The second workshop on Child-Centred AI design (CCAI)

AI-powered solutions are increasingly woven into the fabric of children’s digital worlds. They’re found in interactive toys, home automation systems, everyday apps, and various online services that young users engage with. As we look ahead, it’s almost certain that the prevalence of AI in tools and platforms designed for kids will grow, given AI’s ability to offer rich, tailored, and dynamic experiences. However, the nuances of how these AI-centric platforms cater to children and how they can be optimized to meet the unique needs of younger users remain largely underexplored. Building on the momentum from our inaugural CCAI workshop at CHI 2023, our aspirations for this year’s workshop include: (1) deepening the discourse on the essence of AI that prioritizes children, (2) focusing on actionable strategies to operationalise child-centered AI design principles into practice, and (3) cultivating an ever-growing collective of professionals passionate about the future of child-focused AI innovations

Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion

WOS: 000264914000001PubMed ID: 19239691Turkish Scientific and Technological Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-107S026]; Dokuz Eylul University Research FoundationDokuz Eylul University [05.KB.SAG.071]We thank Prof. Mehmet Ozturk for providing us HCC cell lines and for his critical reading of the manuscript; and Prof. Aykut Uren for his helpful discussions on the manuscript. We also thank to Evin Ozen for her technical assistance. This work was supported by grants to Nese ATABEY from the Turkish Scientific and Technological Research Council (TUBITAK, SBAG-107S026) and Dokuz Eylul University Research Foundation (05.KB.SAG.071)

Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents

Aberrant signaling through protein-tyrosine kinase (PTK)-dependent pathways is associated with several proliferative diseases. Accordingly, PTK inhibitors are being developed as new approaches for the treatment of certain cancers. Growth factor receptor bound protein 2 (Grb2) is an important downstream mediator of PTK signaling that serves obligatory roles in many pathogenic processes. One of the primary functions of Grb2 is to bind to specific phosphotyrosyl (pTyr)-containing sequences through its Src homology 2 (SH2) domain. Agents that bind to the Grb2 SH2 domain and prevent its normal function could disrupt associated PTK signaling and serve as alternatives to kinase-directed inhibitors. Starting from the X-ray crystal structure of a lead peptide bound to the Grb2 SH2 domain, this review will summarize important contributions to these efforts. The presentation will be thematically arranged according to the region of peptide modified, proceeding from the N-terminus to the C-terminus, with a special section devoted to aspects of conformational constraint

An anatomical study of the inferior cubital artery

The inferior cubital artery is important in planning fasciocutaneous flaps in the forearm. The origin, course, anatomical relationships, and diameter were investigated in 20 human cadavers by dissecting 40 arms. The anatomical architecture of the artery was classified into six groups according to their origin, either being from the radial or the radial recurrent or the brachial artery. The skin marking of the origin of the inferior cubital artery was determined to be 38.55+/-11.57 mm (mean+/-1 SD) inferior to the midpoint of the interepicondylar line on the anterior surface of the forearm. The inferior cubital artery may course from the back (70%), the front (17.5%), or between the paired limbs (5%) of the communicating branch of the cephalic vein in a crosswise fashion. The mean diameter of the artery was found to be 1.08+/-0.34 mm (mean+/-1 SD). We report the observation of three new variations and different courses of the inferior cubital artery that have not been previously reported

Endoscopic carpal tunnel release using the biportal technique

The clinical study consisted of 27 patients and 30 hands that were operated on with the biportal endoscopic carpal tunnel release technique between 2000 and 2002. The mean follow-up time was 28 months. The time to return to work or complete recovery was found to average 12 days. The rate of functional recovery was 93% (27 hands), and 90% of hands (26 hands) were free of symptoms at the time of publication. According to our study, we conclude that the biportal endoscopic technique is an effective method to attain patient comfort; it is a minimally invasive method with a low complication rate in experienced hands for surgical treatment of carpal tunnel syndrome. Military persons can return to work quickly, without deficits in hand skills, with the use of this technique

Surgical treatment for ischial pressure sores with gracilis myocutaneous flap.

Surgical reconstruction of ischial pressure sores is technically complex and presents a significant problem. Although there is consensus about the use of muscle or myocutaneous flaps in the closure of these sores, there is still dispute about which muscle or myocutaneous flap to use. This evaluation describes the use of the gracilis myocutaneous flap for the treatment of wide and chronic ischial pressure sores. Details of 14 cases are presented and compared with those described in the literature

Treatment of temporomandibular joint ankylosis with inverted T-shaped silicone implants

A new technique for the functional reconstruction of the ankylotic temporomandibular joint (TMJ) is presented. Interposition of a custom-made inverted T-shape silicone implant after osteotomy of the condylar neck has given good results. A case is presented and the advantages of the method are discussed

Effects of basic fibroblast factor (bFGF) on MMP-2, TIMP-2, and type-I collagen levels in human lung carcinoma fibroblasts

Matrix metalloproteinases (MMP's) and tissue inhibitors of metalloproteinases (TIMP's) possess a preponderant role in the metabolism of the major extracellular matrix protein, collagen, and are thought to be important in the mechanism of tumor invasion. Lung cancer occupies the first position in mortality and the second position in incidence, among all cancers. In the present investigation, we studied the effect of basic fibroblast growth factor (bFGF) on collagen, matrix metalloproteinase-2 (MMP-2), and tissue metalloproteinase inhibitor-2 (TIMP-2) levels in normal and carcinoma lung tissue fibroblast cultures. MMP-2 was selected because of its high specificity in the degradation of type IV collagen, major component of the basal membrane. The effect of bFGF on MMP-2, TIMP-2, total collagen, and type I collagen levels of normal and carcinoma lung fibroblast cultures was investigated at 0, 10, and 100 ng/ml. Statistical analysis was carried out using the Mann-Whitney-U test and possible correlations were searched using the Spearman correlation analysis method. MMP-2, TIMP-2, total collagen, and type-1 collagen levels based on cell counts (10(3) cells) showed no statistically significant differences between the carcinoma and normal fibroblast cultures. However, positive correlations were found between MMP-2 and TIMP-2 in normal (P = 0.016) and carcinoma (P = 0.001) tissue fibroblast cultures. Positive correlations were also found between total collagen and TIMP-2 levels in normal and carcinoma tissue fibroblast cultures (P = 0.002 and P = 0.032). Total collagen and TIMP-2 levels also showed positive and strong correlations in all cultures except in 100 ng/ml bFGF concentrations. In addition, type I collagen and MMP-2 levels showed positive significant correlations only in normal and carcinoma control cultures, while type I collagen and TIMP-2 levels showed positive correlations in all cultures except carcinoma fibroblasts at 100 ng/ml bFGF. It may be concluded that bFGF does not affect MMP-2, TIMP-2, total collagen, and type-1 collagen levels in fibroblast cultures grown from human carcinoma and normal lung tissues. However, bFGF was noted, in vitro, to disturb the equilibrium which normally exists between the four parameters, both in normal and carcinoma tissue fibroblasts. (c) 2005 Elsevier SAS. All rights reserved