The role of platelet microvesicles in intercellular communication.

In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as important mediators of intercellular communication. There are examples of PMV exerting physiological effects on almost all hematological and vascular cell types, including monocytes, macrophages, neutrophils, T-cells, endothelium cells, and smooth muscle cells (SMCs). PMV can exert these effects by multiple methods: extracellular signaling through receptors, transfer of surface molecules, and delivery of intracellular contents including miRNA. Recent work suggests a complex environment in which cellular contents are being shared multi-directionally between multiple cell types. This review will focus on the communicative properties of PMV

Tunnelling between non-centrosymmetric superconductors with significant spin-orbit splitting studied theoretically within a two-band treatment

Tunnelling between non-centrosymmetric superconductors with significant spin-orbit splitting is studied theoretically in a two-band treatment of the problem. We find that the critical Josephson current may be modulated by changing the relative angle between the vectors describing absence of inversion symmetry on each side of the junction. The presence of two gaps also results in multiple steps in the quasiparticle current-voltage characteristics. We argue that both these effects may help to determine the pairing states in materials like CePt$_3$Si, UIr and Cd$_2$Re$_2$O$_7$. We propose experimental tests of these ideas, including scanning tunnelling microscopy.Comment: 5 pages, 1 figure. Minor changes. Some new references added. Journal-ref. adde

A topological bound for electroweak vortices from supersymmetry

We study the connection between N=2 supersymmetry and a topological bound in a two-Higgs doublet system having an SU(2)\times U(1)_Y\times U(1)_{Y^{\prime}} gauge group. We derive Bogomol'nyi equations from supersymmetry considerations showing that they hold provided certain conditions on the coupling constants, which are a consequence of the huge symmetry of the theory, are satisfied. Certain interesting limiting cases of our model are analysed

Spontaneous kidney rupture in polyarteritis nodosa presenting as an acute abdomen

CITATION: Edelstein, C. L. & Welke, H. 1991. Spontaneous kidney rupture in polyarteritis nodosa presenting as an acute abdome. South African Medical Journal, 79:52-53.The original publication is available at http://www.samj.org.zaAn acute abdomen in a patient with polyarteritis nodosa (PAN) is a perplexing and challenging problem for both the physician and the surgeon.Publisher’s versio

Real Estate Income and Value Cycles: A Model of Market Dynamics

We develop a theoretical real estate cycles model linking economic fundamentals to real estate income and value. We estimate and test an econometric model specification, based on the theoretical model, using MSA level data for twenty office markets in the United States. Our major conclusion is that cities that exhibit seemingly different cyclical office market behavior may be statistically characterized by our three-parameter econometric specification. The parameters are MSA-specific amplitude, through the CAP rate, cycle duration (peak-to-peak), via the rate of partial adjustments to changing expectations about stabilized NOI and the market trend.

Spontaneous kidney rupture in polyarteritis nodosa presenting as an acute abdomen

CITATION: Edelstein, C. L. & Welke, H. 1991. Spontaneous kidney rupture in polyarteritis nodosa presenting as an acute abdome. South African Medical Journal, 79:52-53.The original publication is available at http://www.samj.org.zaAn acute abdomen in a patient with polyarteritis nodosa (PAN) is a perplexing and challenging problem for both the physician and the surgeon.Publisher’s versio

NMR relaxation rate in non-centrosymmetric superconductors

The spin-lattice relaxation rate of nuclear magnetic resonance in a clean superconductor without inversion center is calculated for arbitrary pairing symmetry and band structure, in the presence of strong spin-orbit coupling.Comment: 4 page

Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.

Platelet activation in response to stimulation of the Protease Activated Receptor 4 (PAR4) receptor differs by race. One factor that contributes to this difference is the expression level of Phosphatidylcholine Transfer Protein (PCTP), a regulator of platelet PAR4 function. We have conducted an expression Quantitative Trait Locus (eQTL) analysis that identifies single nucleotide polymorphisms (SNPs) linked to the expression level of platelet genes. This analysis revealed 26 SNPs associated with the expression level of PCTP at genome-wide significance (p \u3c 5×10(-8)). Using annotation from ENCODE and other public data we prioritised one of these SNPs, rs2912553, for functional testing. The allelic frequency of rs2912553 is racially-dimorphic, in concordance with the racially differential expression of PCTP. Reporter gene assays confirmed that the single nucleotide change caused by rs2912553 altered the transcriptional potency of the surrounding genomic locus. Electromobility shift assays, luciferase assays, and overexpression studies indicated a role for the megakaryocytic transcription factor GATA1. In summary, we have integrated multi-omic data to identify and functionalise an eQTL. This, along with the previously described relationship between PCTP and PAR4 function, allows us to characterise a genotype-phenotype relationship through the mechanism of gene expression