Perspective:Dietary Biomarkers of Intake and Exposure - Exploration with Omics Approaches

While conventional nutrition research has yielded biomarkers such as doubly labeled water for energy metabolism and 24-h urinary nitrogen for protein intake, a critical need exists for additional, equally robust biomarkers that allow for objective assessment of specific food intake and dietary exposure. Recent advances in high-throughput MS combined with improved metabolomics techniques and bioinformatic tools provide new opportunities for dietary biomarker development. In September 2018, the NIH organized a 2-d workshop to engage nutrition and omics researchers and explore the potential of multiomics approaches in nutritional biomarker research. The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research. Topics addressed included study designs for biomarker development, analytical and bioinformatic considerations, and integration of dietary biomarkers with other omics techniques. Several clear needs were identified, including larger controlled feeding studies, testing a variety of foods and dietary patterns across diverse populations, improved reporting standards to support study replication, more chemical standards covering a broader range of food constituents and human metabolites, standardized approaches for biomarker validation, comprehensive and accessible food composition databases, a common ontology for dietary biomarker literature, and methodologic work on statistical procedures for intake biomarker discovery. Multidisciplinary research teams with appropriate expertise are critical to moving forward the field of dietary biomarkers and producing robust, reproducible biomarkers that can be used in public health and clinical research

Trace elements in hemodialysis patients: a systematic review and meta-analysis

<p>Abstract</p> <p>Background</p> <p>Hemodialysis patients are at risk for deficiency of essential trace elements and excess of toxic trace elements, both of which can affect health. We conducted a systematic review to summarize existing literature on trace element status in hemodialysis patients.</p> <p>Methods</p> <p>All studies which reported relevant data for chronic hemodialysis patients and a healthy control population were eligible, regardless of language or publication status. We included studies which measured at least one of the following elements in whole blood, serum, or plasma: antimony, arsenic, boron, cadmium, chromium, cobalt, copper, fluorine, iodine, lead, manganese, mercury, molybdenum, nickel, selenium, tellurium, thallium, vanadium, and zinc. We calculated differences between hemodialysis patients and controls using the differences in mean trace element level, divided by the pooled standard deviation.</p> <p>Results</p> <p>We identified 128 eligible studies. Available data suggested that levels of cadmium, chromium, copper, lead, and vanadium were higher and that levels of selenium, zinc and manganese were lower in hemodialysis patients, compared with controls. Pooled standard mean differences exceeded 0.8 standard deviation units (a large difference) higher than controls for cadmium, chromium, vanadium, and lower than controls for selenium, zinc, and manganese. No studies reported data on antimony, iodine, tellurium, and thallium concentrations.</p> <p>Conclusion</p> <p>Average blood levels of biologically important trace elements were substantially different in hemodialysis patients, compared with healthy controls. Since both deficiency and excess of trace elements are potentially harmful yet amenable to therapy, the hypothesis that trace element status influences the risk of adverse clinical outcomes is worthy of investigation.</p

Discrete Correlation Summation Clustering Reveals Differential Regulation of Liver Metabolism by Thrombospondin-1 in Low-Fat and High-Fat Diet-Fed Mice

Thrombospondin-1 (TSP1) is a matricellular protein with many important roles in mediating carcinogenesis, fibrosis, leukocyte recruitment, and metabolism. We have previously shown a role of diet in the absence of TSP1 in liver metabolism in the context of a colorectal cancer model. However, the metabolic implications of TSP1 regulation by diet in the liver metabolism are currently understudied. Therefore Discrete correlation summation (DCS) was used to re-interrogate data and determine the metabolic alterations of TSP1 deficiency in the liver, providing new insights into the role of TSP1 in liver injury and the progression of liver pathologies such as nonalcoholic fatty liver disease (NAFLD). DCS analysis provides a straightforward approach to rank covariance and data clustering when analyzing complex data sets. Using this approach, our previous liver metabolite data was re-analyzed by comparing wild-type (WT) and Thrombospondin-1 null (Thbs1&minus;/&minus;) mice, identifying changes driven by genotype and diet. Principal component analysis showed clustering of animals by genotype regardless of diet, indicating that TSP1 deficiency alters metabolite handling in the liver. High-fat diet consumption significantly altered over 150 metabolites in the Thbs1&minus;/&minus; livers versus approximately 90 in the wild-type livers, most involved in amino acid metabolism. The absence of Thbs1 differentially regulated tryptophan and tricarboxylic acid cycle metabolites implicated in the progression of NAFLD. Overall, the lack of Thbs1 caused a significant shift in liver metabolism with potential implications for liver injury and the progression of NAFLD

