17,067 research outputs found
Geometric approach to Fletcher's ideal penalty function
Original article can be found at: www.springerlink.com Copyright Springer. [Originally produced as UH Technical Report 280, 1993]In this note, we derive a geometric formulation of an ideal penalty function for equality constrained problems. This differentiable penalty function requires no parameter estimation or adjustment, has numerical conditioning similar to that of the target function from which it is constructed, and also has the desirable property that the strict second-order constrained minima of the target function are precisely those strict second-order unconstrained minima of the penalty function which satisfy the constraints. Such a penalty function can be used to establish termination properties for algorithms which avoid ill-conditioned steps. Numerical values for the penalty function and its derivatives can be calculated efficiently using automatic differentiation techniques.Peer reviewe
Would Two Dimensions be World Enough for Spacetime?
We consider various curious features of general relativity, and relativistic
field theory, in two spacetime dimensions. In particular, we discuss: the
vanishing of the Einstein tensor; the failure of an initial-value formulation
for vacuum spacetimes; the status of singularity theorems; the non-existence of
a Newtonian limit; the status of the cosmological constant; and the character
of matter fields, including perfect fluids and electromagnetic fields. We
conclude with a discussion of what constrains our understanding of physics in
different dimensions.Comment: 31 pages, 1 figur
Interpretation of the angular dependence of the de Haas-van Alphen effect in MgB_2
We present detailed results for the amplitude and field dependence of the de
Haas-van Alphen (dHvA) signal arising from the electron-like sheet of
Fermi surface in MgB_2. Our data and analysis show that the dip in dHvA
amplitude when the field is close to the basal plane is caused by a beat
between two very similar dHvA frequencies and not a spin-zero effect as
previously assumed. Our results imply that the Stoner enhancement factors in
MgB_2 are small on both the Sigma and Pi sheets.Comment: 4 pages with figures. Submitted to PR
Polyimide processing additives
A process for preparing polyimides having enhanced melt flow properties is described. The process consists of heating a mixture of a high molecular weight poly-(amic acid) or polyimide with a low molecular weight amic acid or imide additive in the range of 0.05 to 15 percent by weight of additive. The polyimide powders so obtained show improved processability, as evidenced by lower melt viscosity by capillary rheometry. Likewise, films prepared from mixtures of polymers with additives show improved processability with earlier onset of stretching by TMA
Systemic inflammation predicts all-cause mortality: a Glasgow Inflammation Outcome Study
Introduction:
Markers of the systemic inflammatory response, including C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score), as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in patients with cancer. The aim of the present study was to examine the prognostic relationship between these markers of the systemic inflammatory response and all-cause, cancer, cardiovascular and cerebrovascular mortality in a large incidentally sampled cohort.<p></p>
Methods:
Patients (n = 160 481) who had an incidental blood sample taken between 2000 and 2008 were studied for the prognostic value of C-reactive protein (>10mg/l, albumin (>35mg/l), neutrophil (>7.5×109/l) lymphocyte and platelet counts. Also, patients (n = 52 091) sampled following the introduction of high sensitivity C-reactive protein (>3mg/l) measurements were studied. A combination of these markers, to make cumulative inflammation-based scores, were investigated.<p></p>
Results:
In all patients (n = 160 481) C-reactive protein (>10mg/l) (HR 2.71, p<0.001), albumin (>35mg/l) (HR 3.68, p<0.001) and neutrophil counts (HR 2.18, p<0.001) were independently predictive of all-cause mortality. These associations were also observed in cancer, cardiovascular and cerebrovascular mortality before and after the introduction of high sensitivity C-reactive protein measurements (>3mg/l) (n = 52 091). A combination of high sensitivity C-reactive protein (>3mg/l), albumin and neutrophil count predicted all-cause (HR 7.37, p<0.001, AUC 0.723), cancer (HR 9.32, p<0.001, AUC 0.731), cardiovascular (HR 4.03, p<0.001, AUC 0.650) and cerebrovascular (HR 3.10, p<0.001, AUC 0.623) mortality.
