Tamsulosin-induced acute liver injury: a case report

International audienceMeeting Abstract: PS-052, 20e congrès de la Société Française de Pharmacologie et de Thérapeutique, Nancy, 19-21 avril 201

Évaluation des délais de guérison des ostéochimionécroses des maxillaires après traitement chirurgical : étude rétrospective monocentrique et revue de la littérature

International audienc

3R gene expression in chronic lymphocytic leukemia reveals insight into disease evolution

International audienc

Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses

BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to RAF and MEK inhibitors could be categorized upon specific features of the fusion kinases. Higher expression level correlated with resistance, and fusion partners containing a dimerization domain promoted paradoxical activation of the mitogen-activated protein kinase (MAPK) pathway and hyperproliferation in response to first- and second-generation RAF inhibitors. By contrast, next-generation αC-IN/DFG-OUT RAF inhibitors blunted paradoxical activation across all lines and had their therapeutic efficacy further increased in vitro and in vivo by combination with MEK inhibitors, opening perspectives in the clinical management of tumors harboring BRAF fusions