Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar.

Multi-drug resistant falciparum malaria is widespread in Asia. In Thailand, Cambodia and Vietnam the national protocols have changed largely to artesunate combined treatment regimens but elsewhere in East and South Asia chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are still widely recommended by national malaria control programmes. In Kachin State, northern Myanmar, an area of low seasonal malaria transmission, the efficacy of CQ (25 mg base/kg) and SP (1.25/25 mg/kg), the nationally recommended treatments at the time, were compared with mefloquine alone (M; 15 mg base/kg) and mefloquine combined with artesunate (MA; 15:4 mg/kg). An open randomized controlled trial enrolled 316 patients with uncomplicated Plasmodium falciparum malaria, stratified prospectively into three age-groups. Early treatment failures (ETF) occurred in 41% (32/78) of CQ treated patients and in 24% of patients treated with SP (18/75). In young children the ETF rates were 87% after CQ and 35% after SP. Four children (two CQ, two SP) developed symptoms of cerebral malaria within 3 days after treatment. By day 42, failure rates (uncorrected for reinfections) had increased to 79% for CQ and 81% for SP. ETF rates were 2.5% after treatment with M and 3.9% after treatment with MA (P > 0.2). Overall uncorrected treatment failure rates at day 42 following M and MA were 23% and 21%, respectively. Chloroquine and SP are completely ineffective for the treatment of falciparum malaria in northern Myanmar. Mefloquine treatment is much more effective, but three day combination regimens with artesunate will be needed for optimum efficacy and protection against resistance

Local Spin-Gauge Symmetry of the Bose-Einstein Condensates in Atomic Gases

The Bose-Einstein condensates of alkali atomic gases are spinor fields with local ``spin-gauge" symmetry. This symmetry is manifested by a superfluid velocity ${\bf u}_{s}$ (or gauge field) generated by the Berry phase of the spin field. In ``static" traps, ${\bf u}_{s}$ splits the degeneracy of the harmonic energy levels, breaks the inversion symmetry of the vortex nucleation frequency ${\bf \Omega}_{c1}$, and can lead to {\em vortex ground states}. The inversion symmetry of ${\bf \Omega}_{c1}$, however, is not broken in ``dynamic" traps. Rotations of the atom cloud can be generated by adiabatic effects without physically rotating the entire trap.Comment: Typos in the previous version corrected, thanks to the careful reading of Daniel L. Cox. 13 pages + 2 Figures in uuencode + gzip for

Two-component Bose-Einstein Condensates with Large Number of Vortices

We consider the condensate wavefunction of a rapidly rotating two-component Bose gas with an equal number of particles in each component. If the interactions between like and unlike species are very similar (as occurs for two hyperfine states of $^{87}$Rb or $^{23}$Na) we find that the two components contain identical rectangular vortex lattices, where the unit cell has an aspect ratio of $\sqrt{3}$, and one lattice is displaced to the center of the unit cell of the other. Our results are based on an exact evaluation of the vortex lattice energy in the large angular momentum (or quantum Hall) regime.Comment: 4 pages, 2 figures, RevTe

Quantum Criticality of 1D Attractive Fermi Gas

We obtain an analytical equation of state for one-dimensional strongly attractive Fermi gas for all parameter regime in current experiments. From the equation of state we derive universal scaling functions that control whole thermodynamical properties in quantum critical regimes and illustrate physical origin of quantum criticality. It turns out that the critical properties of the system are described by these of free fermions and those of mixtures of fermions with mass $m$ and $2m$. We also show how these critical properties of bulk systems can be revealed from the density profile of trapped Fermi gas at finite temperatures and can be used to determine the T=0 phase boundaries without any arbitrariness.Comment: extended version, 9 pages, 7 eps figures, corrections of few typo

Stereotaxic gamma knife surgery in treatment of critically located pilocytic astrocytoma: preliminary result

BACKGROUND: Low-grade gliomas are uncommon primary brain tumors, located more often in the posterior fossa, optic pathway, and brain stem and less commonly in the cerebral hemispheres. CASE PRESENTATIONS: Two patients with diagnosed recurrent cystic pilocytic astrocytoma critically located within the brain (thalamic and brain stem) were treated with gamma knife surgery. Gamma knife surgery (GKS) did improve the patient's clinical condition very much which remained stable later on. Progressive reduction on the magnetic resonance imaging (MRI) studies of the solid part of the tumor and almost disappearance of the cystic component was achieved within the follow-up period of 36 months in the first case with the (thalamic located lesion) and 22 months in the second case with the (brain stem located lesion). CONCLUSION: Gamma knife surgery represents an alternate tool in the treatment of recurrent and/or small postoperative residual pilocytic astrocytoma especially if they are critically locate

First and Second Sound Modes of a Bose-Einstein Condensate in a Harmonic Trap

We have calculated the first and second sound modes of a dilute interacting Bose gas in a spherical trap for temperatures ($0.6<T/T_{c}<1.2$) and for systems with $10^4$ to $10^8$ particles. The second sound modes (which exist only below $T_{c}$) generally have a stronger temperature dependence than the first sound modes. The puzzling temperature variations of the sound modes near $T_{c}$ recently observed at JILA in systems with $10^3$ particles match surprisingly well with those of the first and second sound modes of much larger systems.Comment: a shorten version, more discussions are given on the nature of the second sound. A long footnote on the recent work of Zaremba, Griffin, and Nikuni (cond-mat/9705134) is added, the spectrum of the (\ell=1, n_2=0) mode is included in fig.

Development of a stochastic computational fluid dynamics approach for offshore wind farms

In this paper, a method for stochastic analysis of an offshore wind farm using computational fluid dynamics (CFD) is proposed. An existing offshore wind farm is modelled using a steady-state CFD solver at several deterministic input ranges and an approximation model is trained on the CFD results. The approximation model is then used in a Monte-Carlo analysis to build joint probability distributions for values of interest within the wind farm. The results are compared with real measurements obtained from the existing wind farm to quantify the accuracy of the predictions. It is shown that this method works well for the relatively simple problem considered in this study and has potential to be used in more complex situations where an existing analytical method is either insufficient or unable to make a good prediction

Design and Development of the Observation and Analysis of Smectic Islands in Space Experiment

The primary objective of Observation and Analysis of Smectic Islands in Space (OASIS) experiment is to exploit the unique characteristics of freely suspended liquid crystals in a microgravity environment to advance the understanding of fluid state physic

Fragmented and Single Condensate Ground States of Spin-1 Bose Gas

We show that the ground state of a spin-1 Bose gas with an antiferro- magnetic interaction is a fragmented condensate in uniform magnetic fields. The number fluctuations in each spin component change rapidly from being enormous (order $N$) to exceedingly small (order 1) as the magnetization of the system increases. A fragmented condensate can be turned into a single condensate state by magnetic field gradients. The conditions for existence and the method of detecting fragmented states are presented.Comment: 4 pages, no figure