Product architecture management - An approach to product life cycle

Today a lot of small, medium and also large companies have a project organizational setup. This means that the major part of the development activities are gathered thru the conduction of a project that at its completion will deliver a new version of the product. In this situation managing versions and resources for some of the product components (subsystems) could be a problem or performed in a non efficient way. This paper shows the approach applied in a company producing machines for the food industry. The methodology is based on the application of PLC (Product Life Cycle) principles aiming at the rationalization of the decisions made during the planning, analysis and implementation phases. The goal of the approach is to help designers and product architects to correlate the needs of projects stakeholders (requirements) with other needs related to the product strategy and roadmap in order to improve efficiency in terms of resource management, product variants and other aspects that affect the life cycle of the product

Value chain vs life cycle approach for product extensions

The methodology presented in this paper aims at supporting the whole needs and the Stakeholder Requirements definition in product development or product extension projects. To achieve that goal, the methodology forces to take into account the relevant Stakeholders and the Product Life-Cycle phases they impact on for that product. The paper shows a practical example taken from a real product extension project where the methodology was used. Since the main inputs for product extensions usually come from the marketing department, it resulted to be very effective in broadening the perspective. Thus it ended up in a holistic list of requirements, covering the needs of all the Stakeholders. Requirements frame the development problem, hence, as more they are complete as less failure risks there are. The methodology requires further experiments in other industries to prove its generality. Nonetheless it is expected to provide great support in product extension activities by lowering failure risk and by helping in satisfying all the Stakeholder needs

Structured product development process implementation for a packaging company

This paper describes the analysis of a structured development process (SDP) that takes into account the particular specifications and requirements in the manufacture of packaging machines. The proposed approach is based on the well known "V-model" approach, which aims to support engineering teams in developing complex systems

Bone marrow derived stem cells for the treatment of end-stage liver disease

End-stage disease due to liver cirrhosis is an important cause of death worldwide. Cirrhosis results from progressive, extensive fibrosis and impaired hepatocyte regeneration. The only curative treatment is liver transplantation, but due to the several limitations of this procedure, the interest in alternative therapeutic strategies is increasing. In particular, the potential of bone marrow stem cell (BMSC) therapy in cirrhosis has been explored in different trials. In this article, we evaluate the results of 18 prospective clinical trials, and we provide a descriptive overview of recent advances in the research on hepatic regenerative medicine. The main message from the currently available data in the literature is that BMSC therapy is extremely promising in the context of liver cirrhosis. However, its application should be further explored in randomized, controlled trials with large cohorts and long follow-ups

Bone marrow derived stem cells for the treatment of end-stage liver disease.

End-stage disease due to liver cirrhosis is an important cause of death worldwide. Cirrhosis results from progressive, extensive fibrosis and impaired hepatocyte regeneration. The only curative treatment is liver transplantation, but due to the several limitations of this procedure, the interest in alternative therapeutic strategies is increasing. In particular, the potential of bone marrow stem cell (BMSC) therapy in cirrhosis has been explored in different trials. In this article, we evaluate the results of 18 prospective clinical trials, and we provide a descriptive overview of recent advances in the research on hepatic regenerative medicine. The main message from the currently available data in the literature is that BMSC therapy is extremely promising in the context of liver cirrhosis. However, its application should be further explored in randomized, controlled trials with large cohorts and long follow-ups

CD133+ hematopoietic stem cells reinfusion in end-stage liver disease (ESLD): final results of a phase I clinical trial

none13nononeC. Margini, L. Brodosi, S. Lorenzini, L. Catani, V. Giudice, R. Giordano, A. Casadei, D. Sollazzo, F.G. Foschi, M. Baccarani, M. Bernardi, R. Lemoli, P. AndreoneC. Margini, L. Brodosi, S. Lorenzini, L. Catani, V. Giudice, R. Giordano, A. Casadei, D. Sollazzo, F.G. Foschi, M. Baccarani, M. Bernardi, R. Lemoli, P. Andreon