2,238 research outputs found
Quantum transport through a double Aharonov-Bohm-interferometer in the presence of Andreev reflection
Quantum transport through a double Aharonov-Bohm-interferometer in the
presence of Andreev reflection is investigated in terms of the nonequilibrium
Green function method with which the reflection current is obtained. Tunable
Andreev reflection probabilities depending on the interdot coupling strength
and magnetic flux as well are analysised in detail. It is found that the
oscillation period of the reflection probability with respect to the magnetic
flux for the double interferometer depends linearly on the ratio of two parts
magnetic fluxes n, i.e. 2(n+1)pi, while that of a single interferometer is 2pi.
The coupling strength not only affects the height and the linewidth of Andreev
reflection current peaks vs gate votage but also shifts the peak positions. It
is furthermore demonstrated that the Andreev reflection current peaks can be
tuned by the magnetic fluxes.Comment: 13 pages, 12 figur
Treatment patterns and outcomes in patients with Pancoast tumors: a national cancer database analysis
Background: Pancoast tumors represent 5% of non-small cell lung cancers. Complete surgical resection and no lymph node involvement are important positive prognostic factors. Previous literature has identified neoadjuvant chemoradiation treatment, followed by surgical resection, as the standard of care. But many institutions choose upfront surgery. Our goal was to identify the treatment patterns and outcomes in patients with node-negative Pancoast tumors using the National Cancer Database (NCDB).
Methods: The NCDB was queried from 2004 through 2017 to identify all patients who had undergone surgery for a Pancoast tumor. Treatment patterns, including the percentage of patients who received neoadjuvant treatment, were recorded. Logistic regression and survival analyses were used to determine outcomes based on different treatment patterns. Secondary analyses were performed on the cohort who received upfront surgery.
Results: A total of 2,910 patients were included in the study. Overall 30- and 90-day mortality were 3% and 7% respectively. Only 25% (717/2,910) of the group received neoadjuvant chemoradiation treatment prior to surgery. Patients who received neoadjuvant chemoradiation treatment experienced significantly improved 90-day survival (P\u3c0.01) and overall survival (P\u3c0.01). When analyzing the cohort who received upfront surgery, there was a statistically significant difference in survival based on adjuvant treatment pattern (P\u3c0.01). Patients in this group who received adjuvant chemoradiation had the best survival, whereas patients who received adjuvant radiation only or no treatment had the worst outcomes.
Conclusions: Patients with Pancoast tumors receive neoadjuvant chemoradiation treatment in only a quarter of cases nationally. Patients who received neoadjuvant chemoradiation treatment had improved survival compared to patients who had upfront surgery. Similarly, when surgery is performed first, adjuvant chemoradiation treatment improved survival compared to other adjuvant strategies. These results suggest underutilization of neoadjuvant treatment for patients with node-negative Pancoast tumors. Future studies with a more clearly defined cohort are needed to assess the treatment patterns being utilized on patients with node-negative Pancoast tumors. It will be beneficial to see whether neoadjuvant treatment for Pancoast tumors has increased in recent years
Crystal structure of the N‐terminal region of human Ash2L shows a winged‐helix motif involved in DNA binding
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/1/embr2011101-sup-0001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/2/embr2011101.reviewer_comments.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/3/embr2011101.pd
Scaling of Anisotropic Flows and Nuclear Equation of State in Intermediate Energy Heavy Ion Collisions
Elliptic flow () and hexadecupole flow () of light clusters have
been studied in details for 25 MeV/nucleon Kr + Sn at large
impact parameters by Quantum Molecular Dynamics model with different potential
parameters. Four parameter sets which include soft or hard equation of state
(EOS) with/without symmetry energy term are used. Both number-of-nucleon ()
scaling of the elliptic flow versus transverse momentum () and the scaling
of versus have been demonstrated for the light clusters
in all above calculation conditions. It was also found that the ratio of
keeps a constant of 1/2 which is independent of for all the
light fragments. By comparisons among different combinations of EOS and
symmetry potential term, the results show that the above scaling behaviors are
solid which do not depend the details of potential, while the strength of flows
is sensitive to EOS and symmetry potential term.Comment: 5 pages, 5 figure
Total Reaction Cross Section in an Isospin-Dependent Quantum Molecular Dynamics (IDQMD) Model
The isospin-dependent quantum molecular dynamics (IDQMD) model is used to
study the total reaction cross section . The energy-dependent Pauli
volumes of neutrons and protons have been discussed and introduced into the
IDQMD calculation to replace the widely used energy-independent Pauli volumes.
