Cancer chemotherapy and liver [Kanser kemoterapisi ve karaciger]

The potential hepatotoxicity from cancer chemotherapy may be complex. Liver injury during cancer chemotherapy may not always reflect hepatotoxic anticancer drugs; the clinician must also consider reactions to antibiotics, analgesic, antiemetic other medications. Preexisting medical problems, tumor, immumosuppression, hepatitis viruses and other infections and nutrition deficiencies all may affect a host susceptibility to liver injury. Drugs that commonly produce hepatotoxicity are L-asparaginase, methotrexate, cytrabine, 6-thiopurines and mitramycin. The review discusses the effect of chemotherapeutic agents on the liver

Ulcerative colitis and thrombosis [Ülseratif kolit ve tromboz]

Inflammatory bowel disease (IDB) is systemic disorder. An increased risk of arterial and venous thrombosis was originally reported by Borgen and Barker in 1936. Clinically, it is seen only 1-3% of patients admitted to the hospital for IBD. Ulcerative colitis may be complicated by macrovascular thrombosis. The most common manifestations are deep vein thrombosis of the leg and pulmonary emboli. Several mechanisms have been described which might explain an increased tendency for thromboembolic events in patients with IBD. Genetic risk factors for venous thrombosis are classified as deficiencies of protein C, protein S, antitrombin III, factor V leiden and protrombin 20210, hyperhomocysteinemia

A novel version of Copenhagen Psychosocial Questionnaire-3: Turkish validation study

Purpose: The aim of the study was to adapt the Copenhagen Psychosocial Questionnaire Version-3 (COPSOQ-3) into the Turkish language. Methods: This is a methodologic study. The field study occurred in four workplaces (call center, hospital, plastic and metal industries). The Kaiser-Meyer-Olkin (KMO) Measure of Sampling Adequacy and Bartlett's Test of Sphericity were used to assess the suitability of the sample for factor analysis. The principal component analysis and varimax rotation methods were used to identify the factor structure.The internal consistency was assessed using the Cronbach's alpha coefficient. Results: In total, 1076 respondents' questionnaires were evaluated. Fifty-eight percent of the participants were men and the mean age was 31.1 ± 7.7. Sampling adequacy was considered adequate (KMO =0.929). The factor analysis of the Turkish COPSOQ (COPSOQ-TR) identified 19 factors with eigenvalues higher than one and explained 66.1% of the total variance. The Cronbach's alpha values of 23 dimensions were over 0.70. The Cronbach's alpha values of control over working time and predictability were 0.54 and 0.66, respectively. The model was an excellent fit (Chi-Square = 8514.5, x2/df = 2.48, RMSEA = 0.038, SRMR = 0.053, CFI = 0.98). Conclusions: Findings show that COPSOQ-TR is a reliable and valid instrument that can be a useful tool to measure psychosocial risks in the Turkish language. © 2018, © 2018 Taylor & Francis Group, LLC

High-Intensity Small-Sided Games versus Repeated Sprint Training in Junior Soccer Players

The aim of this study was to compare the effects of high-intensity small-sided games training (SSGT) versus repeated-sprint training (RST) on repeated-sprint ability (RSA), soccer specific endurance performance and short passing ability among junior soccer players. The junior soccer players were recruited from of a professional team (age 16.9 ± 1.1 years). The tests included the repeated-shuttle-sprint ability test (RSSAT), Yo-Yo Intermittent Recovery Test level 1 (Yo-Yo IR1) and Loughborough Soccer Passing Test (LSPT). Nineteen participants were randomly assigned to either the small-sided games training (SSGTG) (n = 10) or repeated-sprint training group (RSTG) (n = 9). Small-sided games or repeated-sprint training were added to the regular training sessions for two days of the regular practice week. The Wilcoxon signed-rank and Mann-Whitney U tests were used to examine differences in groups and training effects. A time x training group effect was found in the improvement of short-passing ability for the smallsided games training group which showed significantly better scores than the repeated-sprint training group (p ≤ 0.05). Both groups showed similar improvements in RSAdecrement (p < 0.05). Only the repeated-sprint training group improved in the Yo-Yo IR1 (p < 0.05). This study clearly shows that high-intensity small-sided games training can be used as an effective training mode to enhance both repeated sprint ability and short-passing ability. © 2017 Editorial Committee of Journal of Human Kinetics 2017

Unconventional experimental technologies available for phase change materials (PCM) characterization. Part 1. Thermophysical properties

The use of thermal energy storage by phase change materials (PCM) is increasing in interest for building applications. For the deployment of the technology, appropriate characterization of PCM and hybrid PCM is essential, but it is not always possible to carry it out with conventional equipment, mainly due to the sample size. This paper shows equipment developed in different research centers and universities to analyze thermophysical properties, such as specific heat, latent heat and melting temperature, and thermal conductivity and diffusivity of PCM and hybrid PCM materials. © 2014 Elsevier Ltd.ENE2011-28269-C03-01, ENE2011-22722, ENE2011-28269-C03-02 European Commission 110M032 Qatar Foundation: BES-2012–051861 COST TU0802The work is partially funded by the European Union (COST Action COST TU0802 ), the Spanish government ( ENE2011-28269-C03-01 , ENE2011-28269-C03-02 and ENE2011-22722 ), TUBITAK (project 110M032 ), and by Qatar National Foundation through the NPRP No.: 4–465-2–173 . The authors would like to thank the Catalan Government for the quality accreditation given to the research group GREA ( 2014 SGR 123 ) and their research group DIOPMA (2014 SGR 1543), both in Spain. Laia Miró would like to thank the Spanish Government for her research fellowship ( BES-2012–051861 )