Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

ACUTE AND SUBACUTE TOXICITY STUDIES OF ETHANOLIC EXTRACT OF MIRABILIS JALAPA LINN IN WISTAR ALBINO RATS

Objective: The objective of the study was to evaluate the toxicological potential of the ethanolic extract of leaves of Mirabilis jalapa linn through acute and subacute toxicity studies in albino Wistar rats. Methods: For acute toxicity studies, the ethanolic extract of M. jalapa was given up to 2000 mg/kg and then the animals were observed for 14 days to find out any adverse effect or death. For sub-acute toxicity studies, the exact was given for 28 days and the following parameters were observed such as changes in body weight, food intake, water intake, hematological parameters, biochemical parameters, lipid profile, urine analysis, and histopathological studies were undertaken. Results: Single oral administration of 2000 mg/kg of the ethanolic extract of M. jalapa produced no mortality or signs of toxicity. During subacute toxicity there were no changes in body weight, food intake and water intake were observed. There were no changes in lipid profile, hematological parameters, and biochemical parameters. In histopathological changes, there were no structural changes in treated groups when compared to control. Conclusion: The leaves of ethanolic extract of M. jalapa is safe when administered for 28 days. There were no deaths or signs of toxicity in treated rats during acute toxicity studies and subacute toxicity studies

Daisy Chella et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: 2321-5674(Print) ISSN: 2320 – 3471(Online) Formulation and characterization of Methotrexate loaded sodium alginate chitosan

The aim of the present work was to formulate nanoparticles for Methotrexate drug. Methotrexate is an anticancer, disease modifying anti rheumatic drug, and BCS Class – III drug having high solubility and low permeability. Nanoparticles were prepared by ionotropic pregelation method using Box Behnen Formula. The concentration of chitosan (X1),concentration of sodium alginate (X2) and concentration of Methotrexate (X3) were chosen as independent variables while particle size, drug entrapment efficiency and percentage drug release at 36 th hour, was taken as dependent variables. The dissolution profile of selected formulations was fitted to zero order, first order, Higuchi and Korsemayer Peppas models to ascertain the kinetic modeling of drug release. The prepared formulations were further evaluated for characterization like surface morphology, particle size distribution, zetapotential and drug excipient interaction study by Fourier Transformer Infra Red Spectroscopy, Differential Scanning Calorimetry and X-ray Diffraction. All independent variables were found to significantly influence the particle size, entrapment efficiency and percentage of drug release. The in- vitro drug release profile showed that the suitability of sodium alginate-chitosan loaded nanoparticles in controlled release of methotrexate for prolonged time

Physio-morphological and Mechanical propertiesof chillies for Mechanical Harvesting

The plants and its produce characteristics are the basis to design a crop specific harvester. The objective of this study was to determine the physical, morphological and mechanical properties of chilli crop and fruits, that can be used in the design of harvester machine. The observations and data were collected by taking measurements at harvesting stage of three chilli cultivars. The fruit bearing behavior of plants was solitary with fruit position erect in Demon F1 and pendent in Araka Meghana and Mahyco Tejaswini. The plant height ranged between 81.76 to 84.87cm depending on cultivars and fruits per plant were170.25 number for Tejaswini, 158.96 and 156.15 number, respectively for Araka Meghana and Demon F1. It was observed that the length and diameter at shoulder of fruits was in the range of 4.97 to 10.44 cm and 0.8 to 1,25 cm, respectively. The moisture content reduced in leaves, stems and fruits as the maturation changed from matured green fruits bearing of plants to semi dry condition. The detachment force of fruits from plants increased as the fruits colour changed from matured green to fully ripened red and there after decreased

Physio-morphological and Mechanical propertiesof chillies for Mechanical Harvesting

The plants and its produce characteristics are the basis to design a crop specific harvester. The objective of this study was to determine the physical, morphological and mechanical properties of chilli crop and fruits, that can be used in the design of harvester machine. The observations and data were collected by taking measurements at harvesting stage of three chilli cultivars. The fruit bearing behavior of plants was solitary with fruit position erect in Demon F1 and pendent in Araka Meghana and Mahyco Tejaswini. The plant height ranged between 81.76 to 84.87cm depending on cultivars and fruits per plant were170.25 number for Tejaswini, 158.96 and 156.15 number, respectively for Araka Meghana and Demon F1. It was observed that the length and diameter at shoulder of fruits was in the range of 4.97 to 10.44 cm and 0.8 to 1,25 cm, respectively. The moisture content reduced in leaves, stems and fruits as the maturation changed from matured green fruits bearing of plants to semi dry condition. The detachment force of fruits from plants increased as the fruits colour changed from matured green to fully ripened red and there after decreased

Bacterial diversity analysis of Yumthang hot spring, North Sikkim, India by Illumina sequencing

Abstract Background Hot springs harbor rich bacterial diversity that could be the source of commercially important enzymes, antibiotics and many more products. Most of the hot springs present in Northeast of India are unexplored and their microbial diversity analysis could be of great interest to facilitate various industrial, agricultural and medicinal applications. The present study is an attempt to analyze the comprehensive bacterial diversity of Yumthang hot spring, Sikkim located at an altitude of 11, 800 ft. with a close proximity of Tibet 27° 47′ 30″ N 88° 42′ E using culture independent approach i.e. 16S rRNA gene amplicon metagenomic sequencing. Results The temperature and pH of the hot spring was recorded as 390–410 C and 8 respectively. Metagenome comprised of 1, 381,343 raw sequences with a sequence length of 151 bp and 55.62% G + C content. Metagenome sequence information is submitted at NCBI, SRA database under accession no. SRP057072. A total of 9, 95, 955 pre-processed reads were clustered into 1, 999 representative OTUs (operational taxonomical units) phylogenetically comprising of 17 bacterial phyla including unknown phylum indicating 99 families. Hot spring bacterial community is dominated by Proteobacteria (54.33%), Actinobacteria (32.19%), Firmicutes (6.03%), Bacteroidetes (2.87%) and unclassified bacteria (2.91%) respectively out of the total reads. Conclusions Several bacterial and archaeal sequences remained taxonomically unclassified, indicating potentially novel microorganisms in this hot spring ecosystem. Metagenomics of this habitat will facilitate identification of microorganisms possessing industrially relevant traits