Conclusion
The results of the present study showed that an inflammation-based prognostic score, combining high sensitivity C-reactive protein, albumin and neutrophil count is prognostic of all-cause mortality
21st-Century Skillset Perceptions of Students in an Information Technology Career Academy Compared to those at a Comprehensive School
In this study, we compared the perspectives of students’ 21st-Century competencies (critical thinking and communication, applied learning, and intrapersonal and interpersonal skills) based on participating in an urban magnet information technology (IT) career academy compared to a traditional, comprehensive high school. We utilized propensity score matching to match academy and comprehensive high school learners on various demographic variables. The propensity score matching resulted in 299 matched pairs (n = 598). Using the matched groups, we ran linear regression models to investigate the relationship between school participation and students’ perceptions of their 21st-Century skill attainment. We found that when compared with their comprehensive school peers, academy students believed their schools significantly contributed more to their abilities to apply knowledge from their coursework to a real-world context. We found no significant differences in critical thinking and communication skills as well as intrapersonal and interpersonal skills. Our findings indicate that the nature of the curriculum and instructional strategies within a career academy are beneficial. These strategies include the use of curriculum integration, work-based learning, and project-based learning to increase the meaningfulness and relevancy of content
Classical noise and flux: the limits of multi-state atom lasers
By direct comparison between experiment and theory, we show how the classical
noise on a multi-state atom laser beam increases with increasing flux. The
trade off between classical noise and flux is an important consideration in
precision interferometric measurement. We use periodic 10 microsecond
radio-frequency pulses to couple atoms out of an F=2 87Rb Bose-Einstein
condensate. The resulting atom laser beam has suprising structure which is
explained using three dimensional simulations of the five state
Gross-Pitaevskii equations.Comment: 4 pages, 3 figure
A simplified protocol for detecting two systemic bait markers (Rhodamine B and iophenoxic acid) in small mammals
We developed a method of quantifying levels of fluorescence in the whiskers of wild stoats (Mustela erminea) using fluorescence microscopy and Axiovision 3.0.6.1 software. The method allows for discrimination between natural fluorescence present in or on a whisker, and the fluorescence resulting from the ingestion of the systemic marker Rhodamine B (RB), although some visual judgement is still required. We also developed a new high performance liquid chromatography (HPLC) protocol for detecting the systemic marker iophenoxic acid (IPA) in the blood of laboratory rats (Rattus norvegicus) and wild stoats. With this method, the blood of an animal that has consumed IPA can be tested for the presence of the foreign IPA compound itself. This is a more reliable test than the previous method, which measured the raised level of natural blood protein-bound iodine correlated with IPA absorption. The quantity of blood required from animal subjects is very small (10 μl), so the testing is less intrusive and the method can be extended to smaller species. The extraction technique uses methanol, rather than acids and heavy metal salts, thereby simplifying the procedure. Recovery of IPA is quantitative, giving a highly reliable reading. In experiments on captive rats the IPA method proved successful. Of 12 positively marked carcasses, two that had not been frozen for the 24 h before blood samples were taken showed relatively lower IPA levels. The same IPA detection method, as well as the whisker analysis for RB, was applied successfully to a population of wild stoats to which both Rhodamine B and IPA were made available at bait stations. The presence of both bait markers was detectable in rats for at least 21 days and in stoats for at least 27 days
Dynamics of ripple formation on silicon surfaces by ultrashort laser pulses in sub-ablation conditions
An investigation of ultrashort pulsed laser induced surface modification due
to conditions that result in a superheated melted liquid layer and material
evaporation are considered. To describe the surface modification occurring
after cooling and resolidification of the melted layer and understand the
underlying physical fundamental mechanisms, a unified model is presented to
account for crater and subwavelength ripple formation based on a synergy of
electron excitation and capillary waves solidification. The proposed
theoretical framework aims to address the laser-material interaction in
sub-ablation conditions and thus minimal mass removal in combination with a
hydrodynamics-based scenario of the crater creation and ripple formation
following surface irradiation with single and multiple pulses, respectively.
The development of the periodic structures is attributed to the interference of
the incident wave with a surface plasmon wave. Details of the surface
morphology attained are elaborated as a function of the imposed conditions and
results are tested against experimental data
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WH2 and proline-rich domains of WASP-family proteins collaborate to accelerate actin filament elongation.
WASP-family proteins are known to promote assembly of branched actin networks by stimulating the filament-nucleating activity of the Arp2/3 complex. Here, we show that WASP-family proteins also function as polymerases that accelerate elongation of uncapped actin filaments. When clustered on a surface, WASP-family proteins can drive branched actin networks to grow much faster than they could by direct incorporation of soluble monomers. This polymerase activity arises from the coordinated action of two regulatory sequences: (i) a WASP homology 2 (WH2) domain that binds actin, and (ii) a proline-rich sequence that binds profilin-actin complexes. In the absence of profilin, WH2 domains are sufficient to accelerate filament elongation, but in the presence of profilin, proline-rich sequences are required to support polymerase activity by (i) bringing polymerization-competent actin monomers in proximity to growing filament ends, and (ii) promoting shuttling of actin monomers from profilin-actin complexes onto nearby WH2 domains. Unoccupied WH2 domains transiently associate with free filament ends, preventing their growth and dynamically tethering the branched actin network to the WASP-family proteins that create it. Collaboration between WH2 and proline-rich sequences thus strikes a balance between filament growth and tethering. Our work expands the number of critical roles that WASP-family proteins play in the assembly of branched actin networks to at least three: (i) promoting dendritic nucleation; (ii) linking actin networks to membranes; and (iii) accelerating filament elongation
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