1,377 research outputs found
An Investigation of GeoBase Mission Data Set Design, Implementation, and Usage within Air Force Civil Engineer Electrical and Utilities Work Centers
In 2001, the Office of the Civil Engineer, Installation and Logistics, Headquarters, United States Air Force, (ILE) identified Civil Engineer Squadrons as the central point of contact for all base-level mapping requirements/activities. In order to update mapping methods and procedures, ILE has put into place a program called GeoBase, which uses private sector Geographic Information Systems (GIS) technology as a foundation. In its current state, GeoBase uses the concept of a Common Installation Picture (CIP) to describe the goal of a consolidated visual that integrates the many layers of mapping information. The CIP visual is formed from a collection of data elements that are termed Mission Data Sets (MDS). There are varieties of MDS each of which contain data specific to a particular geospatial domain. The research uses a case study methodology to investigate how the MDS are designed, implemented, and used within four USAF Civil Engineer Squadron Electrical and Utilities Work Centers. The research findings indicate that MDS design and implementation processes vary across organizations; however, fundamental similarities do exist. At the same time, an evolution and maturation of these processes is evident. As for MDS usage within the Electrical and Utilities Work Centers, it was found that MDS usage is increasing; however, data quality is a limiting factor. Based on the research findings, recommendations are put forward for improving wing/base-level GeoBase program design, implementation, and usage
Onset of antisocial behavior, affiliation with deviant friends, and childhood maladjustment: A test of the childhood- and adolescent-onset models
Predictors and concurrent correlates of childhood-onset and adolescent-onset antisocial behavior were studied in a sample of 165 boys and 151 girls, followed from age 6 to age 15. An integrated general growth mixture model was used to determine the number and shape of developmental trajectories of antisocial behavior exhibited by boys and girls. Associations of these trajectories with trajectories of attention-deficit/hyperactivity (ADH) problems and deviant peer affiliation were examined. A childhood-onset, an adolescent-onset, and a low antisocial behavior trajectory were identified. A minority of the sample (11%), mostly males, followed the childhood-onset trajectory. This trajectory was predicted by prior membership in the high ADH trajectory in childhood. The adolescent-onset trajectory (46%) was associated with increases in friends' antisocial behavior but not with ADH problems. Most females (60%) followed the low antisocial trajectory. A substantial proportion of females, however, followed the childhood (5%) and adolescent-onset trajectories (35%). The male-female ratios in the childhood and adolescent-onset trajectories were similar. The results largely supported theories that distinguish between childhood and adolescent onsets of antisocial behavior, but they did not suggest that boys and girls differ in the age of onset of antisocial behavior. Ā© 2007 Cambridge University Press
Chaos, containment and change: responding to persistent offending by young people
This article reviews policy developments in Scotland concerning 'persistent young offenders' and then describes the design of a study intended to assist a local planning group in developing its response. The key findings of a review of casefiles of young people involved in persistent offending are reported. It emerges that youth crime and young people involved in offending are more complex and heterogeneous than is sometimes assumed. This, along with a review of some literature about desistance from offending, reaffirms the need for properly individualised interventions. Studies of 'desisters' suggest the centrality of effective and engaging working relationships in this process. However, these studies also re-assert the significance of the social contexts of workersā efforts to bring 'change' out of 'chaos'. We conclude therefore that the 'new correctionalism' must be tempered with appreciation of the social exclusion of young people who offend
Alcohol affects neuronal substrates of response inhibition but not of perceptual processing of stimuli signalling a stop response
Alcohol impairs inhibitory control, including the ability to terminate an initiated action. While there is increasing knowledge about neural mechanisms involved in response inhibition, the level at which alcohol impairs such mechanisms remains poorly understood. Thirty-nine healthy social drinkers received either 0.4g/kg or 0.8g/kg of alcohol, or placebo, and performed two variants of a Visual Stop-signal task during acquisition of functional magnetic resonance imaging (fMRI) data. The two task variants differed only in their instructions: in the classic variant (VSST), participants inhibited their response to a āGo-stimulusā when it was followed by a āStop-stimulusā. In the control variant (VSST_C), participants responded to the āGo-stimulusā even if it was followed by a āStop-stimulusā. Comparison of successful Stop-trials (Sstop)>Go, and unsuccessful Stop-trials (Ustop)>Sstop between the three beverage groups enabled the identification of alcohol effects on functional neural circuits supporting inhibitory behaviour and error processing. Alcohol impaired inhibitory control as measured by the Stop-signal reaction time, but did not affect other aspects of VSST performance, nor performance on the VSST_C. The low alcohol dose evoked changes in neural activity within prefrontal, temporal, occipital and motor cortices. The high alcohol dose evoked changes in activity in areas affected by the low dose but importantly induced changes in activity within subcortical centres including the globus pallidus and thalamus. Alcohol did not affect neural correlates of perceptual processing of infrequent cues, as revealed by conjunction analyses of VSST and VSST_C tasks. Alcohol ingestion compromises the inhibitory control of action by modulating cortical regions supporting attentional, sensorimotor and action-planning processes. At higher doses the impact of alcohol also extends to affect subcortical nodes of fronto-basal ganglia- thalamo-cortical motor circuits. In contrast, alcohol appears to have little impact on the early visual processing of infrequent perceptual cues. These observations clarify clinically-important effects of alcohol on behaviour
The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice.
