Quantum Fluctuations of Radiation Pressure

Quantum fluctuations of electromagnetic radiation pressure are discussed. We use an approach based on the quantum stress tensor to calculate the fluctuations in velocity and position of a mirror subjected to electromagnetic radiation. Our approach reveals that radiation pressure fluctuations are due to a cross term between vacuum and state dependent terms in a stress tensor operator product. Thus observation of these fluctuations would entail experimental confirmation of this cross term. We first analyze the pressure fluctuations on a single, perfectly reflecting mirror, and then study the case of an interferometer. This involves a study of the effects of multiple bounces in one arm, as well as the correlations of the pressure fluctuations between arms of the interferometer. In all cases, our results are consistent with those previously obtained by Caves using different mehods.Comment: 23 pages, 3 figures, RevTe

Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids, austinol and dehydroaustinol in Aspergillus nidulans

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/ja209809t.Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level should facilitate engineering of second-generation molecules and increasing production of first-generation compounds. The filamentous fungus Aspergillus nidulans has previously been found to produce two meroterpenoids, austinol and dehydroaustinol. Using targeted deletions that we created, we have determined that, surprisingly, two separate gene clusters are required for meroterpenoid biosynthesis. One is a cluster of four genes including a polyketide synthase gene, ausA. The second is a cluster of ten additional genes including a prenyltransferase gene, ausN, located on a separate chromosome. Chemical analysis of mutant extracts enabled us to isolate 3,5-dimethylorsellinic acid and ten additional meroterpenoids that are either intermediates or shunt products from the biosynthetic pathway. Six of them were identified as novel meroterpenoids in this study. Our data, in aggregate, allow us to propose a complete biosynthetic pathway for the A. nidulans meroterpenoids

Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin

Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily

Quantum Stress Tensor Fluctuations of a Conformal Field and Inflationary Cosmology

We discuss the additional perturbation introduced during inflation by quantum stress tensor fluctuations of a conformally invariant field such as the photon. We consider both a kinematical model, which deals only with the expansion fluctuations of geodesics, and a dynamical model which treats the coupling of the stress tensor fluctuations to a scalar inflaton. In neither model do we find any growth at late times, in accordance with a theorem due to Weinberg. What we find instead is a correction which becomes larger the earlier one starts inflation. This correction is non-Gaussian and highly scale dependent, so the absence of such effects from the observed power spectra may imply a constraint on the total duration of inflation. We discuss different views about the validity of perturbation theory at very early times during which currently observable modes are transplanckian.Comment: 31 pages, 1 figure, uses LaTeX2epsilo

The Possible Neuronal Mechanism of Acupuncture: Morphological Evidence of the Neuronal Connection between Groin A-Shi Point and Uterus

Somatovisceral reflex suggested that the somatic stimulation could affect visceral function like acupuncture which treats diseases by stimulating acupoints. The neuronal connection between somatic point and visceral organ was not clear. Uterine pain referred to the groin region has long been recognized clinically. Wesselmann, using neurogenic plasma extravasation method, showed that uterine pain was referred to the groin region through a neuronal mechanism (Wesselmann and Lai 1997). This connection could be considered through the somatovisceral reflex pathway. However, the relay center of this pathway is still not clearly identified. In the present study, bee venom was injected in the groin region to induce central Fos expression to map the sensory innervation of groin region. Pseudorabies virus (PrV), a transneuronal tracer, was injected in the uterus to identify the higher motor control of the uterus. Immunohistochemistry staining revealed the Fos expression and PrV-infected double-labeled neurons in the nucleus of solitary tract (NTS), the dorsal motor nucleus of vagus (DMX), and the paraventricular hypothalamic nucleus (PVN). These results suggest a somatoparasympathetic neuronal connection (groin-spinal dorsal horn-NTS/DMX-uterus) and a somatosympathetic neuronal connection (groin-spinal dorsal horn-NTS-PVN-uterus). These two neuronal connections could be the prerequisites to the neuronal basis of the somatovisceral reflex and also the neuronal mechanism of acupuncture

Fluctuations of the Retarded Van der Waals Force

The retarded Van der Waals force between a polarizable particle and a perfectly conducting plate is re-examined. The expression for this force given by Casimir and Polder represents a mean force, but there are large fluctuations around this mean value on short time scales which are of the same order of magnitude as the mean force itself. However, these fluctuations occur on time scales which are typically of the order of the light travel time between the atom and the plate. As a consequence, they will not be observed in an experiment which measures the force averaged over a much longer time. In the large time limit, the magnitude of the mean squared velocity of a test particle due to this fluctuating Van der Waals force approaches a constant, and is similar to a Brownian motion of a test particle in an thermal bath with an effective temperature. However the fluctuations are not isotropic in this case, and the shift in the mean square velocity components can even be negative. We interpret this negative shift to correspond to a reduction in the velocity spread of a wavepacket. The force fluctuations discussed in this paper are special case of the more general problem of stress tensor fluctuations. These are of interest in a variety of areas fo physics, including gravity theory. Thus the effects of Van der Waals force fluctuations serve as a useful model for better understanding quantum effects in gravity theory.Comment: 14 pages, no figure

Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial

Objective. This study was to evaluate the efficacy and safety of a Chinese herbal medicine formula (RCM-104) for the management of simple obesity. Method. Obese subjects aged between 18 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial. Subjects were randomly assigned to take 4 capsules of either the RCM-104 formula (n = 59) or placebo (n = 58), 3 times daily for 12 weeks. Measures of BW, BMI and WC, HC, WHR and BF composition were assessed at baseline and once every four weeks during the 12 week treatment period. Results. Of the 117 subjects randomised, 92 were included in the ITT analysis. The weight, BMI and BF in RCM-104 group were reduced by 1.5 kg, 0.6 kg/m2 and 0.9% and those in the placebo group were increased by 0.5 kg, 0.2 kg/m2 and 0.1% respectively. There were significant differences in BW and BMI (P < 0.05) between the two groups. Eleven items of the WLQOQ were significantly improved in the RCM-104 group while only 2 items were significantly improved in the placebo group. Adverse events were minor in both groups. Conclusion. RCM-104 treatment appears to be well tolerated and beneficial in reducing BW and BMI in obese subjects

Illuminating the diversity of aromantic polyketide synthases in Aspergillus nidulans

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/ja3016395.Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy that bypasses normal regulatory mechanisms. By efficient gene targeting, we have replaced, en masse, the promoters of non-reducing polyketide synthase (NR-PKS) genes, key genes in NP biosynthetic pathways and other genes necessary for NR-PKS product formation or release. This has allowed us to determine the products of eight NR-PKSs of A. nidulans, including seven novel compounds, as well as the NR-PKS genes required for the synthesis of the toxins, alternariol (8) and cichorine (19)

Quantum Stress Tensor Fluctuation Effects in Inflationary Cosmology

We review several related investigations of the effects of the quantum stress tensor of a conformal field in inflationary cosmology. Particular attention will be paid to the effects of quantum stress tensor fluctuations as a source of density and tensor perturbations in inflationary models. These effects can possibly depend upon the total expansion factor during inflation, and hence be much larger than one might otherwise expect. They have the potential to contribute a non-scale invariant and non-Gaussian component to the primordial spectrum of perturbations, and might be observable.Comment: 8 pages, proceedings of IARD 2010, Conference on Classical and Quantum Relativistic Dynamics of Particles and Fields, Hualien, Taiwan May 201