The importance of warehouses in logistics outsourcing: benchmarking the perspectives of 3PL providers and shippers

Purpose: An ever-increasing number of companies outsource logistics activities to third-party logistics (3PL) providers to beat the competition. From the buyer's (shippers') perspective, selecting the right 3PL provider is crucial, and from the 3PL provider's perspective, it is imperative to be attractive and to retain clients. To this aim, a potential lever can be physical assets, such as warehouses, which the literature has traditionally neglected. The objective is to benchmark the importance of warehouses for 3PL providers to attract/retain clients and for shippers to select the right 3PL provider. Design/methodology/approach: The authors performed an empirical investigation through interviews on dyads (3PL providers/shippers) and utilized the Best-Worst Method (BWM) to rank the criteria used in the 3PL buying process and allow the warehouse's role to emerge. Findings: Results show that the 3PL buying process consists of four phases and three evaluation steps. The selection criteria are classified into three groups: order qualifiers, order winners and retention factors. The warehouse has different levels of importance throughout the process. It appears that it can indirectly enhance the attractiveness and retention capability of 3PL providers through other selection criteria. Originality/value: By combining the resource-based view and the customer value theory, this research extends the theory on logistics outsourcing by studying the phases of the 3PL buying process and scrutinizing the criteria used in different evaluation steps. The research adds a double perspective of analysis (3PL providers and shippers), which is missing in the literature, and focuses on the importance of warehouses

Ku & C Band solid state switch matrix for satellite payloads using LTCC multilayer substrate

This paper describes the design and development of Ku and C band solid state switch matrix for multimedia satellite payloads. The design, through the use of advanced packaging techniques, allows significant savings on mass and volume with respect to traditional electromechanical switches while guaranteeing a comparable reliability

Securing the Post-Covid Pharma Supply Chain: An Empirical Investigation

The pandemic outbreak of Covid-19 has shown the fragilities and vulnerabilities of the Pharma Supply Chain (PSC), leading academics and practitioners to rethink PSCs’ flexibility, agility, responsiveness, and resilience. This paper investigates how to secure the Post-Covid PSC by (i) classifying the challenges born of or aggravated by the pandemic; (ii) understanding how solutions enabled by Industry 4.0 technologies can be integrated into a framework to address and solve the above challenges. A theoretical framework was developed from a literature review to achieve these objectives, which was then confirmed and enriched by a multiple case study investigation

An empirical analysis of supply and manufacturing risk and business performance: A Chinese manufacturing supply chain perspective

Purpose – This study explores the importance and impact of supply and manufacturing risk management upon business performance within the context of Chinese manufacturing supply chains. Design/Methodology/Approach – A two phased multi-method approach was adopted, which included a survey questionnaire to practitioners in Chinese manufacturing supply chains followed by semi-structured interviews. The findings included 103 valid survey responses complemented by six semi-structured interviews. Findings – The results indicate that in Chinese manufacturing context supply risk and manufacturing risk management are both vital for business performance. A high correlation between business and manufacturing risk management performance exists, however no significant impact of supplier dependency, systematic purchasing, maturity of production and supply chain, and human resources was found despite previously these elements being regarded as key influencers for supply and manufacturing risk management performance. The Chinese manufacturing supply chain indicated that elements such as the supplier and customer orientation, flexibility, manufacturing and supply risk highly connotes with business performance. Theoretical/Practical implications – In the current unpredictable and volatile business environment the competitiveness of manufacturing supply chains to a large extent depend on their ability to identify, assess and manage the manufacturing and supply risks. The findings of this study will assist supply chain managers in taking decision on manufacturing and supply risk management and reducing the uncertainty upon their business performance. Originality/value – The supply chain risk has been widely explored within the context of individual case studies, or standalone models focusing on either supply or manufacturing risk in supply chains, however to what extent this has been applicable to a wider context and its impact upon business process has not been explored. Hence, this study simultaneously has analysed manufacturing risk and supply risk and its impact upon Chinese manufacturing supply chains business performance. Moreover, this study uses a combination of quantitative and qualitative methods, which is often limited in this area. Finally, the institutional theory lens offers novel insights in better understanding the factors that can affect the impact of supply and manufacturing risk management upon business performance in those contexts, such as China, where the institutional aspect presents specific features

Supply chain simulation in a Big Data context: risks and uncertainty analysis

Due to their complex and dynamic nature, Supply Chains are prone to risks that may occur at any time and place. To tackle this problem, simulation can be used. However, such models should use Big Data technologies, in order to provide the level of data and detail contained in the data sources associated to the business processes. In this regard, this paper considered a real case of an automotive electronics Supply chain. Hence, the purpose of this paper is to propose a simulation tool, which uses real industrial data, provided by a Big Data Warehouse, and use such decision-support artifact to test different types of risks. More concretely, risks in the supply and demand end of the network are analyzed. The presented results also demonstrate the possible benefits that can be achieved by using simulation in the analysis of risks in a Supply Chain.This work has been supported by FCT–Fundação para a Ciência e Tec-nologia within the Project Scope: UID/CEC/00319/2019 and by the Doctoral scholarship PDE/BDE/114566/2016 funded by FCT, the Portuguese Ministry of Science, Technology andHigher Education, through national funds, and co-financed by the European Social Fund(ESF) through the Operational Programme for Human Capital (POCH)

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects, the pathogenesis of which still remains poorly understood. In particular, NBS1 gene mutations are associated with microcephaly and strongly impaired cerebellar development, both in humans and in the mouse model. These phenotypes strikingly overlap those induced by inactivation of MYCN, an essential promoter of the expansion of neuronal stem and progenitor cells, suggesting that MYCN and the MRN complex might be connected on a unique pathway essential for the safe expansion of neuronal cells. Here, we show that MYCN transcriptionally controls the expression of each component of the MRN complex. By genetic and pharmacological inhibition of the MRN complex in a MYCN overexpression model and in the more physiological context of the Hedgehog-dependent expansion of primary cerebellar granule progenitor cells, we also show that the MRN complex is required for MYCN-dependent proliferation. Indeed, its inhibition resulted in DNA damage, activation of a DNA damage response, and cell death in a MYCN- and replication-dependent manner. Our data indicate the MRN complex is essential to restrain MYCN-induced replication stress during neural cell proliferation and support the hypothesis that replication-born DNA damage is responsible for the neuronal defects associated with MRN dysfunctions.Cell Death and Differentiation advance online publication, 12 June 2015; doi:10.1038/cdd.2015.81