1,154 research outputs found
Optimizing the vertebrate vestibular semicircular canal: could we balance any better?
The fluid-filled semicircular canals (SCCs) of the vestibular system are used
by all vertebrates to sense angular rotation. Despite masses spanning seven
decades, all mammalian SCCs are nearly the same size. We propose that the SCC
represents a sensory organ that evolution has `optimally designed'. Four
geometric parameters are used to characterize the SCC, and `building materials'
of given physical properties are assumed. Identifying physical and
physiological constraints on SCC operation, we find that the most sensitive SCC
has dimensions consistent with available data.Comment: 4 pages, 3 figure
Sensory Measurements: Coordination and Standardization
Do sensory measurements deserve the label of “measurement”? We argue that they do. They fit with an epistemological view of measurement held in current philosophy of science, and they face the same kinds of epistemological challenges as physical measurements do: the problem of coordination and the problem of standardization. These problems are addressed through the process of “epistemic iteration,” for all measurements. We also argue for distinguishing the problem of standardization from the problem of coordination. To exemplify our claims, we draw on olfactory performance tests, especially studies linking olfactory decline to neurodegenerative disorders
Human Wavelength Discrimination of Monochromatic Light Explained by Optimal Wavelength Decoding of Light of Unknown Intensity
We show that human ability to discriminate the wavelength of monochromatic light
can be understood as maximum likelihood decoding of the cone absorptions, with a
signal processing efficiency that is independent of the wavelength. This work is
built on the framework of ideal observer analysis of visual discrimination used
in many previous works. A distinctive aspect of our work is that we highlight a
perceptual confound that observers should confuse a change in input light
wavelength with a change in input intensity. Hence a simple ideal observer model
which assumes that an observer has a full knowledge of input intensity should
over-estimate human ability in discriminating wavelengths of two inputs of
unequal intensity. This confound also makes it difficult to consistently measure
human ability in wavelength discrimination by asking observers to distinguish
two input colors while matching their brightness. We argue that the best
experimental method for reliable measurement of discrimination thresholds is the
one of Pokorny and Smith, in which observers only need to distinguish two
inputs, regardless of whether they differ in hue or brightness. We
mathematically formulate wavelength discrimination under this
wavelength-intensity confound and show a good agreement between our theoretical
prediction and the behavioral data. Our analysis explains why the discrimination
threshold varies with the input wavelength, and shows how sensitively the
threshold depends on the relative densities of the three types of cones in the
retina (and in particular predict discriminations in dichromats). Our
mathematical formulation and solution can be applied to general problems of
sensory discrimination when there is a perceptual confound from other sensory
feature dimensions
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A high-resolution map of human evolutionary constraint using 29 mammals.
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering ∼4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for ∼60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease
A Positive Feedback Synapse from Retinal Horizontal Cells to Cone Photoreceptors
Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that
underlies lateral inhibition and establishes the antagonistic center-surround
organization of the visual system. Cones transmit to HCs through an excitatory
synapse and HCs feed back to cones through an inhibitory synapse. Here we report
that HCs also transmit to cone terminals a positive feedback signal that
elevates intracellular Ca2+ and accelerates neurotransmitter
release. Positive and negative feedback are both initiated by AMPA receptors on
HCs, but positive feedback appears to be mediated by a change in HC
Ca2+, whereas negative feedback is mediated by a change in
HC membrane potential. Local uncaging of AMPA receptor agonists suggests that
positive feedback is spatially constrained to active HC-cone synapses, whereas
the negative feedback signal spreads through HCs to affect release from
surrounding cones. By locally offsetting the effects of negative feedback,
positive feedback may amplify photoreceptor synaptic release without sacrificing
HC-mediated contrast enhancement
Adaptation of pineal expressed teleost exo-rod opsin to non-image forming photoreception through enhanced Meta II decay
Photoreception by vertebrates enables both image-forming vision and non-image-forming responses such as circadian photoentrainment. Over the recent years, distinct non-rod non-cone photopigments have been found to support circadian photoreception in diverse species. By allowing specialization to this sensory task a selective advantage is implied, but the nature of that specialization remains elusive. We have used the presence of distinct rod opsin genes specialized to either image-forming (retinal rod opsin) or non-image-forming (pineal exo-rod opsin) photoreception in ray-finned fish (Actinopterygii) to gain a unique insight into this problem. A comparison of biochemical features for these paralogous opsins in two model teleosts, Fugu pufferfish (Takifugu rubripes) and zebrafish (Danio rerio), reveals striking differences. While spectral sensitivity is largely unaltered by specialization to the pineal environment, in other aspects exo-rod opsins exhibit a behavior that is quite distinct from the cardinal features of the rod opsin family. While they display a similar thermal stability, they show a greater than tenfold reduction in the lifetime of the signaling active Meta II photoproduct. We show that these features reflect structural changes in retinal association domains of helices 3 and 5 but, interestingly, not at either of the two residues known to define these characteristics in cone opsins. Our findings suggest that the requirements of non-image-forming photoreception have lead exo-rod opsin to adopt a characteristic that seemingly favors efficient bleach recovery but not at the expense of absolute sensitivity
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Configuration control, fluctuations, and transport in low-collisionality plasmas in the ATF Torsatron
In low-collisionality plasmas confined in tokamaks and stellarators, instabilities driven by particles trapped in inhomogeneities of the magnetic fields could be important in increasing plasma transport coefficients. In the Advanced Toroidal Facility (ATF), an {ell} = 2, M = 12 field-period stellarator device with major radius R = 2.1 m, average plasma minor radius a = 0.27 m, central and edge rotational transforms {chi}{sub 0} {approx} 0.3, {chi}{sub a} {approx} 1, the effects of electron trapping in the helical stellarator field are expected to be important in plasmas with {bar n}{sub e} {approx} 5 {times} 10{sup 12} cm{sup {minus}3}, T{sub e0} {approx} 1 keV. Such plasmas have already been sustained for long-pulses (20 s) using 150--400 kW of 53.2-GHz ECH power at B = 0.95 T. Transport analysis shows that for {rho} = r/a {le} 1/3, the electron anomalous transport is {le}10 times the neoclassical value, while at {rho} = 2/3 it is 10--100 times neoclassical; this is compatible with expectations for transport enhancement due to dissipative trapped-electron modes. 4 refs., 3 figs
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