Additional Space : Hibbelton Gallery

This compilation of works, created by various art students from BIOLA University, investigates the influence of spatial awareness, both tangible and intangible. These varying approaches to define Additional Space are expressed through diverse media, displaying the inability to set physical limitations on the concept. CURATORIAL TEAM: Leslie Chung, Jessica Guerra, Haley Hood Erin Jeffries, Melanie Kim, Alexis Rojas, Jinghua Ye Images of artwork by Nathaniel Colbert, Kearci Moir, Melody Phillips & Chris Rasmussen provided by the artist; used by permission. All other artwork and installation images by Jeff Rau and Melanie Kim from Additional Space exhibition at Hibbleton Gallery, Fullerton, CA. Cover design by Leslie Chung, Jessica Guerra, and Erin Jeffries featuring detail of artwork by Rachel Emenaker.Images of artwork by Nathaniel Colbert, Kearci Moir, Melody Phillips & Chris Rasmussen provided by the artist; used by permission. All other artwork and installation images by Jeff Rau and Melanie Kim from Additional Space exhibition at Hibbleton Gallery, Fullerton, CA. Cover design by Leslie Chung, Jessica Guerra, and Erin Jeffries featuring detail of artwork by Rachel Emenaker. Book design by Leslie Chung and Jessica Guerra. Self Portrait - sculpture - ANGELICA NICOLLE ABALOS; Untitled - painting, mixed media - ALEXIS AQUILINA; His/Hers - painting, mixed media - ALEXIS AQUILINA; Untitled #1 - ceramics - HANNAH BROWN; Over the Face of the Deep - video - TYLER CASH, TYLER DAVIS, NICO HERNANDEZ & CHRIS RASMUSSEN; Portrait of Grace, Matthew, and Heidi - photograpphy - LESLIE CHUNG; Sistine Chapel Sketches, Skyline, and Bubbles - ADRIANNA COE; Woman Series - painting - ADRIANNA COE; Connect 1 - photography - NATHANIEL COLBERT; Vanishing (Exist) - RACHEL EMENAKER; Red Triangles - painting - LAUREN HIGGINS; Glint - printmaking - SOREN IVERSON; Untitled - photography - MELANIE KIM; Untitled #1, Untitled #2 - photography - DANIEL LAMBERT; #1, #3 - photography - ZECHARIAH LISZEWSKI; Uninterrupted - painting, drawing - RANDI MARTINEZ; Avoid The Confusion - photography - KEARCI MOIR; Pool Toys for Pool Boys - painting - LITT ODOM; Time and Space - drawing - MELODY PHILLIPS; Church of the Open Door - photography - CHRIS RASMUSSEN; Polarity #1, Polarity #2 - photography - CHRIS RASMUSSEN; Bark - LISL RUCKERT; Seize - painting - AMANDA UPP; Transgression - sculpture - JINGHUA YE;https://digitalcommons.biola.edu/exhibit-catalogs/1016/thumbnail.jp

