5,698 research outputs found
A study of cryogenic propellant mixing techniques. Volume 1 - Mixer design and experimental investigations Final report, Jul. 1967 - Sep. 1968
Mixer design and experimental tank study for cryogenic propellants, with applications for manned Mars missio
Piceatannol, a Dietary Polyphenol, Alleviates Adipose Tissue Loss in Pre-Clinical Model of Cancer-Associated Cachexia via Lipolysis Inhibition
Cancer-associated cachexia (CAC) is the nutrition-independent loss of lean muscle and adipose tissues, and results in reduced chemotherapy effectiveness and increased mortality. Prevent- ing adipose loss is considered a key target in the early stages of cachexia. Lipolysis is considered the central driver of adipose loss in CAC. We recently found that piceatannol, but not its analogue resveratrol, exhibits an inhibitory effect on lipolysis. The objective of this study was to investigate the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. Cancer cell- induced lipolysis in adipocytes was stimulated using cancer-conditioned media (CCM) or co-culture with human pancreatic cancer cells and the cachexia-associated cytokines TNF-α and interleukin-6 in 3T3-L1 adipocytes. C26 colon carcinoma-bearing mice were modeled using CAC in vivo. Piceatannol reduced cancer-associated lipolysis by at least 50% in both CCM and cytokine-induced lipolysis in vitro. Further gene and protein analysis confirmed that piceatannol modulated the stability of lipolytic proteins. Moreover, piceatannol protected tumor-bearing mice against weight-loss in early stages of CAC largely through preserving adipose tissue, with no effect on survival. This study demonstrates the use of a dietary compound to preserve adipose in models of early stage CAC and provides groundwork for further investigation of piceatannol or piceatannol-rich foods as alternative medicine in the preservation of body fat mass and future CAC therapy
Piceatannol, a Dietary Polyphenol, Alleviates Adipose Tissue Loss in Pre-Clinical Model of Cancer-Associated Cachexia via Lipolysis Inhibition
Cancer-associated cachexia (CAC) is the nutrition-independent loss of lean muscle and adipose tissues, and results in reduced chemotherapy effectiveness and increased mortality. Preventing adipose loss is considered a key target in the early stages of cachexia. Lipolysis is considered the central driver of adipose loss in CAC. We recently found that piceatannol, but not its analogue resveratrol, exhibits an inhibitory effect on lipolysis. The objective of this study was to investigate the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. Cancer cellinduced lipolysis in adipocytes was stimulated using cancer-conditioned media (CCM) or co-culture with human pancreatic cancer cells and the cachexia-associated cytokines TNF-α and interleukin-6 in 3T3-L1 adipocytes. C26 colon carcinoma-bearing mice were modeled using CAC in vivo. Piceatannol reduced cancer-associated lipolysis by at least 50% in both CCM and cytokine-induced lipolysis in vitro. Further gene and protein analysis confirmed that piceatannol modulated the stability of lipolytic proteins. Moreover, piceatannol protected tumor-bearing mice against weight-loss in early stages of CAC largely through preserving adipose tissue, with no effect on survival. This study demonstrates the use of a dietary compound to preserve adipose in models of early stage CAC and provides groundwork for further investigation of piceatannol or piceatannol-rich foods as alternative medicine in the preservation of body fat mass and future CAC therap
Identifying spin-triplet pairing in spin-orbit coupled multi-band superconductors
We investigate the combined effect of Hund's and spin-orbit (SO) coupling on
superconductivity in multi-orbital systems. Hund's interaction leads to
orbital-singlet spin-triplet superconductivity, where the Cooper pair wave
function is antisymmetric under the exchange of two orbitals. We identify three
d-vectors describing even-parity orbital-singlet spin-triplet pairings among
t2g-orbitals, and find that the three d-vectors are mutually orthogonal to each
other. SO coupling further assists pair formation, pins the orientation of the
d-vector triad, and induces spin-singlet pairings with a relative phase
difference of \pi/2. In the band basis the pseudospin d-vectors are aligned
along the z-axis and correspond to momentum-dependent inter- and intra-band
pairings. We discuss quasiparticle dispersion, magnetic response, collective
modes, and experimental consequences in light of the superconductor Sr2RuO4.Comment: 6 pages, 5 figure
Camera for QUasars in EArly uNiverse (CQUEAN)
We describe the overall characteristics and the performance of an optical CCD
camera system, Camera for QUasars in EArly uNiverse (CQUEAN), which is being
used at the 2.1 m Otto Struve Telescope of the McDonald Observatory since 2010
August. CQUEAN was developed for follow-up imaging observations of red sources
such as high redshift quasar candidates (z >= 5), Gamma Ray Bursts, brown
dwarfs, and young stellar objects. For efficient observations of the red
objects, CQUEAN has a science camera with a deep depletion CCD chip which
boasts a higher quantum efficiency at 0.7 - 1.1 um than conventional CCD chips.
The camera was developed in a short time scale (~ one year), and has been
working reliably. By employing an auto-guiding system and a focal reducer to
enhance the field of view on the classical Cassegrain focus, we achieve a
stable guiding in 20 minute exposures, an imaging quality with FWHM >= 0.6"
over the whole field (4.8' * 4.8'), and a limiting magnitude of z = 23.4 AB mag
at 5-sigma with one hour total integration time.Comment: Accepted for publication in PASP. 26 pages including 5 tables and 24
figure
Half-quantum vortex and d-soliton in SrRuO
Assuming that the superconductivity in SrRuO is described by a planar
p-wave order parameter, we consider possible topological defects in
SrRuO. In particular, it is shown that both of the -soliton
and half-quantum vortex can be created in the presence of the magnetic field
parallel to the - plane. We discuss how one can detect the -soliton and half-quantum vortex experimentally.Comment: 8 pages, 3 figure
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Aligning Interdisciplinary Healthcare Team Behavior with Workflow Execution: An Example of a Radical Prostatectomy Workflow
Operationalizing care delivery through an interdisciplinary healthcare team (IHT) requires knowledge about the overall structure of an IHT and the behavioral rules that "control" the dynamics of this structure interpreted as team and clinical leadership maintenance and task allocation. While progress has been made in understanding IHT structure, there is less work on the behavioral aspects of an IHT associated with its dynamics. In this paper we fill this void by extending our Team and Workflow Management Framework (TWMF) with a set of rules to operationalize IHT behavior in terms of clinical leadership, coordination of workflow execution over multiple days as part of continuity of care, and management of tasks, including urgent ones that prevent planned workflow execution. We briefly describe a proof-of-concept implementation of extended TWMF in the form of a computer system for supporting cooperative execution of clinical workflows by an IHT. The system is built on top of an existing business workflow execution engine and employs behavioral rules to control the IHT behavior. We also illustrate the operations of TWMF in a case study where an IHT is executing a workflow for the management of post-operative inpatient recovery after radical prostatectomy
Degeneracy analysis for a super cell of a photonic crystal and its application to the creation of band gaps
A method is introduced to analyze the degeneracy properties of the band
structure of a photonic crystal making use of the super cells. The band
structure associated with a super cell of a photonic crystal has degeneracies
at the edge of the Brillouin zone if the photonic crystal has some kind of
point group symmetry. Both E-polarization and H-polarization cases have the
same degeneracies for a 2-dimensional (2D) photonic crystal. Two theorems are
given and proved. These degeneracies can be lifted to create photonic band gaps
by changing the transform matrix between the super cell and the smallest unit
cell. The existence of the photonic band gaps for many known 2D photonic
crystals is explained through the degeneracy analysis.Comment: 19 pages, revtex4, 14 figures, p
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