380 research outputs found

    Impacts of energy legislation on organizational motivation: a case study

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    Also deposited at UCL Open Access system https://rps.ucl.ac.uk/viewobject.html?cid=1&id=1276948 The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link

    Research on the influence Integrated Marketing Communications at Enterprises business in the Republic of Serbia

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       The aim of this paper is to show the essence of integrated marketing communications, the basic advantages a strategic approach to the functioning of this concept in enterprises in the Republic of Serbia. On the basis of a set, a goal has been defined chosen access method and research on the basis of the sample of the use of techniques (methods) of the survey. The research was conducted through carefully structured questionnaires, appropriate choice questions, the correct formulation and their proper order, starting with the adopted principles usual practice, features examinee and the appointed goal. The results of the research indicate that the strategic approach to marketing communications, leading to a positive impact on business enterprises, but on the other hand, a large number of enterprises in Serbia are still more reliant on traditional forms of marketing communication. The obtained results show that the necessary investments in employees in terms of training and education so as to keep pace with time, track trends and introduce innovations in this field

    Magnetically altered ethanol fermentation capacity of Saccharomyces cerevisiae

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    We studied the effect of static magnetic fields on ethanol production by yeast Saccharomyces cerevisiae 424A (LNH-ST) using sugar cane molasses during the fermentation in an enclosed bioreactor. Two static NdFeB magnets were attached to a cylindrical tube reactor with their opposite poles (north to south), creating 150 mT magnetic field inside the reactor. Comparable differences emerged between the results of these two experimental conditions. We found ethanol productivity to be 15% higher in the samples exposed to 150 mT magnetic field

    IEEE Access Special Section Editorial: Recent Advances on Hybrid Complex Networks: Analysis and Control

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    Complex networks typically involve multiple disciplines due to network dynamics and their statistical nature. When modeling practical networks, both impulsive effects and logical dynamics have recently attracted increasing attention. Hence, it is of interest and importance to consider hybrid complex networks with impulsive effects and logical dynamics. Relevant research is prevalent in cells, ecology, social systems, and communication engineering. In hybrid complex networks, numerous nodes are coupled through networks and their properties usually lead to complex dynamic behaviors, including discrete and continuous dynamics with finite values of time and state space. Generally, continuous and discrete sections of the systems are described by differential and difference equations, respectively. Logical networks are used to model the systems where time and state space take finite values. Although interesting results have been reported regarding hybrid complex networks, the analysis methods and relevant results could be further improved with respect to conservative impulsive delay inequalities and reproducibility of corresponding stability or synchronization criteria. Therefore, it is necessary to devise effective approaches to improve the analysis method and results dealing with hybrid complex networks

    Acute onset of tinnitus in patients with sudden deafness

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    Objective: We made hypotheses that tinnitus will appear more likely in patients with sudden deafness with superior hearing in unaffected ear or with more severe acute hearing loss. Methods: A retrospective cohort study was performed. Five hundred forty-one patients were identified with idiopathic sudden sensorineural hearing loss (ISSHL) from January 1995 to August 2006. The exclusion criteria for this study were as follows: bilateral sudden hearing loss and Meniere disease, previous tinnitus or bilateral tinnitus at initial evaluation, and onset of hearing loss less than 7 days. The cohort enrolled 454 patients. The enrolled patients were classified into two groups: patient with acute onset tinnitus in the affected ear and patients without tinnitus at initial visit. Main outcome measures were patient age, the presence or absence of vertigo and tinnitus, audiometric patterns, the severity of hearing loss, and hearing in the unaffected ear. Results: Better contralateral hearing (n = 220 versus n = 72, P < 0.001) and younger age (48 versus 55 years, P < 0.001) were independently associated with the acute onset of tinnitus in patients with ISSHL. The degree of asymmetry between the ears did not differ significantly between patients with and without tinnitus. The sex, presence of vertigo, shape of audiogram, and severity of hearing loss were not correlated with tinnitus occurrence. Conclusions: Tinnitus triggered by ISSHL was more frequent in patients with better contralateral hearing and of a younger age, irrespective of the severity of hearing loss on the affected side or the asymmetry between the ears

    Cell-Autonomous Death of Cerebellar Purkinje Neurons with Autophagy in Niemann-Pick Type C Disease

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    Niemann-Pick type C is a neurodegenerative lysosomal storage disorder caused by mutations in either of two genes, npc1 and npc2. Cells lacking Npc1, which is a transmembrane protein related to the Hedgehog receptor Patched, or Npc2, which is a secreted cholesterol-binding protein, have aberrant organelle trafficking and accumulate large quantities of cholesterol and other lipids. Though the Npc proteins are produced by all cells, cerebellar Purkinje neurons are especially sensitive to loss of Npc function. Since Niemann-Pick type C disease involves circulating molecules such as sterols and steroids and a robust inflammatory response within the brain parenchyma, it is crucial to determine whether external factors affect the survival of Purkinje cells (PCs). We investigated the basis of neurodegeneration in chimeric mice that have functional npc1 in only some cells. Death of mutant npc1 cells was not prevented by neighboring wild-type cells, and wild-type PCs were not poisoned by surrounding mutant npc1 cells. PCs undergoing cell-autonomous degeneration have features consistent with autophagic cell death. Chimeric mice exhibited a remarkable delay and reduction of wasting and ataxia despite their substantial amount of mutant tissue and dying cells, revealing a robust mechanism that partially compensates for massive PC death
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