RATIONALE
Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice.
OBJECTIVE
We test the ability of GSK1521498 to reduce alcohol consumption and compare its intrinsic efficacy to that of naltrexone by comparing the two drugs at doses matched for equivalent receptor occupancy.
METHODS
Thirty-six C57BL/6J mice were tested in a DID procedure. In 2-day cycles, animals experienced one baseline, injection-free session, and one test session when they received two injections, one of test drug and one placebo. All animals received GSK1521498 (0, 0.1, 1 and 3Ā mg/kg, i.p., 30Ā min pre-treatment) and naltrexone (0, 0.1, 1 and 3Ā mg/kg, s.c. 10Ā min pre-treatment) in a cross-over design. Receptor occupancies following the same doses were determined ex vivo in separate groups by autoradiography, using [3H]DAMGO. Binding in the region of interest was measured integrally by computer-assisted microdensitometry and corrected for non-specific binding.
RESULTS
Both GSK1521498 and naltrexone dose-dependently decreased ethanol consumption. When drug doses were matched for 70-75Ā % receptor occupancy, GSK1521498 3Ā mg/kg, i.p., caused a 2.5-fold greater reduction in alcohol consumption than naltrexone 0.1Ā mg/kg, s.c. Both GSK1521498 and naltrexone significantly reduced sucrose consumption at a dose of 1Ā mg/kg but not 0.1Ā mg/kg. In a test of conditioned taste aversion, GSK1521498 (3Ā mg/kg) reduced sucrose consumption 24Ā h following exposure to a conditioning injection.
CONCLUSIONS
Both opioid receptor antagonists reduced alcohol consumption but GK1521498 has higher intrinsic efficacy than naltrexone
Which executive functioning deficits are associated with AD/HD, ODD/CD and comorbid AD/HD+ODD/CD?
Item does not contain fulltextThis study investigated (1) whether attention deficit/hyperactivity disorder (AD/HD) is associated with executive functioning (EF) deficits while controlling for oppositional defiant disorder/conduct disorder (ODD/CD), (2) whether ODD/CD is associated with EF deficits while controlling for AD/HD, and (3)~whether a combination of AD/HD and ODD/CD is associated with EF deficits (and the possibility that there is no association between EF deficits and AD/HD or ODD/CD in isolation). Subjects were 99~children ages 6ā12 years. Three putative domains of EF were investigated using well-validated tests: verbal fluency, working memory, and planning. Independent of ODD/CD, AD/HD was associated with deficits in planning and working memory, but not in verbal fluency. Only teacher rated AD/HD, but not parent rated AD/HD, significantly contributed to the prediction of EF task performance. No EF deficits were associated with ODD/CD. The presence of comorbid AD/HD accounts for the EF deficits in children with comorbid AD/HD+ODD/CD. These results suggest that EF deficits are unique to AD/HD and support the model proposed by R. A. Barkley (1997).17 p
Climate change adaptation in European river basins
This paper contains an assessment and standardized comparative analysis of the current water management regimes in four case-studies in three European river basins: the Hungarian part of the Upper Tisza, the Ukrainian part of the Upper Tisza (also called Zacarpathian Tisza), Alentejo Region (including the Alqueva Reservoir) in the Lower Guadiana in Portugal, and Rivierenland in the Netherlands. The analysis comprises several regime elements considered to be important in adaptive and integrated water management: agency, awareness raising and education, type of governance and cooperation structures, information management andāexchange, policy development andāimplementation, risk management, and finances and cost recovery. This comparative analysis has an explorative character intended to identify general patterns in adaptive and integrated water management and to determine its role in coping with the impacts of climate change on floods and droughts. The results show that there is a strong interdependence of the elements within a water management regime, and as such this interdependence is a stabilizing factor in current management regimes. For example, this research provides evidence that a lack of joint/participative knowledge is an important obstacle for cooperation, or vice versa. We argue that there is a two-way relationship between information management and collaboration. Moreover, this research suggests that bottom-up governance is not a straightforward solution to water management problems in large-scale, complex, multiple-use systems, such as river basins. Instead, all the regimes being analyzed are in a process of finding a balance between bottom-up and topādown governance. Finally, this research shows that in a basin where one type of extreme is dominantālike droughts in the Alentejo (Portugal) and floods in Rivierenland (Netherlands)āthe potential impacts of other extremes are somehow ignored or not perceived with the urgency they might deserv
