553 research outputs found
A giant, periodic flare from the soft gamma repeater SGR1900+14
Soft gamma repeaters are high-energy transient sources associated with
neutron stars in young supernova remnants. They emit sporadic, short (~ 0.1 s)
bursts with soft energy spectra during periods of intense activity. The event
of March 5, 1979 was the most intense and the only clearly periodic one to
date. Here we report on an even more intense burst on August 27, 1998, from a
different soft gamma repeater, which displayed a hard energy spectrum at its
peak, and was followed by a ~300 s long tail with a soft energy spectrum and a
dramatic 5.16 s period. Its peak and time integrated energy fluxes at Earth are
the largest yet observed from any cosmic source. This event was probably
initiated by a massive disruption of the neutron star crust, followed by an
outflow of energetic particles rotating with the period of the star. Comparison
of these two bursts supports the idea that magnetic energy plays an important
role, and that such giant flares, while rare, are not unique, and may occur at
any time in the neutron star's activity cycle.Comment: Accepted for publication in Natur
Breast cancer in lesbians and bisexual women: Systematic review of incidence, prevalence and risk studies
This article is made available through the Brunel Open Access Publishing Fund. © 2013 Meads and Moore; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.Background: The UK Parliamentary Enquiry and USA Institute of Medicine state that lesbians may be at a higher risk of breast cancer but there is insufficient information. Lesbians and bisexual (LB) women have behavioural risk-factors at higher rates compared to heterosexuals such as increased alcohol intake and higher stress levels. Conversely, breast cancer rates are higher in more affluent women yet income levels in LB women are relatively low. This systematic review investigated all evidence on whether there is, or likely to be, higher rates of breast cancer in LB women. Methods: Cochrane library (CDSR, CENTRAL, HTA, DARE, NHSEED), MEDLINE, EMBASE, PsychINFO, CAB abstracts, Web of Science (SCI, SSCI), SIGLE and Social Care Online databases were searched to October 2013. Unpublished research and specific lesbian, gay and bisexual websites were checked, as were citation lists of relevant papers. Included were studies in LB populations reporting breast cancer incidence or prevalence rates, risk model results or risk-factor estimates. Inclusions, data-extraction and quality assessment were by two reviewers with disagreements resolved by discussion. Results: Searches found 198 references. No incidence rates were found. Nine studies gave prevalence estimates - two showed higher, four showed no differences, one showed mixed results depending on definitions, one had no comparison group and one gave no sample size. All studies were small with poor methodological and/or reporting quality. One incidence modelling study suggested a higher rate. Four risk modelling studies were found, one Rosner-Colditz and three Gail models. Three suggested higher and one lower rate in LB compared to heterosexual women. Six risk-factor estimates suggested higher risk and one no difference between LB and heterosexual women. Conclusions: The only realistic way to establish rates in LB women would be to collect sexual orientation within routine statistics, including cancer registry data, or from large cohort studies
No effect of aspirin on mammographic density in a randomized controlled clinical trial.
BACKGROUND: Epidemiologic studies suggest a reduced risk of breast cancer among women who regularly use aspirin; a plausible mechanism is through aspirin effect on mammographic breast density, a breast cancer risk factor, possibly mediated through aspirin interference with estrogen synthesis. METHODS: In a 2-arm randomized placebo-controlled clinical trial, we evaluated the effects of 6-month administration of 325 mg/day aspirin on total mammographic breast dense area and percent of the mammographic breast image occupied by dense areas (% density) in 143 postmenopausal women. Eligible women, recruited from 2005 to 2007, were healthy, not taking hormone therapy, with elevated mammographic breast density (American College of Radiology Breast Imaging Reporting and Data System density category 2, 3, or 4) within 6 months before enrollment. RESULTS: Women were a mean (SD) 59.5 (5.5) years. Geometric mean baseline percent density was 17.6% (95% confidence interval, 14.8-20.9) in women randomized to aspirin and 19.2% (95% confidence interval, 16.3-22.7) in women randomized to placebo. Percent density decreased in women randomized to aspirin by an absolute 0.8% versus an absolute decrease of 1.2% in controls (P = 0.84). Total breast area and dense area decreased to a similar degree in women assigned to aspirin and in those assigned to placebo, with no statistically significant differences between trial arms. CONCLUSIONS: A single daily administration of adult-dose aspirin for 6 months had no effect on mammographic density in postmenopausal women. If aspirin affects breast cancer risk in postmenopausal women, it may do so through alternative pathways than mammographic breast density. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1524-30)
Investigation of Primordial Black Hole Bursts using Interplanetary Network Gamma-ray Bursts
The detection of a gamma-ray burst (GRB) in the solar neighborhood would have
very important implications for GRB phenomenology. The leading theories for
cosmological GRBs would not be able to explain such events. The final bursts of
evaporating Primordial Black Holes (PBHs), however, would be a natural
explanation for local GRBs. We present a novel technique that can constrain the
distance to gamma-ray bursts using detections from widely separated,
non-imaging spacecraft. This method can determine the actual distance to the
burst if it is local. We applied this method to constrain distances to a sample
of 36 short duration GRBs detected by the Interplanetary Network (IPN) that
show observational properties that are expected from PBH evaporations. These
bursts have minimum possible distances in the 10^13-10^18 cm (7-10^5 AU) range,
consistent with the expected PBH energetics and with a possible origin in the
solar neighborhood, although none of the bursts can be unambiguously
demonstrated to be local. Assuming these bursts are real PBH events, we
estimate lower limits on the PBH burst evaporation rate in the solar
neighborhood.Comment: Accepted to the Astrophysical Journal (9 Figures, 3 Tables
Multi-wavelength observations and modelling of a canonical solar flare
This paper investigates the temporal evolution of temperature, emission
measure, energy loss and velocity in a C-class solar flare from both an
observational and theoretical perspective. The properties of the flare were
derived by following the systematic cooling of the plasma through the response
functions of a number of instruments -- RHESSI (>5 MK), GOES-12 (5-30 MK),
TRACE 171 A (1 MK) and SOHO/CDS (~0.03-8 MK). These measurements were studied
in combination with simulations from the 0-D EBTEL model. At the flare on-set,
upflows of ~90 km s-1 and low level emission were observed in Fe XIX,
consistent with pre-flare heating and gentle chromospheric evaporation. During
the impulsive phase, upflows of ~80 km s-1 in Fe XIX and simultaneous downflows
of 20 km s-1 in He I and O V were observed, indicating explosive chromospheric
evaporation. The plasma was subsequently found to reach a peak temperature of
~13 MK in approximately 10 minutes. Using EBTEL, conduction was found to be the
dominant loss mechanism during the initial ~300s of the decay phase. It was
also found to be responsible for driving gentle chromospheric evaporation
during this period. As the temperature fell below ~8 MK, and for the next
~4,000s, radiative losses were determined to dominate over conductive losses.
