378 research outputs found
Nutrients and pathways that regulate health span and life span
Both life span and health span are influenced by genetic, environmental and lifestyle factors. With the genetic influence on human life span estimated to be about 20\u201325%, epigenetic changes play an important role in modulating individual health status and aging. Thus, a main part of life expectance and healthy aging is determined by dietary habits and nutritional factors. Excessive or restricted food consumption have direct effects on health status. Moreover, some dietary interventions including a reduced intake of dietary calories without malnutrition, or a restriction of specific dietary component may promote health benefits and decrease the incidence of aging-related comorbidities, thus representing intriguing potential approaches to improve healthy aging. However, the relationship between nutrition, health and aging is still not fully understood as well as the mechanisms by which nutrients and nutritional status may affect health span and longevity in model organisms. The broad effect of different nutritional conditions on health span and longevity occurs through multiple mechanisms that involve evolutionary conserved nutrient-sensing pathways in tissues and organs. These pathways interacting each other include the evolutionary conserved key regulators mammalian target of rapamycin, AMP-activated protein kinase, insulin/insulin-like growth factor 1 pathway and sirtuins. In this review we provide a summary of the main molecular mechanisms by which different nutritional conditions, i.e., specific nutrient abundance or restriction, may affect health span and life span
Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?
Non present
Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of ‘essential’ thiol groups of ornithine decarboxylase
Zinc is required for the expression of ornithine decarboxylase in a difluoromethylornithine-resistant cell line
Teaching Story without Struggle: Using Graded Readers and Their Audio Packs in the EFL Classroom
In recent years the support for extensive reading (ER) in English as a second or foreign language (ESL/EFL) programs has been compelling. When practicing extensive
reading, the learner reads a wide variety of texts for pleasure and achieves a general understanding of the content while deciphering unknown words through context. This approach contrasts with intensive reading, a more
traditional approach based on a slow, careful reading of a text, with goals of complete comprehension and the
identification of specific details and information
Global Compartmental Analysis of the Excited-State Reaction between Fluorescein and (±)- N
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