The modified IDQMD calculation can reproduce the experimental well
for both stable and exotic nuclei induced reactions. Comparisons of the
calculated induced by with different initial density
distributions have been performed. It is shown that the calculation by using
the experimentally deduced density distribution with a long tail can fit the
experimental excitation function better than that by using the
Skyrme-Hartree-Fock calculated density without long tails. It is also found
that at high energy is sensitive to the long tail of density
distribution.Comment: 4 page, 4 fig
Strong and Electromagnetic Decays of X(1835) as a Baryonium State
With the assumption that the recently observed X(1835) is a baryonium state
we have studied the strong decays of and the electromagnetic decay of in the framework of effective Lagrangian formalism. In the present
investigation we have included the contributions from the iso-singlet light
scalar resonances but we have not included the isospin violating effect. Our
result for the strong decay of is
smaller than the observed data. The decay width for the radiative decay of
is consistent with the assumption that it decays through
the glueball. In addition, the width for the strong decay of is larger than that of the strong decay of due to the large phase space and coupling constant
. From our investigation, it is not possible to interpret
X(1835) as a baryonium.Comment: Corrected typo
Fish-T1K (Transcriptomes of 1,000 Fishes) Project: Large-Scale Transcriptome Data for Fish Evolution Studies
Ray-finned fishes (Actinopterygii) represent more than 50 % of extant vertebrates and are of great evolutionary, ecologic and economic significance, but they are relatively underrepresented in ‘omics studies. Increased availability of transcriptome data for these species will allow researchers to better understand changes in gene expression, and to carry out functional analyses. An international project known as the “Transcriptomes of 1,000 Fishes” (Fish-T1K) project has been established to generate RNA-seq transcriptome sequences for 1,000 diverse species of ray-finned fishes. The first phase of this project has produced transcriptomes from more than 180 ray-finned fishes, representing 142 species and covering 51 orders and 109 families. Here we provide an overview of the goals of this project and the work done so far
Noise smoothing for VR equipment in quaternions
Smooth motion generation is an important issue in the computer animation and virtual reality (VR) area. In general, the motion of a rigid body consists of translation and orientation. The former is described by a space curve in 3-dimensional Euclidean space, while the latter is represented by a curve in the unit quaternion space. Although there are well-known techniques for smoothing the translation curve in the Euclidean space, few results have been reported for smoothing motion as a whole. This paper improves the previous study and provides a more robust algorithm, which seeks to minimize the weighted sum of the strain-energy and the sum of the squared errors.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45883/1/10756_2004_Article_206666.pd
Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia
Human bocavirus 1 (HBoV1) has been identified as one of the etiological agents of wheezing in young children with acute respiratory-tract infections. In this study, we have obtained the sequence of a full-length HBoV1 genome (including both termini) using viral DNA extracted from a nasopharyngeal aspirate of an infected patient, cloned the full-length HBoV1 genome, and demonstrated DNA replication, encapsidation of the ssDNA genome, and release of the HBoV1 virions from human embryonic kidney 293 cells. The HBoV1 virions generated from this cell line-based production system exhibits a typical icosahedral structure of approximately 26 nm in diameter, and is capable of productively infecting polarized primary human airway epithelia (HAE) from the apical surface. Infected HAE showed hallmarks of lung airway-tract injury, including disruption of the tight junction barrier, loss of cilia and epithelial cell hypertrophy. Notably, polarized HAE cultured from an immortalized airway epithelial cell line, CuFi-8 (originally derived from a cystic fibrosis patient), also supported productive infection of HBoV1. Thus, we have established a reverse genetics system and generated the first cell line-based culture system for the study of HBoV1 infection, which will significantly advance the study of HBoV1 replication and pathogenesis.This work was supported by PHS R21 grant AI085236 and PHS R01 grant AI070723 from NIAID (J Qiu) and PHS R01 grant HL108902 from NHLBI (J Engelhardt)
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