El mundo lazarillesco de los procesos de pesquisas: muestras del archivo catedralicio de Oviedo

Buena parte de la crítica reciente del Lazarillo se ha enfocado en el empleo de una especie de ironía autorial que les obliga a los lectores mismos evaluar la fiabilidad del narrador. Como modelo se ha sugerido los relatos escritos por clérigos en su propia defensa al abrirse una investigación de su conducta. Unos críticos habían notado la abundancia de tales documentos en el archivo catedralicio ovetense. Muestras de la riqueza narrativa allí disponible no han producido ningún paralelo con la implícita carta que inicia la explicación de la mala conducta del narrador, pero las estrategias de ocultación y auto-justificación, como también muchas de las mismas ofensas presentadas en la novela, son prácticamente ubicuas y pueden aportado mucho al tono de la picaresca literaria

Gene Therapy for the Treatment of Equine Osteoarthritis

Osteoarthritis (OA) is the predominant cause of lameness in horses. As in humans, the clinical symptoms of equine OA are persistent pain and dysfunction of the affected joint. Its pathology is similarly marked by progressive deterioration of the articular cartilage, subchondral bone sclerosis, marginal osteophytes, soft tissue inflammation and joint effusion. Disease pathogenesis is mediated by elevated levels of inflammatory cytokines and proteolytic enzymes in the articular tissues and synovial fluid. Existing pharmacologic agents can alleviate OA joint pain; none are able to inhibit erosive disease progression. As several gene-based treatments for human disease have received approval by the Food and Drug Administration (FDA), the transition to veterinary medicine will almost certainly follow. Several viral vector systems have demonstrated highly efficient gene transfer to the equine joint, enabling expression of therapeutic transgenes at efficacious levels for well over a year. Because of its large size, the equine joint is well suited to studies of gene-based therapies for arthritic disease. The forelimb joints are vulnerable to OA onset, and treatment and diagnostic modalities are the same in humans and horses. Here, we discuss the various gene-transfer approaches under investigation and the current progress toward the development an effective gene therapy for equine OA

Parents dealing with anorexia : actions and meanings

This paper examines parents&rsquo; actions in response to anorexia nervosa, and how these are shaped by the ways they construct or understand the eating disorder. The findings indicate that parents try to influence their daughters by searching for help, providing practical support, avoiding confrontation, complying with special requirements, persuading, explaining, and pressuring, using ploys and force, providing emotional support, and mediating interactions. Parents&rsquo; actions are influenced by how they construct anorexia, such as whether they see it as an eating issue, an illness, a psychological problem, a choice, or a mystery. Understanding parents&rsquo; actions and constructions can help clinicians develop collaborative partnerships with parents.<br /

The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species