The radiative loss phase was accompanied by significant downflows of <40 km s-1
in O V. This is the first extensive study of the evolution of a canonical solar
flare using both spectroscopic and broad-band instruments in conjunction with a
hydrodynamic model. While our results are in broad agreement with the standard
flare model, the simulations suggest that both conductive and non-thermal beam
heating play important roles in heating the flare plasma during the impulsive
phase of at least this event.Comment: 10 pages, 7 figures, 2 tables. Accepted for publication in A&
LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation
Transplantation with donor corneas is the mainstay for treating corneal blindness, but a severe worldwide shortage necessitates the development of other treatment options. Corneal perforation from infection or inflammation is sealed with cyanoacrylate glue. However, the resulting cytotoxicity requires transplantation. LiQD Cornea is an alternative to conventional corneal transplantation and sealants. It is a cell-free, liquid hydrogel matrix for corneal regeneration, comprising short collagen-like peptides conjugated with polyethylene glycol and mixed with fibrinogen to promote adhesion within tissue defects. Gelation occurs spontaneously at body temperature within 5 min. Light exposure is not required-particularly advantageous because patients with corneal inflammation are typically photophobic. The self-assembling, fully defined, synthetic collagen analog is much less costly than human recombinant collagen and reduces the risk of immune rejection associated with xenogeneic materials. In situ gelation potentially allows for clinical application in outpatient clinics instead of operating theaters, maximizing practicality, and minimizing health care costs
Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial
Exercise and the Prevention of Oesophageal Cancer (EPOC) study protocol: a randomized controlled trial of exercise versus stretching in males with Barrett's oesophagus
<p>Abstract</p> <p>Background</p> <p>Chronic gastro-oesophageal reflux disease and excessive body fat are considered principal causes of Barrett's oesophagus (a metaplastic change in the cells lining the oesophagus) and its neoplastic progression, oesophageal adenocarcinoma. Metabolic disturbances including altered levels of obesity-related cytokines, chronic inflammation and insulin resistance have also been associated with oesophageal cancer development, especially in males. Physical activity may have the potential to abrogate metabolic disturbances in males with Barrett's oesophagus and elicit beneficial reductions in body fat and gastro-oesophageal reflux symptoms. Thus, exercise may be an effective intervention in reducing oesophageal adenocarcinoma risk. However, to date this hypothesis remains untested.</p> <p>The 'Exercise and the Prevention of Oesophageal Cancer Study' will determine whether 24 weeks of exercise training will lead to alterations in risk factors or biomarkers for oesophageal adenocarcinoma in males with Barrett's oesophagus. Our primary outcomes are serum concentrations of leptin, adiponectin, tumour necrosis factor-alpha, C-reactive protein and interleukin-6 as well as insulin resistance. Body composition, gastro-oesophageal reflux disease symptoms, cardiovascular fitness and muscular strength will also be assessed as secondary outcomes.</p> <p>Methods/Design</p> <p>A randomized controlled trial of 80 overweight or obese, inactive males with Barrett's oesophagus will be conducted in Brisbane, Australia. Participants will be randomized to an intervention arm (60 minutes of moderate-intensity aerobic and resistance training, five days per week) or a control arm (45 minutes of stretching, five days per week) for 24 weeks. Primary and secondary endpoints will be measured at baseline (week 0), midpoint (week 12) and at the end of the intervention (week 24).</p> <p>Discussion</p> <p>Due to the increasing incidence and very high mortality associated with oesophageal adenocarcinoma, interventions effective in preventing the progression of Barrett's oesophagus are urgently needed. We propose that exercise may be successful in reducing oesophageal adenocarcinoma risk. This primary prevention trial will also provide information on whether the protective association between physical activity and cancer is causal.</p> <p>Trial Registration</p> <p>ACTRN12609000401257</p
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