence the measured biological outcome and may possibly promote a synergistic effect with any genetic manipulation or therapeutic intervention. Thus, it is critical for the investigator to carefully consider the genetic background of the mouse used in the experimental design and precisely document the strain of mouse employed during publication

A retrospective analysis of clinical use of alirocumab in lipoprotein apheresis patients

BACKGROUND: The previously published ODYSSEY ESCAPE trial demonstrated a significant reduction in the use of lipoprotein apheresis for heterozygous familial hypercholesterolemia (HeFH) patients when placed on alirocumab 150 mg every 2 weeks. In patients with HeFH who have consistently elevated levels of low-density lipoprotein cholesterol (LDL-C) despite maximally tolerated statin therapy, current lipid guidelines recommend apheresis. Although apheresis reduces LDL-C levels by 50%-75%, it must be repeated, as frequently as every 1-2 weeks. OBJECTIVE: To assess clinical experience with apheresis and alirocumab for patients in a real-world practice setting. METHODS: This retrospective review included patients from 5 apheresis centers who were treated with apheresis and had started alirocumab therapy. In addition to LDL-C levels, total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides, and particle numbers were evaluated if data were available. RESULTS: Eleven of the 25 (44%) patients discontinued apheresis completely after initiation of alirocumab therapy, having achieved LDL-C \u3c70 mg/dL or \u3e50% reduction from baseline levels. Among the 14 patients who remained on apheresis, seven decreased the frequency of apheresis sessions. No significant safety problems were reported. CONCLUSION: Alirocumab lowered LDL-C levels by an average of 55.5% in patients receiving apheresis for elevated LDL-C. Seventy-two percent of patients on alirocumab therapy discontinued or reduced the frequency of apheresis treatment. However, some patients continued to require apheresis due to elevated lipoprotein(a), extremely elevated LDL-C, or if alirocumab therapy was discontinued due to less than anticipated LDL-C reduction

Ice fabric in an Antarctic ice stream interpreted from seismic anisotropy

Here we present new measurements of an anisotropic ice fabric in a fast moving (377 ma−1) ice stream in West Antarctica. We use ∼6000 measurements of shear wave splitting observed in microseismic signals from the bed of Rutford Ice Stream, to show that in contrast to large-scale ice flow models, which assume that ice is isotropic, the ice in Rutford Ice Stream is dominated by a previously unobserved type of partial girdle fabric. This fabric has a strong directional contrast in mechanical properties, shearing 9.1 times more easily along the ice flow direction than across flow. This observed fabric is likely to be widespread and representative of fabrics in other ice streams and large glaciers, suggesting it is essential to consider anisotropy in data-driven models to correctly predict ice loss and future flow in these regions. We show how passive microseismic monitoring can be effectively used to provide these data

The Golden Shiner Grading Assessment Model

Abstract Go lden shiners Notemigonus crysoleucas are typically graded in concrete vats having a rectangular cross section. Aluminum fra mes fitted with panels of uniformly spaced, vertical rods (bar graders) are used to separate golden shiners having similar weight and length fro m a mixed-size aggregation. Investigation revealed that no quantitative method for estimat ing bar grader effectiveness existed, so a Microsoft © Exce l application was developed. The golden shiner assessment model presents product quality information for g raded golden shiners Notemigonus crysoleucas. Quality assurance data includes an estimate of the number of fish per kilogram (kg), weight in kg per 1,000 fish, and an assessment of grading effectiveness. Standard weight calculations give benchmark weight to length criteria for graded golden shiners, whereas relative weight provides a general indicator of health, and a means to estimate the effectiveness of a feed ing regimen. This model serves as an assessment tool for researchers, a management tool for producers, and a source of important product informat ion for purchasers

Teachers\u27 Awareness of Their Diverse Classrooms: The Nature of Elementary Teachers\u27 Reflections on Their Science Teaching Practice

This multiple case study examined the reflections of elementary teachers as they taught science to English language learners (ELLs). The six participants in this study developed explanations about their science teaching with ELLs as they engaged in reflective practice using video-based tools during a professional development experience. Open coding was used to analyze the data and cross-case comparison identified similarities and differences among the participants’ cases. Participants’ reflections indicated that knowledge of their students’ culture and backgrounds influenced their teaching practices and the focus of their reflections. Themes that emerged from participants’ reflections related to navigating the school world, managing the technical classroom, negotiating barriers, nurturing all students, and understanding learning. Findings illustrate the importance of examining teachers’ reflective writings in order to develop an understanding of how they use students’ backgrounds to inform their teaching practice and how they develop their science teaching practice with ELLs