On homogeneous CR manifolds and their CR algebras

In this paper we show some results on homogeneous CR manifolds, proved by introducing their associated CR algebras. In particular, we give different notions of nondegeneracy (generalizing the usual notion for the Levi form) which correspond to geometrical properties for the corresponding manifolds. We also give distinguished equivariant CR fibrations for homogeneous CR manifolds. In the second part of the paper we apply these results to minimal orbits for the action of a real form of a semisimple Lie group \^G on a flag manifold \^G/Q.Comment: 14 pages. AMS-LaTeX v2: minor revisio

Rickettsial pathogens and their arthropod vectors.

Rickettsial diseases, important causes of illness and death worldwide, exist primarily in endemic and enzootic foci that occasionally give rise to sporadic or seasonal outbreaks. Rickettsial pathogens are highly specialized for obligate intracellular survival in both the vertebrate host and the invertebrate vector. While studies often focus primarily on the vertebrate host, the arthropod vector is often more important in the natural maintenance of the pathogen. Consequently, coevolution of rickettsiae with arthropods is responsible for many features of the host-pathogen relationship that are unique among arthropod-borne diseases, including efficient pathogen replication, long-term maintenance of infection, and transstadial and transovarial transmission. This article examines the common features of the host-pathogen relationship and of the arthropod vectors of the typhus and spotted fever group rickettsiae

A Spectrum of Audience Interactivity for entertainment domains

The concept of audience interactivity has been rediscovered across many domains of storytelling and entertainment—e.g. digital games, in-person role-playing, film, theater performance, music, and theme parks—that enrich the form with new idioms, language, and practices. In this paper, we introduce a Spectrum of Audience Interactivity that establishes a common vocabulary for the design space across entertainment domains. Our spectrum expands on an early vocabulary conceptualized through co-design sessions for interactive musical performances. We conduct a cross-disciplinary literature review to evaluate and iterate upon this vocabulary, using our findings to develop our validated spectrum

Asymptotic Behaviour of the Proper Length and Volume of the Schwarzschild Singularity

Though popular presentations give the Schwarzschild singularity as a point it is known that it is spacelike and not timelike. Thus it has a "length" and is not a "point". In fact, its length must necessarily be infinite. It has been proved that the proper length of the Qadir-Wheeler suture model goes to infinity [1], while its proper volume shrinks to zero, and the asymptotic behaviour of the length and volume have been calculated. That model consists of two Friedmann sections connected by a Schwarzschild "suture". The question arises whether a similar analysis could provide the asymptotic behaviour of the Schwarzschild black hole near the singularity. It is proved here that, unlike the behaviour for the suture model, for the Schwarzschild essential singularity $\Delta s$ $\thicksim$ $K^{1/3}\ln K$ and $V\thicksim$ $K^{-1}\ln K$, where $K$ is the mean extrinsic curvature, or the York time.Comment: 13 pages, 1 figur

Framework for better living with HIV in England

Duration: April 2007 - May 2009 Sigma Research was funded by Terrence Higgins Trust to co-ordinate the development of a framework to address the health, social care, support and information needs of people with diagnosed HIV in England. It has now been published as the Framework for better living with HIV in England. The over-arching goal of the framework is that all people with diagnosed HIV in England "are enabled to have the maximum level of health, well-being, quality of life and social integration". In its explanation of how this should occur the document presents a road map for social care, support and information provision to people with diagnosed HIV in England. By establishing and communicating aims and objectives, the framework should build consensus and provide a means to establish how interventions could be prioritised and coordinated. The key drivers for the framework were clearly articulated ethical principles, agreed by all those who sign up to it, and an inclusive social development / health promotion approach. Sigma Research worked on the framework with a range of other organisations who sent representatives to a Framework Development Group (see below for membership). The framework is evidence-based and seeks to: Promote and protect the rights and well-being of all people with HIV in England. Maximise the capacity of individuals and groups of people with HIV to care for, advocate and represent themselves effectively. Improve and protect access to appropriate information, social support, social care and clinical services. Minimise social, economic, governmental and judicial change detrimental to the health and well being of people with HIV. Alongside the development of the framework, Sigma Research undertook a national needs assessment among people with diagnosed HIV across the UK called What do you need?. These two projects informed and supported each other. Framework Development Group included: African HV Policy Network Black Health Agency George House Trust NAM NAT (National AIDS Trust) Positively Women Terrence Higgins Trus

Prevalence and etiology of hearing impairment in urban area of Shimla, Himachal Pradesh, India: a cross sectional observational study

Background: The ear is a marvelously complex and sensitive organ. Disease of the ear have profound effect on the health and quality of life of millions of people around the globe. Data regarding the magnitude of hearing impairment in our country is limited and the literature search revealed that no such studies have been conducted in this region.Methods: A community based cross sectional observational study was carried out among the 306 individuals in urban area of Shimla, Himachal Pradesh, India. Information was obtained by a structured questionnaire, clinical ENT examination and audiological tests after obtaining informed consent.Results: The study group had 48.4% males and 51.6% females. Maximum 29.4% of individuals were in the age group of 31-45 years. Mean age was 32.22±20.15. The prevalence of hearing impairment was 13.1%. Among individuals with hearing loss, maximum 57.5% were in the age group of ≥60 years. Sensorineural hearing loss was found in 70%, maximum 55% had mild hearing loss. Among majority of individuals with hearing loss cause was presbyacusis 57.5% followed by infectious ear disease 27.5%. Among majority of individuals with hearing loss 37.5% required no further action at the time of study.Conclusions: In the present study, prevalence of hearing loss was found to be 13.1% and predominantly mild sensorineural or conductive type of hearing loss. An early intervention and quality patient education was necessary for prevention of hearing impairment in majority of cases

