913 research outputs found
The role of B cells in primary progressive multiple sclerosis
The success of ocrelizumab in reducing confirmed disability accumulation in primary progressive multiple sclerosis (PPMS) via CD20-targeted depletion implicates B cells as causal agents in the pathogenesis of PPMS. This review explores the possible mechanisms by which B cells contribute to disease progression in PPMS, specifically exploring cytokine production, antigen presentation, and antibody synthesis. B cells may contribute to disease progression in PPMS through cytokine production, specifically GM-CSF and IL-6, which can drive naïve T-cell differentiation into pro-inflammatory Th1/Th17 cells. B cell production of the cytokine LT-α may induce follicular dendritic cell production of CXCL13 and lead indirectly to T and B cell infiltration into the CNS. In contrast, production of IL-10 by B cells likely induces an anti-inflammatory effect that may play a role in reducing neuroinflammation in PPMS. Therefore, reduced production of IL-10 may contribute to disease worsening. B cells are also capable of potent antigen presentation and may induce pro-inflammatory T-cell differentiation via cognate interactions. B cells may also contribute to disease activity via antibody synthesis, although it\u27s unlikely the benefit of ocrelizumab in PPMS occurs via antibody decrement. Finally, various B cell subsets likely promulgate pro- or anti-inflammatory effects in MS
Adsorption hysteresis and capillary condensation in disordered porous solids: a density functional study
We present a theoretical study of capillary condensation of fluids adsorbed
in mesoporous disordered media. Combining mean-field density functional theory
with a coarse-grained description in terms of a lattice-gas model allows us to
investigate both the out-of-equilibrium (hysteresis) and the equilibrium
behavior. We show that the main features of capillary condensation in
disordered solids result from the appearance of a complex free-energy landscape
with a large number of metastable states. We detail the numerical procedures
for finding these states, and the presence or absence of transitions in the
thermodynamic limit is determined by careful finite-size studies.Comment: 30 pages, 18 figures. To appear in J. Phys.: Condens. Matte
Light Curves of the Neutron Star Merger GW170817/SSS17a: Implications for R-Process Nucleosynthesis
On 2017 August 17, gravitational waves were detected from a binary neutron
star merger, GW170817, along with a coincident short gamma-ray burst,
GRB170817A. An optical transient source, Swope Supernova Survey 17a (SSS17a),
was subsequently identified as the counterpart of this event. We present
ultraviolet, optical and infrared light curves of SSS17a extending from 10.9
hours to 18 days post-merger. We constrain the radioactively-powered transient
resulting from the ejection of neutron-rich material. The fast rise of the
light curves, subsequent decay, and rapid color evolution are consistent with
multiple ejecta components of differing lanthanide abundance. The late-time
light curve indicates that SSS17a produced at least ~0.05 solar masses of heavy
elements, demonstrating that neutron star mergers play a role in r-process
nucleosynthesis in the Universe.Comment: Accepted to Scienc
Solar Contamination in Extreme-precision Radial-velocity Measurements: Deleterious Effects and Prospects for Mitigation
Solar contamination, due to moonlight and atmospheric scattering of sunlight, can cause systematic errors in stellar radial velocity (RV) measurements that significantly detract from the ~10 cm sâ1 sensitivity required for the detection and characterization of terrestrial exoplanets in or near habitable zones of Sun-like stars. The addition of low-level spectral contamination at variable effective velocity offsets introduces systematic noise when measuring velocities using classical mask-based or template-based cross-correlation techniques. Here we present simulations estimating the range of RV measurement error induced by uncorrected scattered sunlight contamination. We explore potential correction techniques, using both simultaneous spectrometer sky fibers and broadband imaging via coherent fiber imaging bundles, that could reliably reduce this source of error to below the photon-noise limit of typical stellar observations. We discuss the limitations of these simulations, the underlying assumptions, and mitigation mechanisms. We also present and discuss the components designed and built into the NEID (NN-EXPLORE Exoplanet Investigations with Doppler spectroscopy) precision RV instrument for the WIYN 3.5 m telescope, to serve as an ongoing resource for the community to explore and evaluate correction techniques. We emphasize that while "bright time" has been traditionally adequate for RV science, the goal of 10 cm sâ1 precision on the most interesting exoplanetary systems may necessitate access to darker skies for these next-generation instruments
