The Use of Cafeteria Trials for the Selection of \u3ci\u3eDesmodium ovalifolium\u3c/i\u3e Genotypes

For the selection of tropical legumes which contain anti-nutritive components such as tannins, relative acceptability of genotypes to ruminants is of particular importance, since these plant components may influence selective grazing behaviour and subsequent animal productivity. Plant-animal interactions are not predictable from laboratory analyses. Involving grazing animals through the conduction of relative-acceptability (=cafeteria) trials at early stages of the germplasm selection process might therefore provide a convenient tool to adjust and confirm genotype selection based on laboratory quality analyses data. As part of a multilocational germplasm evaluation project, cafeteria-experiments were conducted at two contrasting environments in Colombia with a core collection of Desmodium ovalifolium, a tropical legume species containing tannins. The objective of these experiments was to assess the usefulness of such acceptability trials in the selection of D. ovalifolium genotypes. Relative acceptability indices for the 18 accessions confirm genotype selection based on a series of laboratory quality analyses during earlier stages of the project and indicate pronounced genotype-environment interactions. Moreover, animal activity profiles confirm the influence of plant-environment-animal interactions and thus the usefulness of cafeteriatrials for germplasm selection projects

Influence of mental health literacy on help-seeking behaviour for mental health problems in the Swiss young adult community: a cohort and longitudinal case–control study

Poor knowledge about mental health disorders and their treatment likely contributes to the large treatment gap reported for mental health problems. Therefore, we studied the association between mental health literacy (MHL) and active help-seeking in a community sample. Participants were recruited from an add-on questionnaire study to the 'Bern Epidemiological At-Risk' (BEAR) study on 16-40-year-old community subjects of the Swiss canton Bern. At baseline, data of N = 1504, and at 3-year follow-up, data of N = 535 were available. Based on an unlabelled case vignette (on depression or schizophrenia), MHL was assessed by the questionnaire of Angermeyer and colleagues. Cross-sectional and longitudinal baseline predictors of help-seeking were analysed using path analyses. Additionally, sensitivity analyses of the prospective model were computed for sex, vignette, and baseline mental health problems/disorders. Cross-sectionally, help-seeking was associated with non-endorsement of biogenetic causal explanations, presence of mental health problems/disorders, help-seeking before baseline, poorer functioning, and lower health satisfaction. The prospective model was similar; yet, help-seeking at follow-up was associated with endorsements of the causal explanation 'biogenetics' and, additionally, 'childhood trauma' but not the presence of baseline mental health problems/disorders. Sensitivity analyses revealed a significant impact on sex, vignette, and mental health problems/disorders. For example, actual functional problems were predictive in males, while health satisfaction was predictive in females. Our findings indicate that future studies on drivers of help-seeking should assess very large community samples with case vignettes on different mental disorders to examine appropriate subgroups and their likely interaction to address group-specific factors in awareness campaigns

How a spin-glass remembers. Memory and rejuvenation from intermittency data: an analysis of temperature shifts

The memory and rejuvenation aspects of intermittent heat transport are explored theoretically and by numerical simulation for Ising spin glasses with short-ranged interactions. The theoretical part develops a picture of non-equilibrium glassy dynamics recently introduced by the authors. Invoking the concept of marginal stability, this theory links irreversible `intermittent' events, or `quakes' to thermal fluctuations of record magnitude. The pivotal idea is that the largest energy barrier $b(t_w,T)$ surmounted prior to $t_w$ by thermal fluctuations at temperature $T$ determines the rate $r_q \propto 1/t_w$ of the intermittent events occurring near $t_w$. The idea leads to a rate of intermittent events after a negative temperature shift given by $r_q \propto 1/t_w^{eff}$, where the `effective age' $t_w^{eff} \geq t_w$ has an algebraic dependence on $t_w$, whose exponent contains the temperatures before and after the shift. The analytical expression is verified by numerical simulations. Marginal stability suggests that a positive temperature shift $T \to T'$ could erase the memory of the barrier $b(t_w,T)$. The simulations show that the barrier $b(t_w,T') \geq b(t_w,T)$ controls the intermittent dynamics, whose rate is hence $r_q \propto 1/t_w$. Additional `rejuvenation' effects are also identified in the intermittency data for shifts of both signs.Comment: Revised introduction and discussion. Final version to appear in Journal of Statistical Mechanics: Theory and Experimen