Generalization of entropy based divergence measures for symbolic sequence analysis

Entropy based measures have been frequently used in symbolic sequence analysis. A symmetrized and smoothed form of Kullback-Leibler divergence or relative entropy, the Jensen-Shannon divergence (JSD), is of particular interest because of its sharing properties with families of other divergence measures and its interpretability in different domains including statistical physics, information theory and mathematical statistics. The uniqueness and versatility of this measure arise because of a number of attributes including generalization to any number of probability distributions and association of weights to the distributions. Furthermore, its entropic formulation allows its generalization in different statistical frameworks, such as, non-extensive Tsallis statistics and higher order Markovian statistics. We revisit these generalizations and propose a new generalization of JSD in the integrated Tsallis and Markovian statistical framework. We show that this generalization can be interpreted in terms of mutual information. We also investigate the performance of different JSD generalizations in deconstructing chimeric DNA sequences assembled from bacterial genomes including that of E. coli, S. enterica typhi, Y. pestis and H. influenzae. Our results show that the JSD generalizations bring in more pronounced improvements when the sequences being compared are from phylogenetically proximal organisms, which are often difficult to distinguish because of their compositional similarity. While small but noticeable improvements were observed with the Tsallis statistical JSD generalization, relatively large improvements were observed with the Markovian generalization. In contrast, the proposed Tsallis-Markovian generalization yielded more pronounced improvements relative to the Tsallis and Markovian generalizations, specifically when the sequences being compared arose from phylogenetically proximal organisms.publishedVersionFil: Ré, Miguel Ángel. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Informática para la Ingeniería. Departamento de Ciencias Básicas; Argentina.Fil: Ré, Miguel Ángel. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Azad, Rajeev K. University of North Texas. College of Science. Department of Biological Sciences; Estados Unidos de América.Fil: Azad, Rajeev K. University of North Texas. College of Science. Department of Mathematics; Estados Unidos de América.Ciencias de la Información y Bioinformática (desarrollo de hardware va en 2.2 "Ingeniería Eléctrica, Electrónica y de Información" y los aspectos sociales van en 5.8 "Comunicación y Medios"

miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain

Background: Accumulating evidence indicates that neuropathic pain is a neuro-immune disorder with enhanced activation of the immune system. Recent data provided proof that neuropathic pain patients exhibit increased numbers of immunosuppressive regulatory T cells (Tregs), which may represent an endogenous attempt to limit inflammation and to reduce pain levels. We here investigate the molecular mechanisms underlying these alterations. Methods: Our experimental approach includes functional analyses of primary human T cells, 3'-UTR reporter assays, and expression analyses of neuropathic pain patients' samples. Results: We demonstrate that microRNAs (miRNAs) are involved in the differentiation of Tregs in neuropathic pain. We identify miR-124a and miR-155 as direct repressors of the histone deacetylase sirtuin1 (SIRT1) in primary human CD4+ cells. Targeting of SIRT1 by either specific siRNA or by these two miRNAs results in an increase of Foxp3 expression and, consecutively, of anti-inflammatory Tregs (siRNA: 1.7 +/- 0.4;miR-124a: 1.5 +/- 0.4;miR-155: 1.6 +/- 0.4;p < 0.01). As compared to healthy volunteers, neuropathic pain patients exhibited an increased expression of miR124a (2.5 +/- 0.7, p < 0.05) and miR-155 (1.3 +/- 0.3;p < 0.05) as well as a reduced expression of SIRT1 (0.5 +/- 0.2;p < 0.01). Moreover, the expression of these two miRNAs was inversely correlated with SIRT1 transcript levels. Conclusions: Our findings suggest that in neuropathic pain, enhanced targeting of SIRT1 by miR-124a and miR-155 induces a bias of CD4(+) T cell differentiation towards Tregs, thereby limiting pain-evoking inflammation. Deciphering miRNA-target interactions that influence inflammatory pathways in neuropathic pain may contribute to the discovery of new roads towards pain amelioration

Emerging evidence for CHFR as a cancer biomarker : from tumor biology to precision medicine

Novel insights in the biology of cancer have switched the paradigm of a "one-size-fits-all" cancer treatment to an individualized biology-driven treatment approach. In recent years, a diversity of biomarkers and targeted therapies has been discovered. Although these examples accentuate the promise of personalized cancer treatment, for most cancers and cancer subgroups no biomarkers and effective targeted therapy are available. The great majority of patients still receive unselected standard therapies with no use of their individual molecular characteristics. Better knowledge about the underlying tumor biology will lead the way toward personalized cancer treatment. In this review, we summarize the evidence for a promising cancer biomarker: checkpoint with forkhead and ring finger domains (CHFR). CHFR is a mitotic checkpoint and tumor suppressor gene, which is inactivated in a diverse group of solid malignancies, mostly by promoter CpG island methylation. CHFR inactivation has shown to be an indicator of poor prognosis and sensitivity to taxane-based chemotherapy. Here we summarize the current knowledge of altered CHFR expression in cancer, the impact on tumor biology and implications for personalized cancer treatment