A Radial Velocity Survey of the Cygnus OB2 Association
We conducted a radial velocity survey of the Cygnus OB2 Association over a 6
year (1999 - 2005) time interval to search for massive close binaries. During
this time we obtained 1139 spectra on 146 OB stars to measure mean systemic
radial velocities and radial velocity variations. We spectroscopically identify
73 new OB stars for the first time, the majority of which are likely to be
Association members. Spectroscopic evidence is also presented for a B3Iae
classification and temperature class variation (B3 - B8) on the order of 1 year
for Cygnus OB2 No. 12. Calculations of the intial mass function with the
current spectroscopic sample yield Gamma = -2.2 +/- 0.1. Of the 120 stars with
the most reliable data, 36 are probable and 9 are possible single-lined
spectroscopic binaries. We also identify 3 new and 8 candidate double-lined
spectroscopic binaries. These data imply a lower limit on the massive binary
fraction of 30% - 42%. The calculated velocity dispersion for Cygnus OB2 is
2.44 +/- km/s, which is typical of open clusters. No runaway OB stars were
found.Comment: 56 pages, 23 figures, 5 tables, accepted for publication in the
Astrophysical Journa
Persistent starspot signals on M dwarfs: multi-wavelength Doppler observations with the Habitable-zone Planet Finder and Keck/HIRES
Young, rapidly-rotating M dwarfs exhibit prominent starspots, which create
quasiperiodic signals in their photometric and Doppler spectroscopic
measurements. The periodic Doppler signals can mimic radial velocity (RV)
changes expected from orbiting exoplanets. Exoplanets can be distinguished from
activity-induced false positives by the chromaticity and long-term incoherence
of starspot signals, but these qualities are poorly constrained for
fully-convective M stars. Coherent photometric starspot signals on M dwarfs may
persist for hundreds of rotations, and the wavelength dependence of starspot RV
signals may not be consistent between stars due to differences in their
magnetic fields and active regions. We obtained precise multi-wavelength RVs of
four rapidly-rotating M dwarfs (AD Leo, G 227-22, GJ 1245B, GJ 3959) using the
near-infrared (NIR) Habitable-zone Planet Finder, and the optical Keck/HIRES
spectrometer. Our RVs are complemented by photometry from Kepler, TESS, and the
Las Cumbres Observatory (LCO) network of telescopes. We found that all four
stars exhibit large spot-induced Doppler signals at their rotation periods, and
investigated the longevity and optical-to-NIR chromaticity for these signals.
The phase curves remain coherent much longer than is typical for Sunlike stars.
Their chromaticity varies, and one star (GJ 3959) exhibits optical and NIR RV
modulation consistent in both phase and amplitude. In general, though, we find
that the NIR amplitudes are lower than their optical counterparts. We conclude
that starspot modulation for rapidly-rotating M stars frequently remains
coherent for hundreds of stellar rotations, and gives rise to Doppler signals
that, due to this coherence, may be mistaken for exoplanets.Comment: Accepted for publication in the Astrophysical Journa
Evidence of strong stabilizing effects on the evolution of boreoeutherian (Mammalia) dental proportions.
The dentition is an extremely important organ in mammals with variation in timing and sequence of eruption, crown morphology, and tooth size enabling a range of behavioral, dietary, and functional adaptations across the class. Within this suite of variable mammalian dental phenotypes, relative sizes of teeth reflect variation in the underlying genetic and developmental mechanisms. Two ratios of postcanine tooth lengths capture the relative size of premolars to molars (premolar-molar module, PMM), and among the three molars (molar module component, MMC), and are known to be heritable, independent of body size, and to vary significantly across primates. Here, we explore how these dental traits vary across mammals more broadly, focusing on terrestrial taxa in the clade of Boreoeutheria (Euarchontoglires and Laurasiatheria). We measured the postcanine teeth of NÂ =Â 1,523 boreoeutherian mammals spanning six orders, 14 families, 36 genera, and 49 species to test hypotheses about associations between dental proportions and phylogenetic relatedness, diet, and life history in mammals. Boreoeutherian postcanine dental proportions sampled in this study carry conserved phylogenetic signal and are not associated with variation in diet. The incorporation of paleontological data provides further evidence that dental proportions may be slower to change than is dietary specialization. These results have implications for our understanding of dental variation and dietary adaptation in mammals
Nuclear transparency and effective kaon-nucleon cross section from the A(e, e'K+) reaction
We have determined the transparency of the nuclear medium to kaons from
measurements on C, Cu, and Au targets.