Voice in the void

This exhibition features artworks that confront and explore the relationship between the void space and us: the artist, the viewer, the human. A void is more than just an empty space, it can be a formal component of an artwork such as: the negative space in a sculpture, an expanse of color across a canvas, or the embodiment of a feeling. A void can also be a problem or an unknown we must all confront. It can be painful or it can be wonderful... These 24 student artists boldly confront and search the relationship between listening and answering. This show explores this aspect of the human experience and how we express ourselves in the midst of physical or emotional absence. Our goal is for these voices to reach beyond the void. Curatorial team: Brooke Braden, Adrianna Coe, Jessica Dueker, Savannah Morra, Elaina Swanson Old Soul, New Life - drawing - Adrianna Coe; Formless and Void - painting - Devan Carpentier; All Dolled Up - Jessica Byrd; 5’ 11” - film - Kathryn Ashford; Untitled ( 10) - photography - MIchael Hallman; Untitled (response to California Life) - ceramic - Hannah Brown; Untitled (#1) - Sarah Sundberg; Untitled 10.1-2 - drawing - Sarah Starck; March - drawing - Cherish Travnick; Untitled - photography - Daniel Lambert; Fertilizing the Lawn With Calcium # 1 and Fertilizing the Lawn With Calcium # 4 - mixed media - Hope Daley; Love Your Home - photography - Ludo Krabbendam; You Could Sense That I Was There - photography - Nico Hernandez; Parallel - photography - Melanie Kim; A Captured World ( Wild) - painting - Rachel Emanaker; Untitled (#1) - photography - Michael Hallman; Platform - photography - Kira Bester; Untitled - sculpture - Alexis Aquilina; False Memories - drawing - Alex Sarina; 150. But Who’s Counting? - mixed media - Jessica Byrd; Words of Condemnation - photography - Ryan Cook; Anxiety - photography - Shelby Montelongo; Just Hold On - drawing, mixed media - Jessica Byrd; The First Release - mixed media - Savannah Morra; It Was Like a Fire - painting, mixed media - Alexis Aquilina; The Blessing - sculpture - Hannah Brown; Psalm 8 - audio - Michelle Lum; What Are You Running From? and Haunted - photography - Chris Rasmussen; 48.75° N, 122.47° W (1-3) - photography - Chris Rasmussen; Lighted Shadow - photography - Kira Bester; On The Road - photography - Kira Bester; Possession - mixed media - Alex Sarina; Silence (Organized) - mixed media - Rachel Emenaker; The gesture, not the substance of a prayer” - painting - Alexis Aquilina; Conversation and Breathe - photography - Cody Kim;https://digitalcommons.biola.edu/exhibit-catalogs/1017/thumbnail.jp

Perspective: Dietary Biomarkers of Intake and Exposure—Exploration with Omics Approaches

While conventional nutrition research has yielded biomarkers such as doubly labeled water for energy metabolism and 24-h urinary nitrogen for protein intake, a critical need exists for additional, equally robust biomarkers that allow for objective assessment of specific food intake and dietary exposure. Recent advances in high-throughput MS combined with improved metabolomics techniques and bioinformatic tools provide new opportunities for dietary biomarker development. In September 2018, the NIH organized a 2-d workshop to engage nutrition and omics researchers and explore the potential of multiomics approaches in nutritional biomarker research. The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research. Topics addressed included study designs for biomarker development, analytical and bioinformatic considerations, and integration of dietary biomarkers with other omics techniques. Several clear needs were identified, including larger controlled feeding studies, testing a variety of foods and dietary patterns across diverse populations, improved reporting standards to support study replication, more chemical standards covering a broader range of food constituents and human metabolites, standardized approaches for biomarker validation, comprehensive and accessible food composition databases, a common ontology for dietary biomarker literature, and methodologic work on statistical procedures for intake biomarker discovery. Multidisciplinary research teams with appropriate expertise are critical to moving forward the field of dietary biomarkers and producing robust, reproducible biomarkers that can be used in public health and clinical research

BFA 2015-2016 Senior Show Catalog

Carnation Pink - design - Kat Ashford What If - design - Noah Schrader Weekend Warrior - design - Olivia Kincaid Variant - design - Brianna Babcock Rockhounder - design - James McCahon Jemika (Jessica, Michelle, Katherine) - design - Jessica Guerra Driving Fast Car - photography - Chris Rasmussen The House that I Grew Up In, Of Which I Often Dream - design - Lex Aquilina Rational But Not Animal - design - Ryan Cook Uncharted Territory - design - Jessica Byrd Earthly Soles - design - Robyn Barta Eulogy - drawing - Arlene Cortes Mahalo Come Again - design - Haylee Soma Way of the Mind - drawing - Jacob Lucca Foreign Exchange - design - Grace Pan Unidentified Species - drawing - Gabriel Voris Following Cairn - design - Sydney Hallman Bear with One Another - sculpture - Ellen Cambruzzi Jayden - photography - Stella Sim Until Trees Sing - painting - Hannah Brown Fruition - design - Leslie Chung Death or Rest - interdisciplinary - Sarah Sundberg Lethe - painting - Rachel Emenaker Hammer and Nail - design - John Griffith Heirlooms - Jenn Jenison Is This remembrance... - photography - Natalie Crane Bad Luck For A Long Time - sculpture - Allison Winters Excuse Me - photography - Rachel Malek Bleach Dry - design - Tyler Cash In You - drawing/painting - Choongman Lee Confession - design - Hannah Hughes Nonmonotonous - sculpture - Rachel Crichton Dark - design - Sarah Starck Book design concept by Melanie Kim.Book layout by Melanie Kim and Chad Swanson.https://digitalcommons.biola.edu/exhibit-catalogs/1005/thumbnail.jp