Volumetric evaluation of CT images of adrenal glands in primary aldosteronism

Objectives: To investigate whether adrenal volumetry provides better agreement with adrenal vein sampling (AVS) than conventional CT for subtyping PA. Furthermore, we evaluated whether the size of this contralateral adrenal was a prognostic factor for clinical outcome after unilateral adrenalectomy.Methods: We retrospectively analyzed volumes of both adrenal glands of the 180 CT-scans (88/180 with unilateral and 92/180 with bilateral disease) of the patients with PA included in the SPARTACUS trial of which 85 also had undergone an AVS. In addition, we examined CT-scans of 20 healthy individuals to compare adrenal volumes with published normal values.Results: Adrenal volume was higher for the left than the right adrenal (mean and SD: 6.49 ± 2.77 ml versus 5.25 ± 1.87 ml for the right adrenal; p &lt; 0.001). Concordance between volumetry and AVS in subtyping was 58.8%, versus 51.8% between conventional CT results and AVS (p = NS). The volumes of the contralateral adrenals in the patients with unilateral disease (right 4.78 ± 1.37 ml; left 6.00 ± 2.73 ml) were higher than those of healthy controls reported in the literature (right 3.62 ± 1.23 ml p &lt; 0.001; left 4.84 ± 1.67 ml p = 0.02). In a multivariable analysis the contralateral volume was not associated with biochemical or clinical success, nor with the defined daily doses of antihypertensive agents at 1 year follow-up.Conclusions: Volumetry of the adrenal glands is not superior to current assessment of adrenal size by CT for subtyping patients with PA. Furthermore, in patients with unilateral disease the size of the contralateral adrenal is enlarged but its size is not associated with outcome.</p

Legal issues in clouds: towards a risk inventory.

Cloud computing technologies have reached a high level of development, yet a number of obstacles still exist that must be overcome before widespread commercial adoption can become a reality. In a cloud environment, end users requesting services and cloud providers negotiate service-level agreements (SLAs) that provide explicit statements of all expectations and obligations of the participants. If cloud computing is to experience widespread commercial adoption, then incorporating risk assessment techniques is essential during SLA negotiation and service operation. This article focuses on the legal issues surrounding risk assessment in cloud computing. Specifically, it analyses risk regarding data protection and security, and presents the requirements of an inherent risk inventory. The usefulness of such a risk inventory is described in the context of the OPTIMIS project

The nucleotide and partial amino acid sequences of rat fetuin

Fetuins are among the major plasma proteins, yet their biological role has remained elusive. Here we report the molecular cloning of rat fetuin and the sequence analysis of a full-length clone, RF619 of 1456 bp with an open reading frame of 1056 bp encoding 352 amino acid residues. The coding part of RF619 was identical with the cDNA sequence of the natural inhibitor of the insulin receptor tyrosine kinase from rat (pp63) except for four substitutions and a single base insertion causing divergence of the predicted protein sequences. Partial amino acid sequences of rat plasma fetuin were in agreement with the predictions based on the RF619 cDNA. Purified rat fetuin inhibited the insulin receptor tyrosine kinase in vitro. Therefore, we conclude that RF619 and pp63 cDNA encode the same protein, i.e. authentic rat fetuin which is a functional tyrosine kinase inhibitor

Extraction of electromagnetic neutron form factors through inclusive and exclusive polarized electron scattering on polarized 3He target

Inclusive 3He(e,e') and exclusive 3He(e,e'n) processes with polarized electrons and 3He have been theoretically analyzed and values for the magnetic and electric neutron form factors have been extracted. In both cases the form factor values agree well with the ones extracted from processes on the deuteron. Our results are based on Faddeev solutions, modern NN forces and partially on the incorporation of mesonic exchange currents.Comment: 28 pages, 29 Postscript figure