37 research outputs found
h-deformation of Gr(2)
The -deformation of functions on the Grassmann matrix group is
presented via a contraction of . As an interesting point, we have seen
that, in the case of the -deformation, both R-matrices of and
are the same
Towards an ecology of collective innovation: Human variome project (HVP), rare disease consortium for autosomal loci (RADical) and data-enabled life sciences alliance (DELSA)
Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines
International audienceThe phytochemical resveratrol, found in grapes, berries and peanuts, has been found to possess cancer chemopreventive effects by inhibiting diverse cellular events associated with tumour initiation, promotion and progression. Resveratrol is also a phyto-oestrogen, binds to and activates oestrogen receptors that regulate the transcription of oestrogen-responsive target genes such as the breast cancer susceptibility genes BRCA1 and BRCA2. We investigated the effects of resveratrol on BRCA1 and BRCA2 expression in human breast cancer cell lines (MCF7, HBL 100 and MDA-MB 231) using quantitative real-time RT-PCR, and by perfusion chromatography of the proteins. All cell lines were treated with 30 microM resveratrol. The expressions of BRCA1 and BRCA2 mRNAs were increased although no change in the expression of the proteins were found. These data indicate that resveratrol at 30 micro M can increase expression of genes involved in the aggressiveness of human breast tumour cell lines
Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review
Toy M, Önder FO, Wörmann T, et al. Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review. BMC infectious diseases. 2011;11(1): 337.BACKGROUND: To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey. METHODS: A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence. RESULTS: The estimated overall population prevalence was 4.57, 95% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95% CI: 2.60, 3.10) for the 0-14-year olds to 6.36 (95% CI: 5.83, 6.90) in the 25-34-year-old group. CONCLUSION: There are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem
Resposta de testes de hipersensibilidade tardia utilizando PPD e outros antígenos em crianças e adolescentes saudáveis e infectados pelo HIV-1 e vacinados com BCG
International nosocomial infection control consortium (INICC) report, data summary of 36 countries, for 2004-2009
The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia). Copyright © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved
Çocuklarda beslenme ve kurşun etkileşimi
Lead is a commonly found environmental toxic element that deteriorates health, especially that of children. Sixteen percent of daily intake of lead comes from foods, and 40% of that is due to adherence of dust on surfaces of foods during preparation. Low socioeconomical level and long-term malnutrition are the most important risk factors for lead contact in infant feeding. Decrease in calcium, iron, zinc and protein in the diet increases the gastrointestinal absorption of lead. Lead absorption can be decreased in children by adequate intake of calcium. Lead level in breast-milk is about ten percent of the blood lead level and it shows correlation with the blood lead level of the mother. Lead level in breast-milk of smoking mothers is twice that of non-smoking mothers. In order to decrease lead absorption, children should be fed with a diet rich in vitamin and minerals without skipping meals; milk and milk products enriched with calcium should be present in the diet and adequate iron should be included in the diet. It is necessary to follow-up the children at risk periodically and monitor blood lead levels regularly in order to develop early prevention strategies against lead intoxication
Traditional beliefs as forgotten influencing factors on breast-feeding performance in Turkey
Ceyhun Peker, A. Gulsen/0000-0002-0856-9790WOS: 000237162700014PubMed: 16598330Objectives: The aim of this cross-sectional study was to identify the infant feeding practices and to evaluate the attitudes and beliefs of mothers on breast-feeding in Turkey. Methods: This study was established in 10 provinces of Turkey between December 2000 and March 2001 and the study group was comprised of 1,767 women between the ages of 15-49 years (mean 27.6 +/- 6.4 years). Questionnaires were self-filled by mothers in the waiting rooms of the health centers. Results: One hundred seventy-three women (9.9%) were illiterate, 829 (47.7%) had <= 5 years of schooling, and 83.4% were housewives. A significant number of women have traditional beliefs related to breast-feeding practices. According to 23.4% of the women at least 3 calls to prayer (average 12 hours) should be waited before the first breast-feeding postpartum and more than 30% of the mothers believe that colostrum should not be given to the newborn, some mothers' breast milk could harm their babies, and an evil eye could harm their breast milk. The traditional belief status and educational status of the women differed significantly between provinces, lower educational status and higher rates of women with traditional beliefs were observed in less developed eastern provinces. Overall, 60.6% of the women were knowledgeable on breast-feeding practices, whereas only 13.5% were scored as good in attitudes. Among all women with breast-feed babies, 35.8% started supplementary feeding in the first 3 months of life. Mother's age, education, occupation and traditional beliefs did not have a significant effect on supplementation time. Conclusions: As a result, these findings suggest the importance of taking into account the customs, local beliefs and family influences in planning community health programs
Kırıkkale'de ilköğretimde okuyan çocuklarda kan kurşun düzeyleri
The aim of this study was to a determine the relation of blood lead levels socio-economical and nutrition status in primary school children in Kirikkale. Socio-economical and demographical information and blood were obtained. For the 533 children (7-16 years old) from four primary schools which were selected according to their distance from the factories which use lead. The mean blood lead levels of the children were found to be 2.54 ±1.44 ?g/dl (min 0 - max 6.5 ?g/dl). The mean blood lead levels in the schools close to the high-risk area were higher than those observed in the distant schools. It was observed that as the extent of malnutrition increased, the blood lead levels decreased. No significant relation was found between blood lead levels and socioeconomical status. The blood lead levels of the children in Kirikkale are within the accepted range considered to be normal. Children residing closer to the industrial areas are exposed to more lead more and therefore they should be followed up more closely and regularly
Plasma free carnitine levels in 0-12-month-old infants in relation to feeding styles
PubMed: 17048190This study was planned to determine the blood carnitine levels of children aged 0-1 year in Kirikkale. Blood samples were taken on Guthrie cards and plasma free carnitine levels were analyzed by tandem mass specteometry. The mean free carnitine level was 25.12 ± 10.1 ?mol/L (10.1-49.5 ?mol/L). To assess the plasma free carnitine levels according to feeding style, babies were grouped as exclusively breastfed (n = 67, 49.3%), artificially fed (n = 24, 17.7%), and mixed fed (n = 45, 33%). The exclusively breastfed infants displayed the lowest free carnitine levels (p < 0.05). However, when this was analyzed in accordance with age, no significant change was observed in plasma free carnitine levels according to feeding style. Results of this study are important as they reveal an indication about the normal values of plasma free carnitine in Turkish infants and their relationship to feeding styles. © Hogrefe & Huber Publishers