2,628 research outputs found

    An Exceptional Story

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    The temperature was more than 90 degrees Fahrenheit as I lay on my keister in the shade of an oak tree relaxing at the babbling weir of Anaheim Creek. My enjoyment was enhanced by several heirfers stopping to drink, and a skein of ducks flying at a considerable height above the forest. The event was a nonpareil leisure occurrence

    Ants Are All Over

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    This is a story of an enchanting young man, Anthony Santiago, an immigrant from Antwerp, who became a very important contributor to our society as a result of his penchant for inventions. He was responsible for the development. He created a safety lantern for use in anthracite mines, a sextant that received world-wide acclaim, and he helped perfect a disinfectant for commercial use

    Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability

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    Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability. Am J Physiol Renal Physiol 313: F174 –F183, 2017. First published March 29, 2017; doi:10.1152/ajprenal.00482.2016.—The goals of this study were to 1) develop a computational model of solute transport and oxygenation in the kidney of the female spontaneously hypertensive rat (SHR), and 2) apply that model to investigate sex differences in nitric oxide (NO) levels in SHR and their effects on medullary oxygenation and oxidative stress. To accomplish these goals, we first measured NO synthase (NOS) 1 and NOS3 protein expression levels in total renal microvessels of male and female SHR. We found that the expression of both NOS1 and NOS3 is higher in the renal vasculature of females compared with males. To predict the implications of that finding on medullary oxygenation and oxidative stress levels, we developed a detailed computational model of the female SHR kidney. The model was based on a published male kidney model and represents solute transport and the biochemical reactions among O2, NO, and superoxide (O2 ) in the renal medulla. Model simulations conducted using both male and female SHR kidney models predicted significant radial gradients in interstitial fluid oxygen tension (PO2) and NO and O2 concentration in the outer medulla and upper inner medulla. The models also predicted that increases in endothelial NO-generating capacity, even when limited to specific vascular segments, may substantially raise medullary NO and PO2 levels. Other potential sex differences in SHR, including O2 production rate, are predicted to significantly impact oxidative stress levels, but effects on NO concentration and PO2 are limited.This research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases Grant R01-DK-106102 to A. T. Layton, and by American Heart Association Grant 14GRNT20480199 to J. C. Sullivan. (R01-DK-106102 - National Institute of Diabetes and Digestive and Kidney Diseases; 14GRNT20480199 - American Heart Association)Accepted manuscrip

    The Phoenician Name KPR: Young Lion or He Forgives ? A Rejoinder.

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    Spectral scaling of the Leray-α\alpha model for two-dimensional turbulence

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    We present data from high-resolution numerical simulations of the Navier-Stokes-α\alpha and the Leray-α\alpha models for two-dimensional turbulence. It was shown previously (Lunasin et al., J. Turbulence, 8, (2007), 751-778), that for wavenumbers kk such that kα≫1k\alpha\gg 1, the energy spectrum of the smoothed velocity field for the two-dimensional Navier-Stokes-α\alpha (NS-α\alpha) model scales as k−7k^{-7}. This result is in agreement with the scaling deduced by dimensional analysis of the flux of the conserved enstrophy using its characteristic time scale. We therefore hypothesize that the spectral scaling of any α\alpha-model in the sub-α\alpha spatial scales must depend only on the characteristic time scale and dynamics of the dominant cascading quantity in that regime of scales. The data presented here, from simulations of the two-dimensional Leray-α\alpha model, confirm our hypothesis. We show that for kα≫1k\alpha\gg 1, the energy spectrum for the two-dimensional Leray-α\alpha scales as k−5k^{-5}, as expected by the characteristic time scale for the flux of the conserved enstrophy of the Leray-α\alpha model. These results lead to our conclusion that the dominant directly cascading quantity of the model equations must determine the scaling of the energy spectrum.Comment: 11 pages, 4 figure

    A note on the rising cost of education in Australia

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    Human capital, or a better educated labour force, is a major determinant of economic growth and productivity. However, recent trends in the cost of education in Australia may cause growth and productivity to suffer. For example, during the period 1982-2003 inflation rose on average by 4.4 per cent per annum, whereas the cost of education grew overall on average by 7.8 per cent. This has made education a relatively expensive item among Australian households. This paper compares and contrasts the cost of education in Australia and comparable economies with the cost of other goods and services embedded in the CPI (Consumer Price Index) basket using the latest available quarterly data. Finally, the major determinants of the rising cost of education in Australia are examined. It is found, inter alia, that over the period 1986-2003 the increasing number of students enrolled at non-governmental primary and secondary schools and the introduction of the Higher Education Contribution Scheme (HECS) were two important determinants of the rising cost of education
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