Spiral model, jamming percolation and glass-jamming transitions

The Spiral Model (SM) corresponds to a new class of kinetically constrained models introduced in joint works with D.S. Fisher [8,9]. They provide the first example of finite dimensional models with an ideal glass-jamming transition. This is due to an underlying jamming percolation transition which has unconventional features: it is discontinuous (i.e. the percolating cluster is compact at the transition) and the typical size of the clusters diverges faster than any power law, leading to a Vogel-Fulcher-like divergence of the relaxation time. Here we present a detailed physical analysis of SM, see [5] for rigorous proofs. We also show that our arguments for SM does not need any modification contrary to recent claims of Jeng and Schwarz [10].Comment: 9 pages, 7 figures, proceedings for StatPhys2

Boundary conditions and defect lines in the Abelian sandpile model

We add a defect line of dissipation, or crack, to the Abelian sandpile model. We find that the defect line renormalizes to separate the two-dimensional plane into two half planes with open boundary conditions. We also show that varying the amount of dissipation at a boundary of the Abelian sandpile model does not affect the universality class of the boundary condition. We demonstrate that a universal coefficient associated with height probabilities near the defect can be used to classify boundary conditions.Comment: 8 pages, 1 figure; suggestions from referees incorporated; to be published in Phys. Rev.

The Dual-Phase Mechanism for the Catalytic Conversion of n-Butane to Maleic Anhydride by the Vanadyl Pyrophosphate Heterogeneous Catalyst

Industrial production of maleic anhydride (MA) from n-butane relies on the vanadyl pyrophosphate (VPO) catalyst. Improving VPO’s selectivity and activity could have enormous economic and environmental impact, but efforts have been impeded by uncertainties regarding the active phases and atomistic mechanism of the VPO catalyst. We report here a plausible 15-step mechanism taking n-butane to MA with energetics computed using hybrid density functional theory calculations on periodic models of the surface layers. We find that the P═O group on the X1 phase is solely responsible for butane activation. The P═O group is made active by the reduction of a nearby vanadium atom, a so-called reduction-coupled oxo-activation. However, we show that a catalyst consisting only of the X1 phase would not be selective because of several highly exothermic steps. Instead, we show that the more stable α1 phase can catalyze the formation of MA after initial activation, thus proposing and validating a dual-phase mechanism that takes butane to MA. Our new mechanism inspires the development of a more selective VPO catalyst containing small X1 regions highly separated by α_1 surfaces

Fiber Optic Tactical Local Network (FOTLAN)

A 100 Mbit/s FDDI (fiber distributed data interface) network interface unit is described that supports real-time data, voice and video. Its high-speed interrupt-driven hardware architecture efficiently manages stream and packet data transfer to the FDDI network. Other enhancements include modular single-mode laser-diode fiber optic links to maximize node spacing, optic bypass switches for increased fault tolerance, and a hardware performance monitor to gather real-time network diagnostics

New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity.

Interleukin-15 (IL-15) is a potent cytokine that increases CD8+ T and NK cell numbers and function in experimental models. However, obstacles remain in using IL-15 therapeutically, specifically its low potency and short in vivo half-life. To help overcome this, a new IL-15 superagonist complex comprised of an IL-15N72D mutation and IL-15RαSu/Fc fusion (IL-15SA, also known as ALT-803) was developed. IL-15SA exhibits a significantly longer serum half-life and increased in vivo activity against various tumors. Herein, we evaluated the effects of IL-15SA in recipients of allogeneic hematopoietic stem cell transplantation. Weekly administration of IL-15SA to transplant recipients significantly increased the number of CD8+ T cells (specifically CD44+ memory/activated phenotype) and NK cells. Intracellular IFN-γ and TNF-α secretion by CD8+ T cells increased in the IL-15SA-treated group. IL-15SA also upregulated NKG2D expression on CD8+ T cells. Moreover, IL-15SA enhanced proliferation and cytokine secretion of adoptively transferred CFSE-labeled T cells in syngeneic and allogeneic models by specifically stimulating the slowly proliferative and nonproliferative cells into actively proliferating cells.We then evaluated IL-15SA\u27s effects on anti-tumor activity against murine mastocytoma (P815) and murine B cell lymphoma (A20). IL-15SA enhanced graft-versus-tumor (GVT) activity in these tumors following T cell infusion. Interestingly, IL-15 SA administration provided GVT activity against A20 lymphoma cells in the murine donor leukocyte infusion (DLI) model without increasing graft versus host disease. In conclusion, IL-15SA could be a highly potent T- cell lymphoid growth factor and novel immunotherapeutic agent to complement stem cell transplantation and adoptive immunotherapy

Answer quality characteristics and prediction on an academic QandA site: A case study on researchgate

Despite various studies on examining and predicting answer quality on generic social QandA sites such as Yahoo! Answers, little is known about why answers on academic QandA sites are voted on by scholars who follow the discussion threads to be high quality answers. Using 1021 answers obtained from the QandA part of an academic social network site ResearchGate (RG), we firstly explored whether various web-captured features and human-coded features can be the critical factors that influence the peer-judged answer quality. Then using the identified critical features, we constructed three classification models to predict the peer-judged rating. Our results identify four main findings. Firstly, responders' authority, shorter response time and greater answer length are the critical features that positively associate with the peer-judged answer quality. Secondly, answers containing social elements are very likely to harm the peer-judged answer quality. Thirdly, an optimized SVM algorithm has an overwhelming advantage over other models in terms of accuracy. Finally, the prediction based on web-captured features had better performance when comparing to prediction on human-coded features. We hope that these interesting insights on ResearchGate's answer quality can help the further design of academic QandA sites