Are Compact High-Velocity Clouds Extragalactic Objects?

Compact high-velocity clouds (CHVCs) are the most distant of the HVCs in the Local Group model and would have HI volume densities of order 0.0003/cm^3. Clouds with these volume densities and the observed neutral hydrogen column densities will be largely ionized, even if exposed only to the extragalactic ionizing radiation field. Here we examine the implications of this process for models of CHVCs. We have modeled the ionization structure of spherical clouds (with and without dark matter halos) for a large range of densities and sizes, appropriate to CHVCs over the range of suggested distances, exposed to the extragalactic ionizing photon flux. Constant-density cloud models in which the CHVCs are at Local Group distances have total (ionized plus neutral) gas masses roughly 20-30 times larger than the neutral gas masses, implying that the gas mass alone of the observed population of CHVCs is about 40 billion solar masses. With a realistic (10:1) dark matter to gas mass ratio, the total mass in such CHVCs is a significant fraction of the dynamical mass of the Local Group, and their line widths would exceed the observed FWHM. Models with dark matter halos fare even more poorly; they must lie within approximately 200 kpc of the Galaxy. We show that exponential neutral hydrogen column density profiles are a natural consequence of an external source of ionizing photons, and argue that these profiles cannot be used to derive model-independent distances to the CHVCs. These results argue strongly that the CHVCs are not cosmological objects, and are instead associated with the Galactic halo.Comment: 30 pages, 14 figures; to appear in The Astrophysical Journa

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.

Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon presentation. Silencing of EWS/FLI in patient-derived tumor cells results in the altered expression of hundreds to thousands of genes and is accompanied by dramatic morphological changes in cytoarchitecture and adhesion. Genes encoding focal adhesion, extracellular matrix, and actin regulatory proteins are dominant targets of EWS/FLI-mediated transcriptional repression. Reexpression of genes encoding just two of these proteins, zyxin and α5 integrin, is sufficient to restore cell adhesion and actin cytoskeletal integrity comparable to what is observed when the EWS/FLI oncogene expression is compromised. Using an orthotopic xenograft model, we show that EWS/FLI-induced repression of α5 integrin and zyxin expression promotes tumor progression by supporting anchorage-independent cell growth. This selective advantage is paired with a tradeoff in which metastatic lung colonization is compromised

Observation of playa salts as nuclei in orographic wave clouds

During the Ice in Clouds Experiment-Layer Clouds (ICE-L), dry lakebed, or playa, salts from the Great Basin region of the United States were observed as cloud nuclei in orographic wave clouds over Wyoming. Using a counterflow virtual impactor in series with a single-particle mass spectrometer, sodium-potassium-magnesium-calcium-chloride salts were identified as residues of cloud droplets. Importantly, these salts produced similar mass spectral signatures to playa salts with elevated cloud condensation nuclei (CCN) efficiencies close to sea salt. Using a suite of chemical characterization instrumentation, the playa salts were observed to be internally mixed with oxidized organics, presumably produced by cloud processing, as well as carbonate. These salt particles were enriched as residues of large droplets (>19 μm) compared to smaller droplets (>7 μm). In addition, a small fraction of silicate-containing playa salts were hypothesized to be important in the observed heterogeneous ice nucleation processes. While the high CCN activity of sea salt has been demonstrated to play an important role in cloud formation in marine environments, this study provides direct evidence of the importance of playa salts in cloud formation in continental North America has not been shown previously. Studies are needed to model and quantify the impact of playas on climate globally, particularly because of the abundance of playas and expected increases in the frequency and intensity of dust storms in the future due to climate and land use changes

Charge distribution and electroluminescence in cross-linked polyethylene under dc field

The intent of this paper is to cross-correlate the information obtained by space charge distribution analysis and electroluminescence (EL) detection in cross-linked polyethylene samples submitted to dc fields, with the objective to make a link between space charge phenomena and energy release as revealed by the detection of visible photons. Space charge measurements carried out at different field levels by the pulsed electro-acoustic method show the presence of a low-field threshold, close to 15-20 kV mm-1, above which considerable space charge begins to accumulate in the insulation. Charges are seen to cross the insulation thickness through a packet-like behaviour at higher fields, starting at about 60-70 kV mm-1. EL measurements show the existence of two distinct thresholds, one related to the continuous excitation of EL under voltage, the other being transient EL detected upon specimen short circuit. The former occurs at values of field corresponding to charge packet formation and the latter to the onset of space charge accumulation. The correspondence between pertinent values of the electric field obtained through space charge and EL analyses provides support for the existence of degradation thresholds in insulating materials. Special emphasis is given to the relationship between charge packet formation and propagation, and EL. Although the two phenomena are observed in the same field range, it is found that the onset of continuous EL follows the formation at the electrodes of positive and negative space charge regions that extend into the bulk prior to the propagation of charge packets. Charge recombination appears to be the excitation process of EL since oppositely charged domains meet in the material bulk. To gain an insight into specific light-excitation processes associated with charge packet propagation, EL has been recorded for several hours under fields at which charge packet dynamics were evidenced. It is shown that current and luminescence oscillations are detected during charge packet propagation, and that they are in phase. The mechanisms underlying EL and charge packets are further considered on the basis of these results

Pauli Exchange Errors in Quantum Computation

In many physically realistic models of quantum computation, Pauli exchange interactions cause a subset of two-qubit errors to occur as a first order effect of couplings within the computer, even in the absence of interactions with the computer's environment. We give an explicit 9-qubit code that corrects both Pauli exchange errors and all one-qubit errors.Comment: Final version accepted for publication in Phys. Rev. Let

Translating Research Into Practice: Speeding the Adoption of Innovative Health Care Programs

Looks at case studies of four innovative clinical programs to determine key factors influencing the diffusion and adoption of innovations in health care

Nonlinear Competition Between Small and Large Hexagonal Patterns

Recent experiments by Kudrolli, Pier and Gollub on surface waves, parametrically excited by two-frequency forcing, show a transition from a small hexagonal standing wave pattern to a triangular ``superlattice'' pattern. We show that generically the hexagons and the superlattice wave patterns bifurcate simultaneously from the flat surface state as the forcing amplitude is increased, and that the experimentally-observed transition can be described by considering a low-dimensional bifurcation problem. A number of predictions come out of this general analysis.Comment: 4 pages, RevTex, revised, to appear in Phys. Rev. Let

Pediatric Transplantation in the United States, 1995–2004

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72899/1/j.1600-6143.2006.01271.x.pd

Life, Life Support, and Death Principles, Guidelines, Policies and Procedures for Making Decisions That Respect Life

The following is the third edition of a booklet by the American Life League, Inc. The section on Ordinary/Extraordinary Means has been revised. The sections on Quality of Life, Pain, Paired Organ and Non-vital Organ and Tissue Transplant, and Determination of Death have been added. There are other changes throughout the booklet