The measurements were performed at the Jefferson Laboratory and span a range in
four-momentum-transfer squared Q=1.1 -- 3.0 GeV. The nuclear
transparency was defined as the ratio of measured kaon electroproduction cross
sections with respect to deuterium, (). We further
extracted the atomic number () dependence of the transparency as
parametrized by and, within a simple model assumption,
the in-medium effective kaon-nucleon cross sections. The effective cross
sections extracted from the electroproduction data are found to be smaller than
the free cross sections determined from kaon-nucleon scattering experiments,
and the parameter was found to be significantly larger than those
obtained from kaon-nucleus scattering. We have included similar comparisons
between pion- and proton-nucleon effective cross sections as determined from
electron scattering experiments, and pion-nucleus and proton-nucleus scattering
data.Comment: 7 pages, 5 figure
TOI-150: A transiting hot Jupiter in the TESS southern CVZ
We report the detection of a hot Jupiter ($M_{p}=1.75_{-0.17}^{+0.14}\
M_{J}R_{p}=1.38\pm0.04\ R_{J}\log
g=4.152^{+0.030}_{-0.043}\beta=-79.59^{\circ}$). We confirm the
planetary nature of the candidate TOI-150.01 using radial velocity observations
from the APOGEE-2 South spectrograph and the Carnegie Planet Finder
Spectrograph, ground-based photometric observations from the robotic
Three-hundred MilliMeter Telescope at Las Campanas Observatory, and Gaia
distance estimates. Large-scale spectroscopic surveys, such as APOGEE/APOGEE-2,
now have sufficient radial velocity precision to directly confirm the signature
of giant exoplanets, making such data sets valuable tools in the TESS era.
Continual monitoring of TOI-150 by TESS can reveal additional planets and
subsequent observations can provide insights into planetary system
architectures involving a hot Jupiter around a star about halfway through its
main-sequence life.Comment: 13 pages, 3 figures, 2 tables, accepted to ApJ
The Frequency of Mid-Infrared Excess Sources in Galactic Surveys
We have identified 230 Tycho-2 Spectral Catalog stars that exhibit 8 micron
mid-infrared extraphotospheric excesses in the MidCourse Space Experiment (MSX)
and Spitzer Space Telescope Galactic Legacy MidPlane Survey Extraordinaire
(GLIMPSE) surveys. Of these, 183 are either OB stars earlier than B8 in which
the excess plausibly arises from a thermal bremsstrahlung component or evolved
stars in which the excess may be explained by an atmospheric dust component.
The remaining 47 stars have spectral classifications B8 or later and appear to
be main sequence or late pre-main-sequence objects harboring circumstellar
disks. Six of the 47 stars exhibit multiple signatures characteristic of
pre-main-sequence circumstellar disks, including emission lines, near-infrared
K-band excesses, and X-ray emission. Approximately one-third of the remaining
41 sources have emission lines suggesting relative youth. Of the 25 GLIMPSE
stars with SST data at >24 microns, 20 also show an excess at 24 microns. Three
additional objects have 24 micron upper limits consistent with possible
excesses, and two objects have photospheric measurements at 24 microns. Six MSX
sources had a measurement at wavelengths >8 microns. We modeled the excesses in
26 stars having two or more measurements in excess of the expected photospheres
as single-component blackbodies. We determine probable disk temperatures and
fractional infrared luminosities in the range 191 < T < 787 and 3.9x10^-4 <
L_IR/L_* < 2.7x10^-1. We estimate a lower limit on the fraction of Tycho-2
Spectral Catalog main-sequence stars having mid-IR, but not near-IR, excesses
to be 1.0+-0.3%.Comment: Accepted to Ap
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