Fluxional Ī·^3-Allyl Derivatives of ansa-Scandocenes and an ansa-Yttrocene. Measurements of the Barriers for the Ī·^3 to Ī·^1 Process as an Indicator of Olefin Binding Energy to d^0 Metallocenes
Variable-temperature ^1H NMR spectroscopy indicates fluxional behavior for a number of group 3 metallocene allyl complexes. Spectral simulations and line shape analyses for the variable-temperature spectra indicate an allyl rearrangement mechanism involving rate-determining carbonācarbon double-bond dissociation from the metal center, i.e. an Ī·^3 to Ī·^1 change in coordination. Activation barriers to olefin dissociation have been determined for (Ī·^5-C_5Me_5)_2Sc(Ī·^3-C^3H^5), meso-Me^2Si(Ī·^5-3-CMe^3-C_5H_3)_2Sc(Ī·^3-C_3H_5), meso-Me_2Si[Ī·^5-2,4-(CHMe_2)_2-C_5H_2]_2Sc(Ī·^3-C_3H_5), meso-Me_2Si{Ī·^5-3-[2-(2-Me)-adamantyl]-C_5H_3}_2Sc(Ī·^3-C_3H_5), meso-Me_2Si{Ī·^5-3-[2-(2-Me)-adamantyl]-C_5H_3}_2Y(Ī·^3-C_3H_5), rac-Me_2Si[Ī·^5-2,4-(CHMe_2)_2-C_5H_2]_2Sc(Ī·^3-C_3H_5)), and R-(C_(20)H_(12)O_2)Si(Ī·^5-2-SiMe_3-4-CMe_3-C_5H_2)_2Sc(Ī·^3-C_3H_5):ā ĪG^ā§§ = 11ā16 kcal mol^(-1) at ca. 300ā350 K. Donor solvents do not significantly affect the rate of olefin dissociation. A second rearrangement mechanism that involves 180Ā° rotation of the Ī·^3-C_3H_5 moiety has been found to operate in those metallocenes whose ancillary ligand arrays adopt rigid meso geometries. Line shape analysis indicates that the rate of Ī·^3-C_3H_5 rotation is generally more than 1 order of magnitude faster than olefin dissociation for a given meso metallocene. The data do not allow unambiguous assessments of the mechanism(s) for the fluxional behavior for the allyl derivatives of the racemic metallocenes. An X-ray structure determination for rac-Me_2Si[Ī·^5-C_5H_2-2,4-(CHMe_2)_2]_2Sc(Ī·^3-C_3H_5) has been carried out
Developmental links between trajectories of physical violence, vandalism, theft, and alcohol-drug use from childhood to adolescence
Differences in developmental trajectories of physical violence, vandalism, theft, and alcohol-drug use from ages 10 to 15 were studied. For females and for males, three trajectories of theft and of alcohol-drug use increased from 10 years to 15 years, while only the high trajectory of vandalism increased from ten to 14. All trajectories of physical violence decreased. Children who engaged in the high trajectories of vandalism, theft, and alcohol-drug use had a high probability of also being high in physical violence. Compared to males, females were less likely to be on the high trajectory of physical violence, and their trajectories of other antisocial behaviors were less strongly associated with high levels of physical violence. The results suggest that physical violence during pre-adolescence and adolescence has a different developmental pattern than other forms of antisocial behavior, and that its relation to these other forms of antisocial behavior differs by se
Factors influencing the prevalence of animal cruelty during adolescence
Adolescentsā interactions with animals are of increasing interest and their beneficial developmental outcomes are well known. However, negative interactions such as perpetrating cruelty toward animals during childhood and adolescence have been related with child abuse, domestic violence, and later interpersonal violence. Cruelty toward animals by adolescents has been reported predominately in criminal and clinical samples, and links have been made between animal cruelty and interpersonal violence. However, studies often lack a clear definition of animal cruelty and the animal involved. The present study addresses methodological shortcomings by providing a clear definition of the cruelty acts and the animals involved and the time frame within which cruelty acts have been taken place. Therefore, we investigated the prevalence of animal cruelty of 979 British adolescents (419 male, 497 female, Mage = 15.1 Ā± 1.57 years) by means of a survey questionnaire administered in school. Animal cruelty was investigated encompassing deliberate and nondeliberate cruelty acts, a clear definition of the target animals was included and a time frame was provided. Furthermore, acceptability of animal cruelty, engaging in antisocial behavior, and family affluence were investigated. Results show high reliabilities for the measures applied. Exploratory factor analysis reveals different types of animal cruelty. Gender differences were observed for deliberate and accidental cruelty acts, with boys reporting higher levels than girls. Younger adolescents reported higher accidental cruelty acts than older ones. Acceptance of animal cruelty played a significant role in predicting animal cruelty, together with antisocial behaviors and place of living. The present study shows for the first time the importance of distinguishing between different types of animal cruelty and defining the animals involved.PostprintPeer reviewe
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